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1.发明申请CYCLIZED PEPTIDOMIMETIC SMALL MOLECULE INHIBITORS OF THE WDR5 AND MLL1 INTERACTION 有权WDR5和MLL1相互作用的环化小分子抑制剂公开(公告)号：US20130150309A1
公开(公告)日：2013-06-13
申请号：US13686475
申请日：2012-11-27
Applicant: The Regents of the University of Michigan
Inventor： Shaomeng Wang , Hacer Karatas , Yali Dou , Elizabeth Townsend , Denzil Bernard , Fang Cao
IPC: C07K5/12 , A61N5/10 , C07D255/02 , A61K38/12 , A61K45/00
CPC classification number: C07K5/126 , A61K38/12 , A61K45/00 , A61K45/06 , A61N5/10 , A61N2005/1098 , C07D255/02 , C07K5/0207 , C07K5/021 , C07K5/0215 , C07K5/06034 , C07K5/0815 , C07K5/101 , C07K5/1019 , C07K5/123 , A61K2300/00
Abstract: Cyclic peptidomimetics that inhibit the interaction between MLL1 and WDR5 are disclosed. Methods of inhibiting MLL1 activity and methods of treating cancers also are disclosed.
Abstract translation: 公开了抑制MLL1和WDR5之间相互作用的循环肽模拟物。 还公开了抑制MLL1活性的方法和治疗癌症的方法。
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2.发明授权Cyclized peptidomimetic small molecule inhibitors of the WDR5 and MLL1 interaction 有权环化的拟肽小分子抑制剂WDR5和MLL1相互作用公开(公告)号：US08980838B2
公开(公告)日：2015-03-17
申请号：US13686475
申请日：2012-11-27
Applicant: The Regents of the University of Michigan
Inventor： Shaomeng Wang , Hacer Karatas , Yali Dou , Elizabeth Townsend , Denzil Bernard , Fang Cao
IPC: A61K38/12 , A61P35/00 , C07K5/12 , A61K45/00 , A61N5/10 , C07D255/02 , C07K5/02 , C07K5/09 , C07K5/103 , C07K5/11 , C07K5/062 , A61K45/06
CPC classification number: C07K5/126 , A61K38/12 , A61K45/00 , A61K45/06 , A61N5/10 , A61N2005/1098 , C07D255/02 , C07K5/0207 , C07K5/021 , C07K5/0215 , C07K5/06034 , C07K5/0815 , C07K5/101 , C07K5/1019 , C07K5/123 , A61K2300/00
Abstract: Cyclic peptidomimetics that inhibit the interaction between MLL1 and WDR5 are disclosed. Methods of inhibiting MLL1 activity and methods of treating cancers also are disclosed.
Abstract translation: 公开了抑制MLL1和WDR5之间相互作用的循环肽模拟物。 还公开了抑制MLL1活性的方法和治疗癌症的方法。
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