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公开(公告)号：US20230346943A1
公开(公告)日：2023-11-02
申请号：US17793806
申请日：2021-01-20
CPC分类号： A61K41/0042 , A61K47/545 , A61K47/549 , A61K49/0002
摘要： Provided herein, inter alia, are methods and compositions useful for treating a disease.
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公开(公告)号：US20220411496A1
公开(公告)日：2022-12-29
申请号：US17714051
申请日：2022-04-05
IPC分类号： C07K16/28 , C07K16/30 , C07K16/24 , C12N5/071 , C12N5/0784 , C12N5/0786 , C12N5/09 , G01N33/569
摘要： Provided herein are methods and compositions for enhancing an immune response and/or for the treatment of an immune-related condition in an individual, e.g., cancer, comprising killing, disabling, or depleting non-stimulatory myeloid cells using an antigen binding protein such as an antibody or antigen binding fragment thereof.
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公开(公告)号：US11325973B2
公开(公告)日：2022-05-10
申请号：US16459589
申请日：2019-07-01
IPC分类号： A61K39/00 , C07K16/28 , C07K16/30 , C07K16/24 , C12N5/071 , C12N5/0784 , C12N5/0786 , C12N5/09 , G01N33/569
摘要： Provided herein are methods and compositions for enhancing an immune response and/or for the treatment of an immune-related condition in an individual, e.g., cancer, comprising killing, disabling, or depleting non-stimulatory myeloid cells using an antigen binding protein such as an antibody or antigen binding fragment thereof.
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公开(公告)号：US20200017584A1
公开(公告)日：2020-01-16
申请号：US16459589
申请日：2019-07-01
IPC分类号： C07K16/28 , C07K16/24 , C12N5/071 , C12N5/0784 , C12N5/0786 , C12N5/09 , G01N33/569 , C07K16/30
摘要： Provided herein are methods and compositions for enhancing an immune response and/or for the treatment of an immune-related condition in an individual, e.g., cancer, comprising killing, disabling, or depleting non-stimulatory myeloid cells using an antigen binding protein such as an antibody or antigen binding fragment thereof.
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公开(公告)号：US20170291946A1
公开(公告)日：2017-10-12
申请号：US15514471
申请日：2015-09-28
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/243 , C07K16/2818 , C07K16/2863 , C07K16/30 , C07K16/3046 , C07K16/3053 , C07K2317/73 , C07K2317/76 , C12N5/0626 , C12N5/0639 , C12N5/0645 , C12N5/0693 , G01N33/56966
摘要： Provided herein are methods and compositions for enhancing an immune response and/or for the treatment of an immune-related condition in an individual, e.g., cancer, comprising killing, disabling, or depleting non-stimulatory myeloid cells using an antigen binding protein such as an antibody or antigen binding fragment thereof.
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公开(公告)号：US20210198722A1
公开(公告)日：2021-07-01
申请号：US17057569
申请日：2019-05-21
IPC分类号： C12Q1/6816 , B01L3/00
摘要： Methods of tagging cells with unique oligonucleotide “zipcode” constructs are provided. By these methods and associated compositions, cells in a multicellular structure such as a tissue section can be tagged with a construct, the unique composition of which is associated with the cells position in the multicellular structure. Subsequently, the multicellular structure can be dissociated into single cells and a single cell transcriptome analysis performed, as well as other types of single cell analyses. By preserving positional information in the analyzed single cells, biological processes within the tissue can be mapped. By these methods, the effects of the local environment surrounding a cell on its state and various functions can be elucidated, and intra-tissue processes can be mapped and observed. Likewise, coordinated actions by multiple cells within a tissue can be mapped and tracked over time.
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公开(公告)号：US10428143B2
公开(公告)日：2019-10-01
申请号：US15514471
申请日：2015-09-28
IPC分类号： A61K39/00 , C07K16/28 , C07K16/24 , C07K16/30 , C12N5/071 , C12N5/0784 , C12N5/0786 , C12N5/09 , G01N33/569
摘要： Provided herein are methods and compositions for enhancing an immune response and/or for the treatment of an immune-related condition in an individual, e.g., cancer, comprising killing, disabling, or depleting non-stimulatory myeloid cells using an antigen binding protein such as an antibody or antigen binding fragment thereof.
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