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公开(公告)号：US10418127B2
公开(公告)日：2019-09-17
申请号：US13851864
申请日：2013-03-27
发明人： Tomohiro Hakozaki , Wenzhu Zhao , Robert Lloyd Binder , Jun Xu
IPC分类号： C12N15/10 , G01N33/50 , G16B20/00 , G16B25/00 , C12Q1/6881 , C12Q1/6883
摘要： A method of formulating a skin-lightening composition by identifying actives with a data architecture and incorporating the actives into a skin care composition. The data architecture can be used to identify connections between perturbagens and genes associated with skin tone. A gene expression profile for a control human cell is compared to the gene expression profile a cell exposed to perturbagen to identify the genes which are differentially expressed. The differentially expressed genes are analyzed and arranged into an ordered list of identifiers, which along with other instances create a data architecture.
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公开(公告)号：US09920357B2
公开(公告)日：2018-03-20
申请号：US13911698
申请日：2013-06-06
发明人： Robert Scott Youngquist , Jun Xu , Robert Lloyd Binder , Ping Hu , Teresa Dicolandrea , Thomas Larry Dawson , Brian Wilson Howard
CPC分类号： C12Q1/6837 , G06F19/18 , G06F19/20
摘要： Provided are methods and systems for determining functional relationships between a cosmetic agent and a hair biology condition of interest. Also provided are methods and systems for identifying cosmetic agents that affect a hair biology condition, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both.
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公开(公告)号：US10563258B2
公开(公告)日：2020-02-18
申请号：US14749779
申请日：2015-06-25
发明人： Robert Lloyd Binder , Robert Scott Youngquist , Jun Xu , Kenton Duane Juhlin , Rosemarie Osborne , Scott Michael Hartman
IPC分类号： C12Q1/6883 , G16B20/00 , G16B25/00 , G16B50/00
摘要： A method for making a skin care composition by identifying connections between cosmetic agents and genes associated with one or more skin aging conditions. The method includes accessing a plurality of instances and at least one skin aging gene expression signature, comparing the at least one skin aging gene expression signature to the plurality of the instances, assigning a connectivity score to each instance based on the comparison and incorporating the cosmetic agent into a skin care composition when the connectivity score of the instance associated with the cosmetic agent has a negative correlation.
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公开(公告)号：US11633452B2
公开(公告)日：2023-04-25
申请号：US17080930
申请日：2020-10-27
IPC分类号： A61K38/08 , A61P15/02 , A61K9/107 , A61K31/198 , A61K31/355 , A61K38/06 , A61K47/44 , A61K9/16 , A61K31/047 , A61K31/407 , A61K36/22 , A61K36/48 , A61K36/49 , A61K36/54 , A61K36/899
摘要： A method of treating vaginal dryness by administering a vaginal care composition, which includes an effective amount of a vaginal care agent, to vaginal tissue of a user experiencing vaginal dryness. The vaginal care agent may be selected to specifically treat symptoms of vaginal dryness exhibited by the introitus and/or labia, based on the transcriptomic data of skin cells obtained therefrom. In some instances, the vaginal care composition may be applied to introitus and/or labia with a suitable implement configured for such use.
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公开(公告)号：US10468120B2
公开(公告)日：2019-11-05
申请号：US13851873
申请日：2013-03-27
发明人： Tomohiro Hakozaki , Wenzhu Zhao , Robert Lloyd Binder , Jun Xu
IPC分类号： G01N33/48 , G01N33/50 , G16B20/00 , C12Q1/6881 , C12N15/10 , C12Q1/6883 , G16B25/00
摘要： A method of generating a hyperpigmentation condition gene expression signature for use in identifying connections between perturbagens and genes associated with a skin pigmentation condition. The method includes providing a gene expression profile for a reference sample of human skin cells not affected with a pigmentation condition; generating a gene expression profile for a sample of human skin cells from a subject exhibiting the hyperpigmentation condition; comparing the expression profiles to determine a gene expression signature that includes a set of differentially expressed genes; assigning an identifier to each gene constituting the gene expression signature and ordering the identifiers according to the direction of differential expression to create one or more gene expression signature lists; and storing the one or more gene expression signature lists on at least one computer readable medium.
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公开(公告)号：US10282514B2
公开(公告)日：2019-05-07
申请号：US13851858
申请日：2013-03-27
发明人： Tomohiro Hakozaki , Wenzhu Zhao , Robert Lloyd Binder , Jun Xu
IPC分类号： G01N33/48 , G06F19/18 , C12Q1/6881 , C12N15/10 , G01N33/50 , C12Q1/6883 , G06F19/20
摘要： A method of constructing a data architecture for use in identifying connections between perturbagens and genes associated with skin tone. The method includes providing a gene expression profile for a control cell, generating a gene expression profile for a cell exposed to a perturbagen, identifying genes differentially expressed in response to the perturbagen, creating an ordered list of identifiers, storing the ordered list as an instance on a computer readable medium, and constructing a data architecture of stored instances.
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公开(公告)号：US10036741B2
公开(公告)日：2018-07-31
申请号：US13966418
申请日：2013-08-14
发明人： Kevin John Mills , Jun Xu , Robert Lloyd Binder , Robert Scott Youngquist , Deborah Ruth Finlay , Charles Carson Bascom
CPC分类号： G01N33/502 , C12Q1/6883 , C12Q2600/148 , C12Q2600/158 , G01N33/5008 , G06F16/245 , G16B25/00
摘要： Methods and systems for constructing a gene expression signature representative of a number of biological conditions, systems and methods for determining functional relationships between a skin-active agent and skin conditions of interest, and methods and systems for identifying skin-active agents with broad spectrum activity are provided.
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公开(公告)号：US09434993B2
公开(公告)日：2016-09-06
申请号：US14749717
申请日：2015-06-25
发明人： Robert Lloyd Binder , Robert Scott Youngquist , Jun Xu , Kenton Duane Juhlin , Rosemarie Osborne , Scott Michael Hartman
CPC分类号： C12Q1/6883 , C12Q2600/148 , C12Q2600/158 , G06F19/18 , G06F19/20 , G06F19/28
摘要： A system for identifying connections between a cosmetic agent and at least one gene associated with a skin aging condition. The system includes a computer readable medium having stored thereon a plurality of instances and a skin aging gene expression signature. Each instance comprises an ordered list of identifiers representing a plurality of differentially expressed genes generated as a result of contact between the cosmetic agent and a human fibroblast cell or a human keratinocyte cell. The computing device includes computer-readable instructions for accessing the plurality of instances and the skin aging gene expression signature stored on the computer readable medium, comparing each of the instances to the skin aging gene expression signature, and assigning a connectivity score to each of the instances based on the comparison.
摘要翻译： 一种用于鉴定美容剂与至少一种与皮肤老化状况相关的基因之间的连接的系统。 该系统包括其上存储有多个实例和皮肤老化基因表达特征的计算机可读介质。 每个实例包括代表由化妆剂与人成纤维细胞或人角质形成细胞之间接触而产生的多个差异表达基因的标识符的有序列表。 计算设备包括用于访问存储在计算机可读介质上的多个实例和皮肤老化基因表达签名的计算机可读指令，将每个实例与皮肤老化基因表达签名进行比较，并将连接性分数分配给每个 基于比较的实例。
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公开(公告)号：US20150292017A1
公开(公告)日：2015-10-15
申请号：US14749717
申请日：2015-06-25
发明人： Robert Lloyd Binder , Robert Scott Youngquist , Jun XU , Kenton Duane JUHLIN , Rosemarie OSBORNE , Scott Michael HARTMAN
CPC分类号： C12Q1/6883 , C12Q2600/148 , C12Q2600/158 , G06F19/18 , G06F19/20 , G06F19/28
摘要： A system for identifying connections between a cosmetic agent and at least one gene associated with a skin aging condition. The system includes a computer readable medium having stored thereon a plurality of instances and a skin aging gene expression signature. Each instance comprises an ordered list of identifiers representing a plurality of differentially expressed genes generated as a result of contact between the cosmetic agent and a human fibroblast cell or a human keratinocyte cell. The computing device includes computer-readable instructions for accessing the plurality of instances and the skin aging gene expression signature stored on the computer readable medium, comparing each of the instances to the skin aging gene expression signature, and assigning a connectivity score to each of the instances based on the comparison.
摘要翻译： 一种用于鉴定美容剂与至少一种与皮肤老化状况相关的基因之间的连接的系统。 该系统包括其上存储有多个实例和皮肤老化基因表达特征的计算机可读介质。 每个实例包括代表由化妆剂与人成纤维细胞或人角质形成细胞之间接触而产生的多个差异表达基因的标识符的有序列表。 计算设备包括用于访问存储在计算机可读介质上的多个实例和皮肤老化基因表达签名的计算机可读指令，将每个实例与皮肤老化基因表达签名进行比较，并将连接性分数分配给每个 基于比较的实例。
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10.发明申请SYSTEMS AND METHODS FOR IDENTIFYING COSMETIC AGENTS FOR HAIR/SCALP CARE COMPOSITIONS 有权用于鉴定头发/护肤组合物的化妆品的系统和方法公开(公告)号：US20130331342A1
公开(公告)日：2013-12-12
申请号：US13911698
申请日：2013-06-06
发明人： Robert Scott Youngquist , Jun Xu , Robert Lloyd Binder , Ping Hu , Teresa Dicolandrea , Thomas Larry Dawson , Brian Wilson Howard
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , G06F19/18 , G06F19/20
摘要： Provided are methods and systems for determining functional relationships between a cosmetic agent and a hair biology condition of interest. Also provided are methods and systems for identifying cosmetic agents that affect a hair biology condition, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both.
摘要翻译： 提供了用于确定化妆品和感兴趣的毛发生物学条件之间的功能关系的方法和系统。 还提供了用于鉴定影响毛发生物学条件的化妆品的方法和系统，以及通过这些方法和系统鉴定的用于制备化妆品组合物，个人护理产品或两者的试剂的使用。
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