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公开(公告)号：US20180153821A1
公开(公告)日：2018-06-07
申请号：US15737566
申请日：2016-06-07
发明人： Liangfang Zhang , Che-Ming Jack Hu , Ronnie H. Fang , Brian T. Luk , Kuei-Chun Wang , Shu Chien
IPC分类号： A61K9/51 , A61P7/04 , A61P9/00 , A61P35/00 , A61K31/337
CPC分类号： A61K9/5176 , A61K9/5153 , A61K9/5169 , A61K31/337 , A61K47/6901 , A61P7/04 , A61P9/00 , A61P35/00 , B82Y5/00 , B82Y30/00
摘要： The present invention relates to prevention and/or treatment of diseases or disorders associated with a damaged or leaky vasculature in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating a disease or disorder associated with a damaged or leaky vasculature in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, an outer surface comprising a cellular membrane derived from a platelet; and optionally an agent for preventing, treating, diagnosing, or prognosing the disease or disorder and/or monitoring prevention or treatment of the disease or disorder. Exemplary diseases or disorders include hemorrhage (bleeding), cardiovascular diseases or disorders, diseases or disorders associated with narrowing of a blood vessel, tumors or cancers.
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公开(公告)号：US20220151948A1
公开(公告)日：2022-05-19
申请号：US17590684
申请日：2022-02-01
发明人： Liangfang Zhang , Che-Ming Jack Hu , Ronnie H. Fang , Brian T. Luk , Kuei-Chun Wang , Shu Chien
摘要： The present invention relates to prevention and/or treatment of diseases or disorders associated with a damaged or leaky vasculature in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating a disease or disorder associated with a damaged or leaky vasculature in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, an outer surface comprising a cellular membrane derived from a platelet; and optionally an agent for preventing, treating, diagnosing, or prognosing the disease or disorder and/or monitoring prevention or treatment of the disease or disorder. Exemplary diseases or disorders include hemorrhage (bleeding), cardiovascular diseases or disorders, diseases or disorders associated with narrowing of a blood vessel, tumors or cancers.
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公开(公告)号：US11241394B2
公开(公告)日：2022-02-08
申请号：US15737566
申请日：2016-06-07
发明人： Liangfang Zhang , Che-Ming Jack Hu , Ronnie H. Fang , Brian T. Luk , Kuei-Chun Wang , Shu Chien
摘要： The present invention relates to prevention and/or treatment of diseases or disorders associated with a damaged or leaky vasculature in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating a disease or disorder associated with a damaged or leaky vasculature in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, an outer surface comprising a cellular membrane derived from a platelet; and optionally an agent for preventing, treating, diagnosing, or prognosing the disease or disorder and/or monitoring prevention or treatment of the disease or disorder. Exemplary diseases or disorders include hemorrhage (bleeding), cardiovascular diseases or disorders, diseases or disorders associated with narrowing of a blood vessel, tumors or cancers.
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