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公开(公告)号：US20240304283A1
公开(公告)日：2024-09-12
申请号：US18390753
申请日：2023-12-20
发明人： Stephanie I. Fraley , Sinead Charpentier , Daniel Ortiz Velez , Mridu Sinha , Benjamin Albert Yang
摘要： Methods are provided for nucleic acid analysis via a platform which incorporates a digital sample partitioning platform such as a microfluidic chip or digital droplet platform and instrumentation to accomplish universal amplification, High Resolution Melting (TIRM), and machine learning within reactions simultaneously.
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公开(公告)号：US20190293630A1
公开(公告)日：2019-09-26
申请号：US16465991
申请日：2017-12-01
申请人： Stephanie Fraley , Hannah Carter , Daniel Ortiz Velez , Brian Tsui , The Regents of the University of California
IPC分类号： G01N33/50 , C12Q1/6886 , C12N5/09
摘要： Disclosed herein is a novel gene signature of metastatic cancer cells and a novel three-dimensional (3D) culture system for use in improved methods of predicting metastasis or prognosis in cancer. Accordingly, described herein are methods of determining a risk of metastasis, methods of predicting prognosis for cancer patients, methods of treating a cancer patient identified at high risk of metastasis, methods of treating a cancer patient identified as having poorer prognosis, methods for determining the migration capacity of a tumor, methods of screening a tumor for sensitivity to a drug, and kits for use in performing these methods.
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公开(公告)号：US20210241857A1
公开(公告)日：2021-08-05
申请号：US16472734
申请日：2017-12-22
发明人： Stephanie I Fraley , Sinead Charpentier , Daniel Ortiz Velez , Mridu Sinha , Benjamin Albert Yang
摘要： Methods are provided for nucleic acid analysis via a platform which incorporates a digital sample partitioning platform such as a microfluidic chip or digital droplet platform and instrumentation to accomplish universal amplification, High Resolution Melting (HRM), and machine learning within reactions simultaneously.
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公开(公告)号：US11915795B2
公开(公告)日：2024-02-27
申请号：US16472734
申请日：2017-12-22
发明人： Stephanie I. Fraley , Sinead Charpentier , Daniel Ortiz Velez , Mridu Sinha , Benjamin Albert Yang
摘要： Methods are provided for nucleic acid analysis via a platform which incorporates a digital sample partitioning platform such as a microfluidic chip or digital droplet platform and instrumentation to accomplish universal amplification, High Resolution Melting (HRM), and machine learning within reactions simultaneously.
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公开(公告)号：US20230375527A1
公开(公告)日：2023-11-23
申请号：US18110341
申请日：2023-02-15
IPC分类号： G01N33/50 , C12N5/09 , C12Q1/6886 , G01N33/574
CPC分类号： G01N33/5011 , C12N5/0693 , C12Q1/6886 , G01N33/5023 , G01N33/57484 , C12N2533/54 , C12N2533/90 , C12Q2600/118 , C12Q2600/158 , G01N2800/52
摘要： Disclosed herein is a novel gene signature of metastatic cancer cells and a novel three-dimensional (3D) culture system for use in improved methods of predicting metastasis or prognosis in cancer. Accordingly, described herein are methods of determining a risk of metastasis, methods of predicting prognosis for cancer patients, methods of treating a cancer patient identified at high risk of metastasis, methods of treating a cancer patient identified as having poorer prognosis, methods for determining the migration capacity of a tumor, methods of screening a tumor for sensitivity to a drug, and kits for use in performing these methods.
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