公开(公告)号：US20250023107A1

公开(公告)日：2025-01-16

申请号：US18900338

申请日：2024-09-27

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Cyrus Rustomji ,  Sungho Jin ,  Taekyoung Kim ,  Jungmin You ,  Joseph Wang ,  Duyoung Choi

IPC: H01M10/0569 ,  C25D3/42 ,  C25D3/44 ,  C25D3/50 ,  C25D3/54 ,  C25D5/00 ,  C25D9/08 ,  C25D17/02 ,  C25D21/00 ,  H01G11/22 ,  H01G11/46 ,  H01G11/60 ,  H01G11/62 ,  H01G11/78 ,  H01G11/86 ,  H01M4/38 ,  H01M10/052 ,  H01M10/0525 ,  H01M10/0564

Abstract: Disclosed are novel electrolytes, and techniques for making and devices using such electrolytes, which are based on compressed gas solvents. Unlike conventional electrolytes, disclosed electrolytes are based on “compressed gas solvents” mixed with various salts, referred to as “compressed gas electrolytes.” Various embodiments of a compressed gas solvent includes a material that is in a gas phase and has a vapor pressure above an atmospheric pressure at a room temperature. The disclosed compressed gas electrolytes can have wide electrochemical potential windows, high conductivity, low temperature capability and/or high pressure solvent properties. Examples of a class of compressed gases that can be used as solvent for electrolytes include hydrofluorocarbons, in particular fluoromethane, difluoromethane, tetrafluoroethane, pentafluoroethane. Also disclosed are battery and supercapacitor structures that use compressed gas solvent-based electrolytes, techniques for constructing such energy storage devices. Techniques for electroplating difficult-to-deposit materials using compressed gas electrolytes as an electroplating bath are also disclosed.

公开(公告)号：US12023154B2

公开(公告)日：2024-07-02

申请号：US16940356

申请日：2020-07-27

Applicant: The Regents of the University of California

Inventor： Joseph Wang ,  Amay Jairaj Bandodkar ,  Patrick Mercier

IPC: A61B5/1486 ,  A61B5/00 ,  A61B5/145 ,  G01N33/66

CPC classification number: A61B5/1486 ,  A61B5/14521 ,  A61B5/14532 ,  A61B5/6833 ,  A61B2562/00 ,  A61B2562/0215 ,  G01N33/66

Abstract: A non-invasive epidermal electrochemical sensor device includes an adhesive membrane; a flexible or stretchable substrate disposed over the adhesive membrane; and an anodic electrode assembly disposed over the flexible or stretchable substrate including an iontophoretic electrode. The device includes a cathodic electrode assembly disposed adjacent to the anodic electrode assembly over the flexible or stretchable substrate and includes an iontophoretic electrode. Either the cathodic electrode assembly or the anodic electrode assembly also includes a sensing electrode that includes a working electrode and at least one of a counter electrode or a reference electrode. The iontophoretic electrode in either the anodic electrode assembly or the cathodic electrode assembly that includes the sensing electrode is disposed on the substrate to at least partially encompass the working electrode and the at least one of the counter electrode or the reference electrode. The device includes an electrode interface assembly including independent electrically conductive contacts.

公开(公告)号：US20230320636A1

公开(公告)日：2023-10-12

申请号：US18313168

申请日：2023-05-05

Applicant: The Regents of the University of California

Inventor： Farshad Tehrani ,  Joseph Wang ,  Hazhir Teymourian

IPC: A61B5/1473 ,  A61B5/00

CPC classification number: A61B5/14735 ,  A61B5/0022 ,  A61B5/685 ,  A61B2562/046 ,  A61B2562/125

Abstract: Disclosed here are devices, systems, and methods for continuous monitoring of biomarkers using a wearable, non-intrusive microneedle sensor patch platform. In some aspects, a wearable, non-intrusive microneedle sensor device includes a microneedle sensor unit couplable to an electronics unit, where the microneedle sensor unit comprises a substrate, an array of spiked microneedle structures configured as electrochemical sensor electrodes, an array of base structures that encase a lower portion of spiked microneedle structures, and electrical interconnections that electrically couple the electrodes to the electronics unit for processing of detectable signals associated with one or multiple biomarkers in a biofluid.

公开(公告)号：US11684298B2

公开(公告)日：2023-06-27

申请号：US17860070

申请日：2022-07-07

Applicant: The Regents of the University of California

Inventor： Farshad Tehrani ,  Joseph Wang ,  Hazhir Teymourian

IPC: A61B5/1473 ,  A61B5/00

CPC classification number: A61B5/14735 ,  A61B5/0022 ,  A61B5/685 ,  A61B2562/046 ,  A61B2562/125

Abstract: Disclosed here are devices, systems, and methods for continuous monitoring of biomarkers using a wearable, non-intrusive microneedle sensor patch platform. In some aspects, a wearable, non-intrusive microneedle sensor device includes a microneedle sensor unit couplable to an electronics unit, where the microneedle sensor unit comprises a substrate, an array of spiked microneedle structures configured as electrochemical sensor electrodes, an array of base structures that encase a lower portion of spiked microneedle structures, and electrical interconnections that electrically couple the electrodes to the electronics unit for processing of detectable signals associated with one or multiple biomarkers in a biofluid.

公开(公告)号：US11185286B2

公开(公告)日：2021-11-30

申请号：US15806216

申请日：2017-11-07

Applicant: The Regents of the University of California

Inventor： Joseph Wang ,  Joshua Ray Windmiller ,  Amay Jairaj Bandodkar

IPC: A61B5/05 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1477 ,  A61B5/1486 ,  B32B37/12 ,  B32B38/10 ,  B32B38/00

Abstract: Methods, structures, devices and systems are disclosed for fabricating and implementing electrochemical biosensors and chemical sensors. In one aspect, a method of producing an epidermal biosensor includes forming an electrode pattern onto a coated surface of a paper-based substrate to form an electrochemical sensor, the electrode pattern including an electrically conductive material and an electrically insulative material configured in a particular design layout, and attaching an adhesive sheet on a surface of the electrochemical sensor having the electrode pattern, the adhesive sheet capable of adhering to skin or a wearable item, in which the electrochemical sensor, when attached to the skin or the wearable item, is operable to detect chemical analytes within an external environment.

公开(公告)号：US20210076988A1

公开(公告)日：2021-03-18

申请号：US16940356

申请日：2020-07-27

Applicant: The Regents of the University of California

Inventor： Joseph Wang ,  Amay Jairaj Bandodkar ,  Patrick Mercier

IPC: A61B5/1486 ,  A61B5/00 ,  A61B5/145

Abstract: A non-invasive epidermal electrochemical sensor device includes an adhesive membrane; a flexible or stretchable substrate disposed over the adhesive membrane; and an anodic electrode assembly disposed over the flexible or stretchable substrate including an iontophoretic electrode. The device includes a cathodic electrode assembly disposed adjacent to the anodic electrode assembly over the flexible or stretchable substrate and includes an iontophoretic electrode. Either the cathodic electrode assembly or the anodic electrode assembly also includes a sensing electrode that includes a working electrode and at least one of a counter electrode or a reference electrode. The iontophoretic electrode in either the anodic electrode assembly or the cathodic electrode assembly that includes the sensing electrode is disposed on the substrate to at least partially encompass the working electrode and the at least one of the counter electrode or the reference electrode. The device includes an electrode interface assembly including independent electrically conductive contacts.

公开(公告)号：US10851463B2

公开(公告)日：2020-12-01

申请号：US15967454

申请日：2018-04-30

Applicant: The Regents of the University of California

Inventor： Joseph Wang ,  Wei Gao ,  Sirilak Sattayasamitsathit

IPC: B01J23/42 ,  C25D1/02 ,  G01N33/487 ,  B82Y30/00 ,  A61K9/70 ,  A61K47/02 ,  A61K47/34 ,  B01J20/22 ,  B01J23/89 ,  B01J31/06 ,  B01J35/00 ,  B01J35/02 ,  B01J37/02 ,  C25D1/00 ,  C25D1/20 ,  C25D3/12 ,  B01J23/40 ,  B01J21/00 ,  B01J23/00 ,  B01J25/00 ,  B01J29/00 ,  B82Y15/00 ,  F03H99/00

Abstract: Methods, structures, devices and systems are disclosed for fabrication of microtube engines using membrane template electrodeposition. Such nanomotors operate based on bubble-induced propulsion in biological fluids and salt-rich environments. In one aspect, fabricating microengines includes depositing a polymer layer on a membrane template, depositing a conductive metal layer on the polymer layer, and dissolving the membrane template to release the multilayer microtubes.

公开(公告)号：US10758182B2

公开(公告)日：2020-09-01

申请号：US15806230

申请日：2017-11-07

Applicant: The Regents of the University of California

Inventor： Joseph Wang ,  Joshua Ray Windmiller

IPC: A61B5/1477 ,  A61B5/00 ,  A61B5/145 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0245 ,  C12Q1/00 ,  G01N27/30 ,  G01N33/22 ,  A61B5/1486 ,  A41D1/00 ,  G01N27/327 ,  G01N33/00 ,  H05K1/03 ,  H05K3/12

Abstract: Techniques and systems are disclosed for implementing textile-based screen-printed amperometric or potentiometric sensors. The chemical sensor can include carbon based electrodes to detect at least one of NADH, hydrogen peroxide, potassium ferrocyanide, TNT or DNT, in liquid or vapor phase. In one application, underwater presence of chemicals such as heavy metals and explosives is detected using the textile-based sensors.

公开(公告)号：US10722160B2

公开(公告)日：2020-07-28

申请号：US15531982

申请日：2015-12-03

Applicant: The Regents of the University of California

Inventor： Joseph Wang ,  Amay Jairaj Bandodkar ,  Patrick Mercier

IPC: A61B5/1486 ,  A61B5/00 ,  A61B5/145 ,  G01N33/66

Abstract: A non-invasive epidermal electrochemical sensor device includes an adhesive membrane; a flexible or stretchable substrate disposed over the adhesive membrane; and an anodic electrode assembly disposed over the flexible or stretchable substrate including an iontophoretic electrode. The device includes a cathodic electrode assembly disposed adjacent to the anodic electrode assembly over the flexible or stretchable substrate and includes an iontophoretic electrode. Either the cathodic electrode assembly or the anodic electrode assembly also includes a sensing electrode that includes a working electrode and at least one of a counter electrode or a reference electrode. The iontophoretic electrode in either the anodic electrode assembly or the cathodic electrode assembly that includes the sensing electrode is disposed on the substrate to at least partially encompass the working electrode and the at least one of the counter electrode or the reference electrode. The device includes an electrode interface assembly including independent electrically conductive contacts.

公开(公告)号：US20190117083A1

公开(公告)日：2019-04-25

申请号：US16090083

申请日：2017-04-03

Applicant: The Regents of the University of California

Inventor： Joseph Wang ,  Patrick Mercier

IPC: A61B5/0205 ,  A61B5/00

Abstract: Methods, systems, and devices are disclosed for wearable, real -time multimodal sensing of electrochemical and electrophysiological and/or physical parameters of a user. In some aspects, a multimodal sensor device includes a flexible substrate; an electrochemical sensor disposed on the substrate and including electrochemical sensing electrodes operable to measure an electrical signal corresponding to a reaction including a chemical substance via an electrochemical sensing electrode and an analyte at the electrochemical sensor; and an electrophysiological sensor including two or more electrodes disposed on the substrate to acquire an electrophysiological signal of the user, such that when the multimodal sensor device is electrically coupled to an electronics unit and adhered to the user, the device is operable to simultaneously monitor an electrochemical parameter and an electrophysiological parameter of the user.