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    ELECTROCHEMICAL BIOSENSOR ARRAY DEVICES, SYSTEMS, AND METHODS FOR POINT-OF-CARE DETECTION
    1.
    发明申请
    ELECTROCHEMICAL BIOSENSOR ARRAY DEVICES, SYSTEMS, AND METHODS FOR POINT-OF-CARE DETECTION 有权

    公开(公告)号：US20250137036A1

    公开(公告)日：2025-05-01

    申请号：US18936581

    申请日：2024-11-04

    Applicant: The Regents of the University of California

    Inventor： Drew Hall ,  Chung-Lun Hsu ,  Alexander Sun ,  Yunting Zhao ,  Eliah Aronoff-Spencer

    IPC: C12Q1/6825 ,  G01N27/02

    Abstract: Disclosed are biosensor devices, systems, and methods for point-of-care applications. In some aspects, a biosensor system includes a biosensor chip device to measure impedance at an electrode-electrolyte interface, which includes an electrochemical sensor comprising a first electrode including a functionalization layer exposing a molecular binding site to bind a target molecule for detection and a second electrode that does not include the binding site, and an electronic circuit unit corresponding to each electrode of the electrochemical sensor including a transimpedance amplifier, a phase detector to determine a relative phase shift in the detected electrical signal caused by an impedance change from a binding event of the target molecule at the molecular binding site, and a time-to-digital converter to quantize and average phase data points in time to remove uncorrelated noise from the detected electrical signal; and a signal generator to produce an electrical excitation signal applied across the electrode-electrolyte interface.

    Implantable biosensor
    2.
    发明授权
    Implantable biosensor 有权

    公开(公告)号：US12004855B2

    公开(公告)日：2024-06-11

    申请号：US16620337

    申请日：2018-06-07

    Applicant: The Regents of the University of California

    Inventor： Drew Hall ,  Saurabh Kulkarni

    IPC: A61B5/145 ,  A61B5/00 ,  A61B5/05 ,  A61B5/1486

    CPC classification number: A61B5/14532 ,  A61B5/0031 ,  A61B5/05 ,  A61B5/145 ,  A61B5/14539 ,  A61B5/14865

    Abstract: An implantable biosensor may be placed subcutaneously to monitor the concentration of an analyte in a body fluid. The biosensor may include an electrochemical cell and an antenna. The components of the biosensor, including the electrochemical cell and the antenna, may be disposed on a same substrate. The electrochemical cell may include multiple electrodes for performing electrochemical measurements that include a first measurement of the analyte concentration in the body fluid, a second measurement of a background interference present in the body fluid, and a third measurement of a pH level within the body fluid. The antenna may receive, from a transceiver, radio frequency (RF) waves for wirelessly powering the implantable biosensor. The antenna may further transmit, back to the transceiver, a backscatter signal encoding a result of the electrochemical measurements.

    ELECTROCHEMICAL BIOSENSOR ARRAY DEVICES, SYSTEMS, AND METHODS FOR POINT-OF-CARE DETECTION
    4.
    发明申请
    ELECTROCHEMICAL BIOSENSOR ARRAY DEVICES, SYSTEMS, AND METHODS FOR POINT-OF-CARE DETECTION 有权

    公开(公告)号：US20210087614A1

    公开(公告)日：2021-03-25

    申请号：US16976464

    申请日：2019-02-28

    Applicant: The Regents of the University of California

    Inventor： Drew Hall ,  Chung-Lun Hsu ,  Alexander Sun ,  Yunting Zhao ,  Eliah Aronoff-Spencer

    IPC: C12Q1/6825 ,  G01N27/02

    Abstract: Disclosed are biosensor devices, systems, and methods for point-of-care applications. In some aspects, a biosensor system includes a biosensor chip device to measure impedance at an electrode-electrolyte interface, which includes an electrochemical sensor comprising a first electrode including a functionalization layer exposing a molecular binding site to bind a target molecule for detection and a second electrode that does not include the binding site, and an electronic circuit unit corresponding to each electrode of the electrochemical sensor including a transimpedance amplifier, a phase detector to determine a relative phase shift in the detected electrical signal caused by an impedance change from a binding event of the target molecule at the molecular binding site, and a time-to-digital converter to quantize and average phase data points in time to remove uncorrelated noise from the detected electrical signal; and a signal generator to produce an electrical excitation signal applied across the electrode-electrolyte interface.

    Electrochemical biosensor array devices, systems, and methods for point-of-care detection
    5.
    发明授权
    Electrochemical biosensor array devices, systems, and methods for point-of-care detection 有权

    公开(公告)号：US12157914B2

    公开(公告)日：2024-12-03

    申请号：US16976464

    申请日：2019-02-28

    Applicant: The Regents of the University of California

    Inventor： Drew Hall ,  Chung-Lun Hsu ,  Alexander Sun ,  Yunting Zhao ,  Eliah Aronoff-Spencer

    IPC: C12Q1/6825 ,  G01N27/02

    Abstract: Disclosed are biosensor devices, systems, and methods for point-of-care applications. In some aspects, a biosensor system includes a biosensor chip device to measure impedance at an electrode-electrolyte interface, which includes an electrochemical sensor comprising a first electrode including a functionalization layer exposing a molecular binding site to bind a target molecule for detection and a second electrode that does not include the binding site, and an electronic circuit unit corresponding to each electrode of the electrochemical sensor including a transimpedance amplifier, a phase detector to determine a relative phase shift in the detected electrical signal caused by an impedance change from a binding event of the target molecule at the molecular binding site, and a time-to-digital converter to quantize and average phase data points in time to remove uncorrelated noise from the detected electrical signal; and a signal generator to produce an electrical excitation signal applied across the electrode-electrolyte interface.

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