公开(公告)号：US09856283B2

公开(公告)日：2018-01-02

申请号：US14847439

申请日：2015-09-08

申请人： The Regents of The University of California ,  University College Dublin

发明人： Stefan Oscarson ,  John Vincent Fahy ,  Shaopeng Yuan ,  Stephen Carrington

IPC分类号： C07H15/04 ,  C07H5/04 ,  A61K31/7028 ,  A61K31/70 ,  A61K31/7016 ,  A61K31/702 ,  C07D309/10 ,  C07H13/04

CPC分类号： C07H15/04 ,  A61K31/70 ,  A61K31/7016 ,  A61K31/702 ,  A61K31/7028 ,  C07D309/10 ,  C07H5/04 ,  C07H13/04

摘要： There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a thiosaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.

公开(公告)号：US11021506B2

公开(公告)日：2021-06-01

申请号：US16692300

申请日：2019-11-22

申请人： The Regents of the University of California ,  University College Dublin

发明人： Stefan Oscarson ,  John Vincent Fahy ,  Shaopeng Yuan ,  Stephen Carrington

IPC分类号： C07H15/04 ,  C07H13/04 ,  A61K31/7028 ,  A61K31/70 ,  C07D309/10 ,  A61P11/12 ,  C07H5/04 ,  A61K31/7016 ,  A61K31/702 ,  A61P11/00 ,  A61P43/00 ,  A61P11/04 ,  A61P11/06

摘要： There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a thiosaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.

公开(公告)号：US10526359B2

公开(公告)日：2020-01-07

申请号：US15822616

申请日：2017-11-27

申请人： The Regents of The University of California ,  University College Dublin

发明人： Stefan Oscarson ,  John Vincent Fahy ,  Shaopeng Yuan ,  Stephen Carrington

IPC分类号： C07H15/04 ,  A61K31/7028 ,  A61K31/70 ,  A61K31/7016 ,  A61K31/702 ,  C07D309/10 ,  C07H13/04 ,  C07H5/04

摘要： There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a thiosaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.

公开(公告)号：US20160060284A1

公开(公告)日：2016-03-03

申请号：US14847439

申请日：2015-09-08

申请人： The Regents of The University of California ,  University College Dublin

发明人： Stefan Oscarson ,  John Vincent Fahy ,  Shaopeng Yuan ,  Stephen Carrington

IPC分类号： C07H15/04 ,  C07H5/04

CPC分类号： C07H15/04 ,  A61K31/70 ,  A61K31/7016 ,  A61K31/702 ,  A61K31/7028 ,  C07D309/10 ,  C07H5/04 ,  C07H13/04

摘要： There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a thiosaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.

摘要翻译： 特别提供了在有需要的受试者中降低粘液弹性或降低粘液粘度的方法，所述方法包括向受试者施用有效量的硫糖粘液溶解剂，以及可用于该方法的化合物和药物组合物。

公开(公告)号：US20180111955A1

公开(公告)日：2018-04-26

申请号：US15822616

申请日：2017-11-27

申请人： The Regents of The University of California ,  National University of Dublin

发明人： Stefan Oscarson ,  John Vincent Fahy ,  Shaopeng Yuan ,  Stephen Carrington

IPC分类号： C07H15/04 ,  C07H5/04 ,  A61K31/7028 ,  A61K31/70 ,  A61K31/7016 ,  A61K31/702 ,  C07D309/10 ,  C07H13/04

摘要： There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a thiosaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.