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公开(公告)号：US12023154B2
公开(公告)日：2024-07-02
申请号：US16940356
申请日：2020-07-27
IPC分类号： A61B5/1486 , A61B5/00 , A61B5/145 , G01N33/66
CPC分类号： A61B5/1486 , A61B5/14521 , A61B5/14532 , A61B5/6833 , A61B2562/00 , A61B2562/0215 , G01N33/66
摘要： A non-invasive epidermal electrochemical sensor device includes an adhesive membrane; a flexible or stretchable substrate disposed over the adhesive membrane; and an anodic electrode assembly disposed over the flexible or stretchable substrate including an iontophoretic electrode. The device includes a cathodic electrode assembly disposed adjacent to the anodic electrode assembly over the flexible or stretchable substrate and includes an iontophoretic electrode. Either the cathodic electrode assembly or the anodic electrode assembly also includes a sensing electrode that includes a working electrode and at least one of a counter electrode or a reference electrode. The iontophoretic electrode in either the anodic electrode assembly or the cathodic electrode assembly that includes the sensing electrode is disposed on the substrate to at least partially encompass the working electrode and the at least one of the counter electrode or the reference electrode. The device includes an electrode interface assembly including independent electrically conductive contacts.
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公开(公告)号：US20230320636A1
公开(公告)日：2023-10-12
申请号：US18313168
申请日：2023-05-05
发明人： Farshad Tehrani , Joseph Wang , Hazhir Teymourian
IPC分类号： A61B5/1473 , A61B5/00
CPC分类号： A61B5/14735 , A61B5/0022 , A61B5/685 , A61B2562/046 , A61B2562/125
摘要： Disclosed here are devices, systems, and methods for continuous monitoring of biomarkers using a wearable, non-intrusive microneedle sensor patch platform. In some aspects, a wearable, non-intrusive microneedle sensor device includes a microneedle sensor unit couplable to an electronics unit, where the microneedle sensor unit comprises a substrate, an array of spiked microneedle structures configured as electrochemical sensor electrodes, an array of base structures that encase a lower portion of spiked microneedle structures, and electrical interconnections that electrically couple the electrodes to the electronics unit for processing of detectable signals associated with one or multiple biomarkers in a biofluid.
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公开(公告)号：US11684298B2
公开(公告)日：2023-06-27
申请号：US17860070
申请日：2022-07-07
发明人： Farshad Tehrani , Joseph Wang , Hazhir Teymourian
IPC分类号： A61B5/1473 , A61B5/00
CPC分类号： A61B5/14735 , A61B5/0022 , A61B5/685 , A61B2562/046 , A61B2562/125
摘要： Disclosed here are devices, systems, and methods for continuous monitoring of biomarkers using a wearable, non-intrusive microneedle sensor patch platform. In some aspects, a wearable, non-intrusive microneedle sensor device includes a microneedle sensor unit couplable to an electronics unit, where the microneedle sensor unit comprises a substrate, an array of spiked microneedle structures configured as electrochemical sensor electrodes, an array of base structures that encase a lower portion of spiked microneedle structures, and electrical interconnections that electrically couple the electrodes to the electronics unit for processing of detectable signals associated with one or multiple biomarkers in a biofluid.
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公开(公告)号：US11185286B2
公开(公告)日：2021-11-30
申请号：US15806216
申请日：2017-11-07
IPC分类号： A61B5/05 , A61B5/00 , A61B5/145 , A61B5/1477 , A61B5/1486 , B32B37/12 , B32B38/10 , B32B38/00
摘要： Methods, structures, devices and systems are disclosed for fabricating and implementing electrochemical biosensors and chemical sensors. In one aspect, a method of producing an epidermal biosensor includes forming an electrode pattern onto a coated surface of a paper-based substrate to form an electrochemical sensor, the electrode pattern including an electrically conductive material and an electrically insulative material configured in a particular design layout, and attaching an adhesive sheet on a surface of the electrochemical sensor having the electrode pattern, the adhesive sheet capable of adhering to skin or a wearable item, in which the electrochemical sensor, when attached to the skin or the wearable item, is operable to detect chemical analytes within an external environment.
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公开(公告)号：US20210076988A1
公开(公告)日：2021-03-18
申请号：US16940356
申请日：2020-07-27
IPC分类号： A61B5/1486 , A61B5/00 , A61B5/145
摘要： A non-invasive epidermal electrochemical sensor device includes an adhesive membrane; a flexible or stretchable substrate disposed over the adhesive membrane; and an anodic electrode assembly disposed over the flexible or stretchable substrate including an iontophoretic electrode. The device includes a cathodic electrode assembly disposed adjacent to the anodic electrode assembly over the flexible or stretchable substrate and includes an iontophoretic electrode. Either the cathodic electrode assembly or the anodic electrode assembly also includes a sensing electrode that includes a working electrode and at least one of a counter electrode or a reference electrode. The iontophoretic electrode in either the anodic electrode assembly or the cathodic electrode assembly that includes the sensing electrode is disposed on the substrate to at least partially encompass the working electrode and the at least one of the counter electrode or the reference electrode. The device includes an electrode interface assembly including independent electrically conductive contacts.
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公开(公告)号：US10851463B2
公开(公告)日：2020-12-01
申请号：US15967454
申请日：2018-04-30
发明人： Joseph Wang , Wei Gao , Sirilak Sattayasamitsathit
IPC分类号： B01J23/42 , C25D1/02 , G01N33/487 , B82Y30/00 , A61K9/70 , A61K47/02 , A61K47/34 , B01J20/22 , B01J23/89 , B01J31/06 , B01J35/00 , B01J35/02 , B01J37/02 , C25D1/00 , C25D1/20 , C25D3/12 , B01J23/40 , B01J21/00 , B01J23/00 , B01J25/00 , B01J29/00 , B82Y15/00 , F03H99/00
摘要： Methods, structures, devices and systems are disclosed for fabrication of microtube engines using membrane template electrodeposition. Such nanomotors operate based on bubble-induced propulsion in biological fluids and salt-rich environments. In one aspect, fabricating microengines includes depositing a polymer layer on a membrane template, depositing a conductive metal layer on the polymer layer, and dissolving the membrane template to release the multilayer microtubes.
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公开(公告)号：US10758182B2
公开(公告)日：2020-09-01
申请号：US15806230
申请日：2017-11-07
发明人： Joseph Wang , Joshua Ray Windmiller
IPC分类号： A61B5/1477 , A61B5/00 , A61B5/145 , A61B5/0205 , A61B5/021 , A61B5/024 , A61B5/0245 , C12Q1/00 , G01N27/30 , G01N33/22 , A61B5/1486 , A41D1/00 , G01N27/327 , G01N33/00 , H05K1/03 , H05K3/12
摘要： Techniques and systems are disclosed for implementing textile-based screen-printed amperometric or potentiometric sensors. The chemical sensor can include carbon based electrodes to detect at least one of NADH, hydrogen peroxide, potassium ferrocyanide, TNT or DNT, in liquid or vapor phase. In one application, underwater presence of chemicals such as heavy metals and explosives is detected using the textile-based sensors.
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公开(公告)号：US10722160B2
公开(公告)日：2020-07-28
申请号：US15531982
申请日：2015-12-03
IPC分类号： A61B5/1486 , A61B5/00 , A61B5/145 , G01N33/66
摘要： A non-invasive epidermal electrochemical sensor device includes an adhesive membrane; a flexible or stretchable substrate disposed over the adhesive membrane; and an anodic electrode assembly disposed over the flexible or stretchable substrate including an iontophoretic electrode. The device includes a cathodic electrode assembly disposed adjacent to the anodic electrode assembly over the flexible or stretchable substrate and includes an iontophoretic electrode. Either the cathodic electrode assembly or the anodic electrode assembly also includes a sensing electrode that includes a working electrode and at least one of a counter electrode or a reference electrode. The iontophoretic electrode in either the anodic electrode assembly or the cathodic electrode assembly that includes the sensing electrode is disposed on the substrate to at least partially encompass the working electrode and the at least one of the counter electrode or the reference electrode. The device includes an electrode interface assembly including independent electrically conductive contacts.
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公开(公告)号：US20190117083A1
公开(公告)日：2019-04-25
申请号：US16090083
申请日：2017-04-03
发明人： Joseph Wang , Patrick Mercier
IPC分类号： A61B5/0205 , A61B5/00
摘要： Methods, systems, and devices are disclosed for wearable, real -time multimodal sensing of electrochemical and electrophysiological and/or physical parameters of a user. In some aspects, a multimodal sensor device includes a flexible substrate; an electrochemical sensor disposed on the substrate and including electrochemical sensing electrodes operable to measure an electrical signal corresponding to a reaction including a chemical substance via an electrochemical sensing electrode and an analyte at the electrochemical sensor; and an electrophysiological sensor including two or more electrodes disposed on the substrate to acquire an electrophysiological signal of the user, such that when the multimodal sensor device is electrically coupled to an electronics unit and adhered to the user, the device is operable to simultaneously monitor an electrochemical parameter and an electrophysiological parameter of the user.
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公开(公告)号：US10143081B2
公开(公告)日：2018-11-27
申请号：US15820284
申请日：2017-11-21
发明人： Joseph Wang , Rajan Kumar , Ying Shirley Meng , Jae Wook Shin , Lu Yin
IPC分类号： H05K1/00 , H05K1/02 , C08F297/04 , H05K1/03 , H05K1/11 , H05K1/16 , H05K3/32 , C08L53/02 , A61B5/1477 , H05K5/00 , H05K7/00 , C01B32/158 , A61B5/1486 , A61F13/49 , H01M10/0565
摘要： Disclosed are compositions, devices, systems and fabrication methods for stretchable composite materials and stretchable electronics devices. In some aspects, an elastic composite material for a stretchable electronics device includes a first material having a particular electrical, mechanical or optical property; and a multi-block copolymer configured to form a hyperelastic binder that creates contact between the first material and the multi-block copolymer, in which the elastic composite material is structured to stretch at least 500% in at least one direction of the material and to exhibit the particular electrical, mechanical or optical property imparted from the first material. In some aspects, the stretchable electronics device includes a stretchable battery, biofuel cell, sensor, supercapacitor or other device able to be mounted to skin, clothing or other surface of a user or object.
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