公开(公告)号：US09289500B2

公开(公告)日：2016-03-22

申请号：US14186973

申请日：2014-02-21

申请人： The Regents of the University of California ,  City of Hope

发明人： Zhibin Guan ,  Yoko Mullen ,  Sophia W. Liao

IPC分类号： A61K9/00 ,  A61K47/42 ,  A61K47/26 ,  A61K9/06 ,  A61K47/48

CPC分类号： A61K47/42 ,  A61K9/0024 ,  A61K9/06 ,  A61K47/26 ,  A61K47/48192 ,  A61K47/4823 ,  A61K47/48784 ,  A61K47/59 ,  A61K47/61 ,  A61K47/6903

摘要： The disclosure provides for saccharide-peptide based hydrogels, the functionalization of the saccharide-peptide based hydrogels with one or more biological agents, and the encapsulation of one or more biological materials and/or pharmaceutical agents in the hydrogels. The disclosure further provides for the use of the saccharide-peptide based hydrogels in treating a disease or disorder in a subject.

摘要翻译： 本公开提供了基于糖 - 肽的水凝胶，用一种或多种生物制剂对糖 - 肽基水凝胶的官能化，以及一种或多种生物材料和/或药剂在水凝胶中的包封。 本公开进一步提供了基于糖 - 肽的水凝胶在治疗受试者的疾病或病症中的用途。

公开(公告)号：US20140242123A1

公开(公告)日：2014-08-28

申请号：US14186973

申请日：2014-02-21

申请人： City of Hope ,  The Regents of the University of California

发明人： Zhibin Guan ,  Yoko Mullen ,  Sophia W. Liao

IPC分类号： A61K47/48 ,  A61K9/00 ,  A61K47/34 ,  A61K47/42

CPC分类号： A61K47/42 ,  A61K9/0024 ,  A61K9/06 ,  A61K47/26 ,  A61K47/48192 ,  A61K47/4823 ,  A61K47/48784 ,  A61K47/59 ,  A61K47/61 ,  A61K47/6903

摘要： The disclosure provides for saccharide-peptide based hydrogels, the functionalization of the saccharide-peptide based hydrogels with one or more biological agents, and the encapsulation of one or more biological materials and/or pharmaceutical agents in the hydrogels. The disclosure further provides for the use of the saccharide-peptide based hydrogels in treating a disease or disorder in a subject.

摘要翻译： 本公开提供了基于糖 - 肽的水凝胶，用一种或多种生物制剂对糖 - 肽基水凝胶的官能化，以及一种或多种生物材料和/或药剂在水凝胶中的包封。 本公开进一步提供了基于糖 - 肽的水凝胶在治疗受试者的疾病或病症中的用途。

公开(公告)号：US20230043444A1

公开(公告)日：2023-02-09

申请号：US17857554

申请日：2022-07-05

申请人： The Regents of the University of California

发明人： Chase Tretbar ,  Zhibin Guan ,  Jordan A. Castro

IPC分类号： C08J3/24 ,  C08F120/14 ,  C08F110/02 ,  C08F110/06

摘要： A vitrimer composition includes a first plurality of polymer backbones cross-linked with cross-linkers that include at least one siloxane moiety having formula 1: wherein R1, R2, R3, and R4 are each independently H or C1-6 alkyl. A catalyst that accelerates siloxane exchange is dispersed within the first plurality of polymer backbones.

公开(公告)号：US20230039491A1

公开(公告)日：2023-02-09

申请号：US17857842

申请日：2022-07-05

申请人： The Regents of the University of California

发明人： Chase Tretbar ,  Zhibin Guan

IPC分类号： C08L23/06

摘要： A polymer composition that operates as a polymer compatibilizer is provided. The polymer composition includes a plurality of polymer backbones cross-linked by cross-links that are Diels-Alder reaction products of at least one dienophile-containing moiety and at least one diene-containing moiety.

公开(公告)号：US20190070304A1

公开(公告)日：2019-03-07

申请号：US16084220

申请日：2017-03-10

申请人： The Regents of the University of California

发明人： Zhibin Guan ,  Nathan Oldenhuis

IPC分类号： A61K47/64 ,  C08G75/14 ,  C12N15/11 ,  C12N15/87

摘要： The disclosure provides for vectors, and methods of using the vectors to efficiently deliver mRNA and/or ssRNA into cells.

公开(公告)号：US20160030590A1

公开(公告)日：2016-02-04

申请号：US14814475

申请日：2015-07-30

申请人： The Regents of the University of California

发明人： Zhibin Guan ,  Hanxiang Zeng ,  Mark Edward Johnson

IPC分类号： A61K47/48 ,  C12N15/113 ,  A61K31/713 ,  C07K5/097

CPC分类号： A61K31/713 ,  A61K47/60 ,  A61K47/645 ,  C07K5/0215 ,  C12N15/111 ,  C12N2310/14 ,  C12N2320/32

摘要： The disclosure provides for peptide-based bolaamphiphile vectors that are capable of encapsulating a variety of agents, including peptides, proteins, nucleic acids, and drugs. The disclosure further provides for delivering these agents across biological membranes using the peptide-based bolaamphiphile vectors.

摘要翻译： 本公开提供了能够包封多种试剂（包括肽，蛋白质，核酸和药物）的基于肽的bolaamphophile载体。 本公开进一步提供使用基于肽的bolaamphphileile载体将这些试剂递送到生物膜上。

公开(公告)号：US20220183990A1

公开(公告)日：2022-06-16

申请号：US17432077

申请日：2020-02-21

申请人： The Regents of the University of California

发明人： Zhibin Guan ,  Dongchu Yang ,  Alexander Eldredge

IPC分类号： A61K9/51 ,  A61K31/7105 ,  A61K31/713 ,  A61K47/59 ,  A61K47/64 ,  A61K9/08 ,  A61K9/48

摘要： The disclosure provides for peptide-functionalized biodegradable polymers, and methods of using the polymers for efficiently delivering RNAs of various sizes, and secondary structures inside cells.

公开(公告)号：US20180371183A1

公开(公告)日：2018-12-27

申请号：US16019500

申请日：2018-06-26

申请人： The Regents of the University of California

发明人： Zhibin Guan

IPC分类号： C08J3/24

摘要： The disclosure provides for dynamic polymers based on silyl ether exchange that are malleable and recyclable which have favorable mechanical properties and chemical resistance, methods of making thereof, and uses and applications thereof.

公开(公告)号：US20180072849A1

公开(公告)日：2018-03-15

申请号：US15688718

申请日：2017-08-28

申请人： The Regents of the University of California

发明人： Zhibin Guan ,  Hanxiang Zeng

IPC分类号： C08G75/14 ,  C12N15/87 ,  C12N15/11

CPC分类号： C08G75/14 ,  C12N15/111 ,  C12N15/87 ,  C12N2310/14 ,  C12N2320/32

摘要： The disclosure provides for dendronized polymers, and the use of the polymers as carriers for the intracellular delivery of nucleic acids.

公开(公告)号：US09745421B2

公开(公告)日：2017-08-29

申请号：US14221249

申请日：2014-03-20

申请人： The Regents of the University of California

发明人： Zhibin Guan ,  Hanxiang Zeng

IPC分类号： C12N15/87 ,  C08G75/14 ,  C12N15/11

CPC分类号： C08G75/14 ,  C12N15/111 ,  C12N15/87 ,  C12N2310/14 ,  C12N2320/32

摘要： The disclosure provides for dendronized polymers, and the use of the polymers as carriers for the intracellular delivery of nucleic acids.