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    Systems for identifying cosmetic agents for skin care compositions
    1.
    发明授权
    Systems for identifying cosmetic agents for skin care compositions 有权
    用于鉴定护肤组合物的化妆品的系统

    公开(公告)号：US09434993B2

    公开(公告)日：2016-09-06

    申请号：US14749717

    申请日：2015-06-25

    申请人： The Procter & Gamble Company

    发明人： Robert Lloyd Binder ,  Robert Scott Youngquist ,  Jun Xu ,  Kenton Duane Juhlin ,  Rosemarie Osborne ,  Scott Michael Hartman

    IPC分类号： C40B60/12 ,  C12Q1/68 ,  G06F19/18 ,  G06F19/20 ,  G06F19/28

    CPC分类号： C12Q1/6883 ,  C12Q2600/148 ,  C12Q2600/158 ,  G06F19/18 ,  G06F19/20 ,  G06F19/28

    摘要： A system for identifying connections between a cosmetic agent and at least one gene associated with a skin aging condition. The system includes a computer readable medium having stored thereon a plurality of instances and a skin aging gene expression signature. Each instance comprises an ordered list of identifiers representing a plurality of differentially expressed genes generated as a result of contact between the cosmetic agent and a human fibroblast cell or a human keratinocyte cell. The computing device includes computer-readable instructions for accessing the plurality of instances and the skin aging gene expression signature stored on the computer readable medium, comparing each of the instances to the skin aging gene expression signature, and assigning a connectivity score to each of the instances based on the comparison.

    摘要翻译： 一种用于鉴定美容剂与至少一种与皮肤老化状况相关的基因之间的连接的系统。 该系统包括其上存储有多个实例和皮肤老化基因表达特征的计算机可读介质。 每个实例包括代表由化妆剂与人成纤维细胞或人角质形成细胞之间接触而产生的多个差异表达基因的标识符的有序列表。 计算设备包括用于访问存储在计算机可读介质上的多个实例和皮肤老化基因表达签名的计算机可读指令，将每个实例与皮肤老化基因表达签名进行比较，并将连接性分数分配给每个 基于比较的实例。