公开(公告)号：US20250137036A1

公开(公告)日：2025-05-01

申请号：US18936581

申请日：2024-11-04

Applicant: The Regents of the University of California

Inventor： Drew Hall ,  Chung-Lun Hsu ,  Alexander Sun ,  Yunting Zhao ,  Eliah Aronoff-Spencer

IPC: C12Q1/6825 ,  G01N27/02

Abstract: Disclosed are biosensor devices, systems, and methods for point-of-care applications. In some aspects, a biosensor system includes a biosensor chip device to measure impedance at an electrode-electrolyte interface, which includes an electrochemical sensor comprising a first electrode including a functionalization layer exposing a molecular binding site to bind a target molecule for detection and a second electrode that does not include the binding site, and an electronic circuit unit corresponding to each electrode of the electrochemical sensor including a transimpedance amplifier, a phase detector to determine a relative phase shift in the detected electrical signal caused by an impedance change from a binding event of the target molecule at the molecular binding site, and a time-to-digital converter to quantize and average phase data points in time to remove uncorrelated noise from the detected electrical signal; and a signal generator to produce an electrical excitation signal applied across the electrode-electrolyte interface.

公开(公告)号：US12157914B2

公开(公告)日：2024-12-03

申请号：US16976464

申请日：2019-02-28

Applicant: The Regents of the University of California

Inventor： Drew Hall ,  Chung-Lun Hsu ,  Alexander Sun ,  Yunting Zhao ,  Eliah Aronoff-Spencer

IPC: C12Q1/6825 ,  G01N27/02

Abstract: Disclosed are biosensor devices, systems, and methods for point-of-care applications. In some aspects, a biosensor system includes a biosensor chip device to measure impedance at an electrode-electrolyte interface, which includes an electrochemical sensor comprising a first electrode including a functionalization layer exposing a molecular binding site to bind a target molecule for detection and a second electrode that does not include the binding site, and an electronic circuit unit corresponding to each electrode of the electrochemical sensor including a transimpedance amplifier, a phase detector to determine a relative phase shift in the detected electrical signal caused by an impedance change from a binding event of the target molecule at the molecular binding site, and a time-to-digital converter to quantize and average phase data points in time to remove uncorrelated noise from the detected electrical signal; and a signal generator to produce an electrical excitation signal applied across the electrode-electrolyte interface.

公开(公告)号：US20210087614A1

公开(公告)日：2021-03-25

申请号：US16976464

申请日：2019-02-28

Applicant: The Regents of the University of California

Inventor： Drew Hall ,  Chung-Lun Hsu ,  Alexander Sun ,  Yunting Zhao ,  Eliah Aronoff-Spencer

IPC: C12Q1/6825 ,  G01N27/02

Abstract: Disclosed are biosensor devices, systems, and methods for point-of-care applications. In some aspects, a biosensor system includes a biosensor chip device to measure impedance at an electrode-electrolyte interface, which includes an electrochemical sensor comprising a first electrode including a functionalization layer exposing a molecular binding site to bind a target molecule for detection and a second electrode that does not include the binding site, and an electronic circuit unit corresponding to each electrode of the electrochemical sensor including a transimpedance amplifier, a phase detector to determine a relative phase shift in the detected electrical signal caused by an impedance change from a binding event of the target molecule at the molecular binding site, and a time-to-digital converter to quantize and average phase data points in time to remove uncorrelated noise from the detected electrical signal; and a signal generator to produce an electrical excitation signal applied across the electrode-electrolyte interface.