专利检索 ap:("The Regents of the University of California" OR "The Scripps Research Institute") AND inv:"Eduardo Laborda" 第 1 页

1.

发明申请
Switchable Chimeric Antigen Receptor-Engineered Human Natural Killer Cells 有权

公开(公告)号：US20220152110A1

公开(公告)日：2022-05-19

申请号：US17441653

申请日：2020-03-23

申请人： The Regents of the University of California , The Scripps Research Institute

发明人： Dan S. Kaufman , Xiao-Hua Li , Eduardo Laborda , Travis Young

IPC分类号： A61K35/17 , C07K14/725 , C07K16/30 , C07K14/705 , C07K16/28 , A61P35/00

摘要： Engineered natural killer cells with switchable chimeric antigen receptor, methods of manufacture, pharmaceutical compositions, and methods of use in treating cancer and viral infection.

2.

发明授权
Chimeric antigen receptor effector cell switches with humanized targeting moieties and/or optimized chimeric antigen receptor interacting domains and uses thereof 有权

公开(公告)号：US11174306B2

公开(公告)日：2021-11-16

申请号：US16343353

申请日：2017-10-19

申请人： The Scripps Research Institute

发明人： Travis S. Young , Leonard Presta , David Rodgers , Eric Hampton , Timothy Wright , Peter G. Schultz , Eduardo Laborda , Elvira Khialeeva , Sophie Viaud

IPC分类号： C07K16/18 , A61P35/00 , C07K14/725 , C07K14/705 , C07K16/28 , A61K39/00

摘要： The present disclosure provides compositions, methods, kits, and platforms for selectively activating and deactivating chimeric receptor effector cells using humanized chimeric receptor effector cell switches that comprise a humanized targeting moiety that binds CD19 on a target cell and a chimeric receptor interacting domain that binds to a chimeric receptor effector cell and/or chimeric receptor effector cell switches comprising optimized chimeric receptor interacting domains. Also disclosed are methods of treating disease and conditions with such chimeric receptor effector cells and chimeric receptor effector cell switches.

3.

发明授权
Optimized PNE-based chimeric receptor T cell switches and uses thereof 有权

公开(公告)号：US11091546B2

公开(公告)日：2021-08-17

申请号：US15566680

申请日：2016-04-15

申请人： The Scripps Research Institute

发明人： Travis Young , David T. Rodgers , Ian Hardy , Chanhyuk Kim , Peter G. Schultz , Eric Hampton , Eduardo Laborda , Leonard Presta

IPC分类号： C07K16/28 , A61K35/17 , C07K16/18 , C07K16/32 , A61P35/00 , C07K14/39 , A61K39/00

摘要： Disclosed herein are chimeric antigen receptor effector cells (CAR-ECs) and CAR-EC switches. The switchable CAR-ECs are generally T cells. The one or more chimeric antigen receptors may recognize a peptidic antigen on the CAR-EC switch. The CAR-ECs and switches may be used for the treatment of a condition in a subject in need thereof.