公开(公告)号：US20220331365A1

公开(公告)日：2022-10-20

申请号：US17639895

申请日：2020-09-01

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Ronnie H. Fang ,  Jia Zhuang ,  Weiwei Gao

IPC: A61K35/18 ,  A61K9/127 ,  A61K31/02 ,  A61P9/10

Abstract: A biomimetic oxygen delivery carrier is provided by employing natural cell membrane as a stabilizer for fluorocarbon nanoemulsions. The resulting formulation exhibits a high capacity for delivering oxygen and can be used to successfully resuscitate subjects in need due to for example hemorrhagic shock. This natural-synthetic platform can alleviate the impact of blood shortages in clinical settings among other uses.

公开(公告)号：US20240316211A1

公开(公告)日：2024-09-26

申请号：US18614193

申请日：2024-03-22

Applicant: The Regents of the University of California

Inventor： Joseph Wang ,  Liangfang Zhang ,  Fangyu Zhang ,  Jia Zhuang

IPC: A61K47/69 ,  A61K9/00 ,  A61K31/496 ,  A61K31/704 ,  A61K47/54 ,  A61P31/04 ,  A61P35/00

CPC classification number: A61K47/6901 ,  A61K9/007 ,  A61K31/496 ,  A61K31/704 ,  A61K47/545 ,  A61K47/6937 ,  A61P31/04 ,  A61P35/00

Abstract: Microalgae combined with antibiotic-loaded neutrophil membrane-coated polymeric nanoparticles provide a hybrid microrobot having robust locomotion in the lungs in vivo toward effective treatment of pulmonary and gastrointestinal tract infections. The algae-nanoparticle hybrid microrobots are provided in methods of treatment of disease or conditions by administration for active in vivo delivery of therapeutics to the lungs or gastrointestinal tract. The microrobot system can be applied to treat a wide range of diseases, including viral pneumonia.