公开(公告)号：US12297241B2

公开(公告)日：2025-05-13

申请号：US17257951

申请日：2019-07-03

Applicant: The Regents of the University of California

Inventor： Kun Zhang ,  Yan Wu ,  Amir Dailamy ,  Prashant Mali ,  Daniella McDonald ,  Udit Parekh ,  Michael Hu

IPC: C07K14/47 ,  A61K31/522 ,  A61K45/06 ,  C12N5/071 ,  C12N9/22 ,  C12N15/11 ,  C12N15/86

Abstract: This disclosure relates to methods, polynucleotides, vectors, viral particles, cells, and systems or the engineering of human tissues. One aspect of the disclosure relates to using lineage-specific miRNA binding molecules to bias tissue lineage. Another aspect of the disclosure relates to using lineage-specific transcription factor overexpression to bias tissue lineage.

公开(公告)号：US20220235104A1

公开(公告)日：2022-07-28

申请号：US17257951

申请日：2019-07-03

Applicant: The Regents of the University of California

Inventor： Kun Zhang ,  Yan Wu ,  Amir Dailamy ,  Prashant Mali ,  Daniella McDonald ,  Udit Parekh ,  Michael Hu

IPC: C07K14/47 ,  A61K31/522 ,  A61K45/06 ,  C12N15/86 ,  C12N5/071 ,  C12N15/11 ,  C12N9/22

Abstract: This disclosure relates to methods, polynucleotides, vectors, viral particles, cells, and systems or the engineering of human tissues. One aspect of the disclosure relates to using lineage-specific miRNA binding molecules to bias tissue lineage. Another aspect of the disclosure relates to using lineage-specific transcription factor overexpression to bias tissue lineage.