公开(公告)号：US20240409571A1

公开(公告)日：2024-12-12

申请号：US18627308

申请日：2024-04-04

Applicant: The Regents of the University of California

Inventor： Xi CHEN ,  Hai YU ,  Bijoyananda MISHRA ,  Zimin ZHENG ,  Anand Kumar AGRAHARI ,  Arin GUCCHAIT

IPC: C07H15/12 ,  C07H1/00 ,  C12P13/00

Abstract: Described herein are novel stable 9-N-, 8-N-, and 7-N-acetyl analogues of instable 9-O-acetyl, 8-O-acetyl, and 7-O-acetyl b-series gangliosides and glycosphingosines, including GD3, GD2, GD1b, GT1b, GQ1b, and their glycosphingosines. Chemoenzymatic methods for the production of the stable 9-N-, 8-N-, and 7-N-acetyl analogues are also described herein.