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公开(公告)号：US20190382265A1
公开(公告)日：2019-12-19
申请号：US16427253
申请日：2019-05-30
发明人： Jeffrey I. Zink , Andre E. Nel , Tian Xia , Zhaoxia Ji , Huan Meng , Zongxi Li , Monty Liong , Min Xue , Derrick Y. Tarn , Sanaz Gardner
IPC分类号： B82Y5/00 , A61K9/00 , A61K9/51 , A61K31/704 , A61K31/713
摘要： A submicron structure having a silica body defining a plurality of pores is described. The submicron body may be spherical or non-spherical, and may include a cationic polymer or co-polymer on the surface of said silica body. The submicron structure may further include an oligonucleotide and be used to deliver the oligonucleotide to a cell. The submicron structure may further include a therapeutic agent and be used to deliver the therapeutic agent to a cell. An oligonucleotide and therapeutic agent may be used together. For example, when the oligonucleotide is an siRNA, the composition may be used to decrease cellular resistance to the therapeutic agent by decreasing translation of a resistance gene.
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公开(公告)号：US10343903B2
公开(公告)日：2019-07-09
申请号：US15698486
申请日：2017-09-07
发明人： Jeffrey I. Zink , Andre E. Nel , Tian Xia , Zhaoxia Ji , Huan Meng , Zongxi Li , Monty Liong , Min Xue , Derrick Y. Tarn , Sanaz Gardner
IPC分类号： A61K9/14 , B82Y5/00 , A61K9/00 , A61K9/51 , A61K31/704 , A61K31/713
摘要： A submicron structure having a silica body defining a plurality of pores is described. The submicron body may be spherical or non-spherical, and may include a cationic polymer or co-polymer on the surface of said silica body. The submicron structure may further include an oligonucleotide and be used to deliver the oligonucleotide to a cell. The submicron structure may further include a therapeutic agent and be used to deliver the therapeutic agent to a cell. An oligonucleotide and therapeutic agent may be used together. For example, when the oligonucleotide is an siRNA, the composition may be used to decrease cellular resistance to the therapeutic agent by decreasing translation of a resistance gene.
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