-
公开(公告)号：US20210077397A1
公开(公告)日：2021-03-18
申请号：US16948498
申请日：2020-09-21
发明人： Andre E. Nel , Jeffrey I. Zink , Huan Meng
IPC分类号： A61K9/127 , A61K31/7068 , A61K31/337 , A61K9/51 , A61K31/4709 , A61K31/713 , A61K31/7105 , A61K45/06 , A61K47/02
摘要： A submicron structure comprising a silica body defining a plurality of pores that are suitable to receive molecules therein, and having a surface, and a phospholipid bilayer coating the surface, wherein said submicron structure has a maximum dimension of less than one micron, and wherein the phospholipid bilayer stably seals the plurality of pores; and wherein the submicron structure is a member of a monodisperse population of submicron structures.
-
2.发明公开公开(公告)号：US20240285531A1
公开(公告)日：2024-08-29
申请号：US18429272
申请日：2024-01-31
发明人： Andre E. Nel , Jeffrey I. Zink , Huan Meng
IPC分类号： A61K9/127 , A61K9/51 , A61K31/337 , A61K31/4709 , A61K31/7068 , A61K31/7105 , A61K31/713 , A61K45/06 , A61K47/02
CPC分类号： A61K9/127 , A61K9/5115 , A61K31/337 , A61K31/4709 , A61K31/7068 , A61K31/7105 , A61K31/713 , A61K45/06 , A61K47/02
摘要： A submicron structure comprising a silica body defining a plurality of pores that are suitable to receive molecules therein, and having a surface, and a phospholipid bilayer coating the surface, wherein said submicron structure has a maximum dimension of less than one micron, and wherein the phospholipid bilayer stably seals the plurality of pores; and wherein the submicron structure is a member of a monodisperse population of submicron structures.
-
公开(公告)号：US20220160644A1
公开(公告)日：2022-05-26
申请号：US17384214
申请日：2021-07-23
发明人： Andre E. Nel , Huan Meng , Xiangsheng Liu
摘要： A nanocarrier including a silica body having a surface and defining a plurality of pores that are suitable to receive molecules therein is described. The nanocarrier also includes a lipid bilayer coating the surface, and a cargo-trapping agent within the phospholipid bilayer. The phospholipid bilayer stably seals the plurality of pores. The cargo-trapping reagent can be selected to interact with a desired cargo, such as a drug.
-
公开(公告)号：US10343903B2
公开(公告)日：2019-07-09
申请号：US15698486
申请日：2017-09-07
发明人： Jeffrey I. Zink , Andre E. Nel , Tian Xia , Zhaoxia Ji , Huan Meng , Zongxi Li , Monty Liong , Min Xue , Derrick Y. Tarn , Sanaz Gardner
IPC分类号： A61K9/14 , B82Y5/00 , A61K9/00 , A61K9/51 , A61K31/704 , A61K31/713
摘要： A submicron structure having a silica body defining a plurality of pores is described. The submicron body may be spherical or non-spherical, and may include a cationic polymer or co-polymer on the surface of said silica body. The submicron structure may further include an oligonucleotide and be used to deliver the oligonucleotide to a cell. The submicron structure may further include a therapeutic agent and be used to deliver the therapeutic agent to a cell. An oligonucleotide and therapeutic agent may be used together. For example, when the oligonucleotide is an siRNA, the composition may be used to decrease cellular resistance to the therapeutic agent by decreasing translation of a resistance gene.
-
公开(公告)号：US20190160015A1
公开(公告)日：2019-05-30
申请号：US16164030
申请日：2018-10-18
发明人： Andre E. Nel , Huan Meng , Xiangsheng Liu
IPC分类号： A61K9/51 , A61K45/06 , A61K31/4745 , A61K9/127 , A61K9/00
摘要： A nanocarrier including a silica body having a surface and defining a plurality of pores that are suitable to receive molecules therein is described. The nanocarrier also includes a lipid bilayer coating the surface, and a cargo-trapping agent within the phospholipid bilayer. The phospholipid bilayer stably seals the plurality of pores. The cargo-trapping reagent can be selected to interact with a desired cargo, such as a drug.
-
公开(公告)号：US20230338363A1
公开(公告)日：2023-10-26
申请号：US18019459
申请日：2021-08-02
发明人： Andre E. Nel , Huan Meng , Xiangsheng Liu
IPC分类号： A61K31/4745 , C07K16/28 , A61K31/4706 , A61K33/244 , A61K45/06 , A61P35/00
CPC分类号： A61K31/4745 , A61K31/4706 , A61K33/244 , A61K45/06 , A61P35/00 , C07K16/2818 , C07K16/2827 , A61K9/0019
摘要： In various embodiments, methods of treating a cancer are provided. In certain embodiments, the methods comprise administering to a mammal in need thereof i) one or more checkpoint inhibitor(s); and ii) one or more camptothecin analogs, and, optionally, or one or more autophagy inhibitors wherein said camptothecin analog, and one or more autophagy inhibitors, when present, are provided inside a delivery vehicle where said delivery vehicle comprises: a nanoparticle comprising one or more cavities disposed within said nanoparticle and an outside surface where said one or more cavities are in fluid communication the outside surface of said nanoparticle; said one or more camptothecin analog, one or more autophagy inhibitors, when present, are disposed within said one or more cavities; and a lipid bilayer is disposed on the surface of said nanoparticle where said lipid bilayer fully encapsulates the nanoparticle.
-
公开(公告)号：US11096900B2
公开(公告)日：2021-08-24
申请号：US16947539
申请日：2020-08-05
发明人： Andre E. Nel , Huan Meng , Xiangsheng Liu
摘要： A nanocarrier including a silica body having a surface and defining a plurality of pores that are suitable to receive molecules therein is described. The nanocarrier also includes a lipid bilayer coating the surface, and a cargo-trapping agent within the phospholipid bilayer. The phospholipid bilayer stably seals the plurality of pores. The cargo-trapping reagent can be selected to interact with a desired cargo, such as a drug.
-
公开(公告)号：US10765636B2
公开(公告)日：2020-09-08
申请号：US16164030
申请日：2018-10-18
发明人： Andre E. Nel , Huan Meng , Xiangsheng Liu
摘要： A nanocarrier including a silica body having a surface and defining a plurality of pores that are suitable to receive molecules therein is described. The nanocarrier also includes a lipid bilayer coating the surface, and a cargo-trapping agent within the phospholipid bilayer. The phospholipid bilayer stably seals the plurality of pores. The cargo-trapping reagent can be selected to interact with a desired cargo, such as a drug.
-
公开(公告)号：US20190382265A1
公开(公告)日：2019-12-19
申请号：US16427253
申请日：2019-05-30
发明人： Jeffrey I. Zink , Andre E. Nel , Tian Xia , Zhaoxia Ji , Huan Meng , Zongxi Li , Monty Liong , Min Xue , Derrick Y. Tarn , Sanaz Gardner
IPC分类号： B82Y5/00 , A61K9/00 , A61K9/51 , A61K31/704 , A61K31/713
摘要： A submicron structure having a silica body defining a plurality of pores is described. The submicron body may be spherical or non-spherical, and may include a cationic polymer or co-polymer on the surface of said silica body. The submicron structure may further include an oligonucleotide and be used to deliver the oligonucleotide to a cell. The submicron structure may further include a therapeutic agent and be used to deliver the therapeutic agent to a cell. An oligonucleotide and therapeutic agent may be used together. For example, when the oligonucleotide is an siRNA, the composition may be used to decrease cellular resistance to the therapeutic agent by decreasing translation of a resistance gene.
-
公开(公告)号：US10143660B2
公开(公告)日：2018-12-04
申请号：US15798287
申请日：2017-10-30
发明人： Andre E. Nel , Huan Meng , Xiangsheng Liu
IPC分类号： A61K9/51 , A61K9/127 , A61K9/00 , A61K31/4745 , A61K45/06
摘要： A nanocarrier including a silica body having a surface and defining a plurality of pores that are suitable to receive molecules therein is described. The nanocarrier also includes a lipid bilayer coating the surface, and a cargo-trapping agent within the phospholipid bilayer. The phospholipid bilayer stably seals the plurality of pores. The cargo-trapping reagent can be selected to interact with a desired cargo, such as a drug.
-
-
-
-
-
-
-
-
-
搜索结果
23 条记录 (耗时 0.035 秒)
