公开(公告)号：US20210317157A1

公开(公告)日：2021-10-14

申请号：US17224728

申请日：2021-04-07

申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

发明人： Robert D. Kuchta ,  Ayman Alawneh

IPC分类号： C07H19/23 ,  C07D471/04 ,  C07D487/04 ,  C07H21/02 ,  C07H21/04

摘要： The present disclosure includes nucleosides and/or nucleotides comprising an optionally substituted alloxazine (also known as benzo[g]pteridine-2,4(1H,3H)-dione, or isoalloxazine) at the anomeric position.

公开(公告)号：US12030911B2

公开(公告)日：2024-07-09

申请号：US17251608

申请日：2019-06-14

申请人： The Regents of the University of Colorado, a body corporate

发明人： Ayman Alawneh ,  Marvin Caruthers

IPC分类号： C07H21/04 ,  C07H1/00 ,  C07H19/073

CPC分类号： C07H21/04 ,  C07H1/00 ,  C07H19/073

摘要： Oligonucleotides comprising phosphoramidimidate internucleotide linkages, and methods of efficiently synthesizing these oligonucleotides with high yield are provided. These oligonucleotides form duplexes with complementary DNA or RNA that are more stable than natural DNA or DNA/RNA complexes, are active with RNAse H1, and may be transfected into cells using standard lipid reagents. These analogues are therefore useful for numerous therapeutic antisense applications.

公开(公告)号：US20210277047A1

公开(公告)日：2021-09-09

申请号：US17251608

申请日：2019-06-14

申请人： The Regents of the University of Colorado, a body corporate

发明人： Ayman Alawneh ,  Marvin Caruthers

IPC分类号： C07H21/04 ,  C07H1/00

摘要： Oligonucleotides comprising phosphoramidimidate internucleotide linkages, and methods of efficiently synthesizing these oligonucleotides with high yield are provided. These oligonucleotides form duplexes with complementary DNA or RNA that are more stable than natural DNA or DNA/RNA complexes, are active with RNAse H1, and may be transfected into cells using standard lipid reagents. These analogues are therefore useful for numerous therapeutic antisense applications.