公开(公告)号：US20230172869A1

公开(公告)日：2023-06-08

申请号：US17919734

申请日：2021-04-19

申请人： The Regents of the University of California

发明人： Andre E. Nel ,  Huan Meng ,  Tian Xia ,  Qi Liu ,  Sean Allen

IPC分类号： A61K9/51 ,  A61K47/69 ,  A61K39/215 ,  A61K39/39 ,  C07K14/005 ,  A61P31/14

CPC分类号： A61K9/5153 ,  A61K47/6937 ,  A61K39/215 ,  A61K39/39 ,  C07K14/005 ,  A61P31/14 ,  A61K2039/572

摘要： In various embodiments immunogenic nanoparticles are provided that are capable of raising an immune response directed against one or more viral proteins and/or protein fragments. In certain embodiments the immunogenic nanoparticles raise an immune response directed against a virus (e.g., SARS-CoV-2 (2019-nCoV), SARS-CoV-2, and MERS-CoV, and the like). In certain embodiments the immunogenic nanoparticles comprise a nanoparticle formed from one or more biocompatible polymer(s), one or more viral proteins or fragments thereof encapsulated within or attached to the biocompatible polymer(s) where the viral protein or fragment thereof comprises an antigen to which an immune response is to be induced by administration of the immunogenic nanoparticle to a mammal and where the immunogenic nanoparticle further comprises an adjuvant (e.g., a STING agonist).

公开(公告)号：US20220395563A1

公开(公告)日：2022-12-15

申请号：US17775245

申请日：2020-11-11

申请人： The Regents of the University of California

发明人： Andre E. Nel ,  Tian Xia ,  Qi Liu

IPC分类号： A61K39/00 ,  A61K39/35 ,  A61K31/436 ,  A61P37/08 ,  A61P11/06

摘要： In various embodiments tolerogenic nanoparticles are provided that induce immune tolerance to one or more desired antigen(s) and/or that reduce an immune response to those antigen(s). In certain embodiments the tolerogenic nanoparticle comprises a nanoparticle comprising a biocompatible polymer; an antigen disposed within or attached to said biocompatible polymer where said antigen comprises an antigen to which immune tolerance is to be induced by administration of said tolerogenic nanoparticle to a mammal; and a first targeting moiety that binds to a scavenger receptor in the liver, and/or a second targeting moiety that binds to a mannose receptor in the liver, and/or a third targeting moiety that binds to hepatocytes, wherein said first and/or second and/or third targeting moiety are attached to the surface of said nanoparticle.

公开(公告)号：US10343903B2

公开(公告)日：2019-07-09

申请号：US15698486

申请日：2017-09-07

申请人： The Regents of the University of California

发明人： Jeffrey I. Zink ,  Andre E. Nel ,  Tian Xia ,  Zhaoxia Ji ,  Huan Meng ,  Zongxi Li ,  Monty Liong ,  Min Xue ,  Derrick Y. Tarn ,  Sanaz Gardner

IPC分类号： A61K9/14 ,  B82Y5/00 ,  A61K9/00 ,  A61K9/51 ,  A61K31/704 ,  A61K31/713

摘要： A submicron structure having a silica body defining a plurality of pores is described. The submicron body may be spherical or non-spherical, and may include a cationic polymer or co-polymer on the surface of said silica body. The submicron structure may further include an oligonucleotide and be used to deliver the oligonucleotide to a cell. The submicron structure may further include a therapeutic agent and be used to deliver the therapeutic agent to a cell. An oligonucleotide and therapeutic agent may be used together. For example, when the oligonucleotide is an siRNA, the composition may be used to decrease cellular resistance to the therapeutic agent by decreasing translation of a resistance gene.

公开(公告)号：US11981571B2

公开(公告)日：2024-05-14

申请号：US17531651

申请日：2021-11-19

申请人： The Regents of the University of California ,  Northwestern University

发明人： Andre E. Nel ,  Tian Xia ,  Ruibin Li ,  Mark C. Hersam ,  Nikhita D. Mansukhani ,  Linda Guiney

IPC分类号： C01B32/198 ,  A01N43/90 ,  A01N59/00 ,  A61L27/08

CPC分类号： C01B32/198 ,  A01N43/90 ,  A01N59/00 ,  A61L27/08

摘要： In various embodiments functionalized graphene oxide(s) are provided that demonstrate improved antimicrobial activity, where the graphene oxide(s) are functionalized to increase carbon radical (·C) density.

公开(公告)号：US20220153589A1

公开(公告)日：2022-05-19

申请号：US17531651

申请日：2021-11-19

申请人： The Regents of the University of California ,  Northwestern University

发明人： Andre E. Nel ,  Tian Xia ,  Ruibin Li ,  Mark C. Hersam ,  Nikhita D. Mansukhani ,  Linda Guiney

IPC分类号： C01B32/198 ,  A01N43/90 ,  A01N59/00 ,  A61L27/08

摘要： In various embodiments functionalized graphene oxide(s) are provided that demonstrate improved antimicrobial activity, where the graphene oxide(s) are functionalized to increase carbon radical (.C) density.

公开(公告)号：US11208330B2

公开(公告)日：2021-12-28

申请号：US16348862

申请日：2017-11-15

申请人： The Regents of the University of California ,  Northwestern University

发明人： Andre E. Nel ,  Tian Xia ,  Ruibin Li ,  Mark C. Hersam ,  Nikhita D. Mansukhani ,  Linda Guiney

IPC分类号： C01B32/198 ,  A01N43/90 ,  A01N59/00 ,  A61L27/08

摘要： In various embodiments functionalized graphene oxide(s) are provided that demonstrate improved antimicrobial activity, where the graphene oxide(s) are functionalized to increase carbon radical (.C) density.

公开(公告)号：US20200270134A1

公开(公告)日：2020-08-27

申请号：US16348862

申请日：2017-11-15

申请人： The Regents of the University of California ,  Northwestern University

发明人： Andre E. Nel ,  Tian Xia ,  Ruibin Li ,  Mark C. Hersam ,  Nikhita D. Mansukhani ,  Linda Guiney

IPC分类号： C01B32/198 ,  A01N43/90 ,  A61L27/08 ,  A01N59/00

摘要： In various embodiments functionalized graphene oxide(s) are provided that demonstrate improved antimicrobial activity, where the graphene oxide(s) are functionalized to increase carbon radical (.C) density.

公开(公告)号：US20190382265A1

公开(公告)日：2019-12-19

申请号：US16427253

申请日：2019-05-30

申请人： The Regents of the University of California

发明人： Jeffrey I. Zink ,  Andre E. Nel ,  Tian Xia ,  Zhaoxia Ji ,  Huan Meng ,  Zongxi Li ,  Monty Liong ,  Min Xue ,  Derrick Y. Tarn ,  Sanaz Gardner

IPC分类号： B82Y5/00 ,  A61K9/00 ,  A61K9/51 ,  A61K31/704 ,  A61K31/713

摘要： A submicron structure having a silica body defining a plurality of pores is described. The submicron body may be spherical or non-spherical, and may include a cationic polymer or co-polymer on the surface of said silica body. The submicron structure may further include an oligonucleotide and be used to deliver the oligonucleotide to a cell. The submicron structure may further include a therapeutic agent and be used to deliver the therapeutic agent to a cell. An oligonucleotide and therapeutic agent may be used together. For example, when the oligonucleotide is an siRNA, the composition may be used to decrease cellular resistance to the therapeutic agent by decreasing translation of a resistance gene.

公开(公告)号：US20180155189A1

公开(公告)日：2018-06-07

申请号：US15698486

申请日：2017-09-07

申请人： The Regents of the University of California

发明人： Jeffrey I. Zink ,  Andre E. Nel ,  Tian Xia ,  Zhaoxia Ji ,  Huan Meng ,  Zongxi Li ,  Monty Liong ,  Min Xue ,  Derrick Y. Tarn ,  Sanaz Kabehie

IPC分类号： B82Y5/00 ,  A61K31/713 ,  A61K9/00 ,  A61K9/51 ,  A61K31/704

CPC分类号： B82Y5/00 ,  A61K9/0019 ,  A61K9/5115 ,  A61K9/5146 ,  A61K9/5192 ,  A61K31/704 ,  A61K31/713 ,  Y10T428/2982 ,  A61K2300/00

摘要： A submicron structure having a silica body defining a plurality of pores is described. The submicron body may be spherical or non-spherical, and may include a cationic polymer or co-polymer on the surface of said silica body. The submicron structure may further include an oligonucleotide and be used to deliver the oligonucleotide to a cell. The submicron structure may further include a therapeutic agent and be used to deliver the therapeutic agent to a cell. An oligonucleotide and therapeutic agent may be used together. For example, when the oligonucleotide is an siRNA, the composition may be used to decrease cellular resistance to the therapeutic agent by decreasing translation of a resistance gene.