公开(公告)号：US20180051320A1

公开(公告)日：2018-02-22

申请号：US15348855

申请日：2016-11-10

Applicant: The Regents of the University of California

Inventor： Joseph L. DeRisi ,  Wei Gu ,  Emily D. Crawford ,  Brian O'Donovan ,  Michael Wilson ,  Eric D. Chow ,  Hanna Retallack

IPC: C12Q1/68

CPC classification number: C12Q1/6806 ,  C12Q1/6848 ,  C12Q1/6874 ,  C12Q2521/301

Abstract: Among other things, this disclosure describes a method comprising: cleaving a plurality of target sequences in an adaptor-tagged sequencing library using population of reprogrammed nucleic acid-directed endonucleases; non-specifically amplifying the library, thereby amplifying fragments that have not been cleaved; and sequencing the amplified sample.

公开(公告)号：US20220196662A1

公开(公告)日：2022-06-23

申请号：US17439359

申请日：2020-03-13

Applicant: Chan Zuckerberg Biohub, Inc. ,  The Regents of the University of California ,  Mayo Foundation for Medical Education and Research

Inventor： Joseph L. DeRisi ,  Michael R. Wilson ,  Caleigh Mandel-Brehm ,  Brian O'Donovan ,  Sean J. Pittock ,  Divyanshu Dubey ,  Thomas J. Kryzer ,  Vanda A. Lennon ,  Andrew McKeon

IPC: G01N33/574 ,  G01N33/564 ,  A61K39/395 ,  A61K38/45 ,  A61P35/00

Abstract: This disclosure describes methods and compositions for detecting the presence of a Kelch-like protein 11 autoantibody in a biological sample. Also provided are methods of treating subjects with testicular cancer or a premalignant condition and paraneoplastic encephalomyelitis.