公开(公告)号：US20250137036A1

公开(公告)日：2025-05-01

申请号：US18936581

申请日：2024-11-04

Applicant: The Regents of the University of California

Inventor： Drew Hall ,  Chung-Lun Hsu ,  Alexander Sun ,  Yunting Zhao ,  Eliah Aronoff-Spencer

IPC: C12Q1/6825 ,  G01N27/02

Abstract: Disclosed are biosensor devices, systems, and methods for point-of-care applications. In some aspects, a biosensor system includes a biosensor chip device to measure impedance at an electrode-electrolyte interface, which includes an electrochemical sensor comprising a first electrode including a functionalization layer exposing a molecular binding site to bind a target molecule for detection and a second electrode that does not include the binding site, and an electronic circuit unit corresponding to each electrode of the electrochemical sensor including a transimpedance amplifier, a phase detector to determine a relative phase shift in the detected electrical signal caused by an impedance change from a binding event of the target molecule at the molecular binding site, and a time-to-digital converter to quantize and average phase data points in time to remove uncorrelated noise from the detected electrical signal; and a signal generator to produce an electrical excitation signal applied across the electrode-electrolyte interface.

公开(公告)号：US20210087614A1

公开(公告)日：2021-03-25

申请号：US16976464

申请日：2019-02-28

Applicant: The Regents of the University of California

Inventor： Drew Hall ,  Chung-Lun Hsu ,  Alexander Sun ,  Yunting Zhao ,  Eliah Aronoff-Spencer

IPC: C12Q1/6825 ,  G01N27/02

Abstract: Disclosed are biosensor devices, systems, and methods for point-of-care applications. In some aspects, a biosensor system includes a biosensor chip device to measure impedance at an electrode-electrolyte interface, which includes an electrochemical sensor comprising a first electrode including a functionalization layer exposing a molecular binding site to bind a target molecule for detection and a second electrode that does not include the binding site, and an electronic circuit unit corresponding to each electrode of the electrochemical sensor including a transimpedance amplifier, a phase detector to determine a relative phase shift in the detected electrical signal caused by an impedance change from a binding event of the target molecule at the molecular binding site, and a time-to-digital converter to quantize and average phase data points in time to remove uncorrelated noise from the detected electrical signal; and a signal generator to produce an electrical excitation signal applied across the electrode-electrolyte interface.

公开(公告)号：US12157914B2

公开(公告)日：2024-12-03

申请号：US16976464

申请日：2019-02-28

Applicant: The Regents of the University of California

Inventor： Drew Hall ,  Chung-Lun Hsu ,  Alexander Sun ,  Yunting Zhao ,  Eliah Aronoff-Spencer

IPC: C12Q1/6825 ,  G01N27/02

Abstract: Disclosed are biosensor devices, systems, and methods for point-of-care applications. In some aspects, a biosensor system includes a biosensor chip device to measure impedance at an electrode-electrolyte interface, which includes an electrochemical sensor comprising a first electrode including a functionalization layer exposing a molecular binding site to bind a target molecule for detection and a second electrode that does not include the binding site, and an electronic circuit unit corresponding to each electrode of the electrochemical sensor including a transimpedance amplifier, a phase detector to determine a relative phase shift in the detected electrical signal caused by an impedance change from a binding event of the target molecule at the molecular binding site, and a time-to-digital converter to quantize and average phase data points in time to remove uncorrelated noise from the detected electrical signal; and a signal generator to produce an electrical excitation signal applied across the electrode-electrolyte interface.

公开(公告)号：US20180253588A1

公开(公告)日：2018-09-06

申请号：US15913806

申请日：2018-03-06

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Eliah Aronoff-Spencer ,  Isaiah Freerksen ,  Staal Vinterbo ,  Yunting Zhao ,  Tomer Kalisky

IPC: G06K9/00

CPC classification number: G06K9/00087 ,  G06K9/00013 ,  G06K9/00046 ,  G06K9/00919 ,  H01L27/14678

Abstract: An adjustable fingerprint capturing device is configured to stabilize a finger of a subject. The adjustable fingerprint capturing device comprises an imaging device(s) configured to capture an image(s) of the finger. The adjustable fingerprint capturing device comprises a detection sensor(s) configured to detect presence of the finger. The adjustable fingerprint capturing device comprises a controller configured to activate the imaging device(s) based on input from the detection sensor(s). The adjustable fingerprint capturing device comprises a housing disposed to: the imaging device(s), the detection sensor(s), and the controller. The adjustable fingerprint capturing device comprises a finger stabilizer comprising at least one cantilever. The adjustable fingerprint capturing device comprises at least one cantilever spring connecting the housing and the at least one cantilever. The at least one cantilever spring is configured to create a space between the housing and the finger stabilizer. The space is large enough to accept the finger.