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公开(公告)号：US11944626B2
公开(公告)日：2024-04-02
申请号：US16311533
申请日：2017-06-20
Applicant: The Regents of the University of Michigan , Indiana University Research and Technology Corporation
Inventor： Scott D. Larsen , Brandt C. Huddle , Kun Yang , Ronald Buckanovich , Thomas Hurley
IPC: A61K31/519 , A61K31/337 , A61K31/4745 , A61K31/522 , A61K31/555 , A61K31/7068 , A61K39/395 , A61K45/06 , A61P31/00 , A61P35/00 , C07D487/04
CPC classification number: A61K31/519 , A61K31/337 , A61K31/4745 , A61K31/522 , A61K31/555 , A61K31/7068 , A61K39/395 , A61K45/06 , A61P31/00 , A61P35/00 , C07D487/04 , A61K31/522 , A61K2300/00 , A61K31/555 , A61K2300/00 , A61K31/337 , A61K2300/00 , A61K31/4745 , A61K2300/00 , A61K31/7068 , A61K2300/00
Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a thiopyrimidinone structure which function as inhibitors of ALDH protein, and their use as therapeutics for the treatment of cancer and other diseases.
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公开(公告)号：US09468632B2
公开(公告)日：2016-10-18
申请号：US14647770
申请日：2013-11-26
Applicant: The Regents of the University of Michigan
Inventor： Ronald Buckanovich , Scott D. Larsen , Kun Yang
IPC: A61K31/404 , A61K31/4439 , A61K45/06 , A61K31/337 , A61K31/555 , A61K33/24 , C07D401/04 , C07D471/04 , C07D209/04 , G01N33/574 , A61K31/136 , A61K31/4035 , A61K31/437
CPC classification number: A61K31/4439 , A61K31/136 , A61K31/337 , A61K31/4035 , A61K31/404 , A61K31/437 , A61K31/555 , A61K33/24 , A61K45/06 , C07D209/04 , C07D401/04 , C07D471/04 , G01N33/574 , A61K2300/00
Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides compounds as therapeutic agents against cancer stem cells.
Abstract translation: 本发明涉及化学化合物，其发现方法及其治疗和研究用途。 特别地，本发明提供了作为抗癌干细胞的治疗剂的化合物。
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公开(公告)号：US20150297577A1
公开(公告)日：2015-10-22
申请号：US14647770
申请日：2013-11-26
Applicant: The Regents of the University of Michigan
Inventor： Ronald Buckanovich , Scott D. Larsen , Kun Yang
IPC: A61K31/4439 , A61K45/06 , A61K31/437 , A61K31/136 , A61K31/4035
CPC classification number: A61K31/4439 , A61K31/136 , A61K31/337 , A61K31/4035 , A61K31/404 , A61K31/437 , A61K31/555 , A61K33/24 , A61K45/06 , C07D209/04 , C07D401/04 , C07D471/04 , G01N33/574 , A61K2300/00
Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides compounds as therapeutic agents against cancer stem cells.
Abstract translation: 本发明涉及化学化合物，其发现方法及其治疗和研究用途。 特别地，本发明提供了作为抗癌干细胞的治疗剂的化合物。
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公开(公告)号：US20190255055A1
公开(公告)日：2019-08-22
申请号：US16311533
申请日：2017-06-20
Applicant: The Regents of the University of Michigan , Indiana University Research and Technology Corporation
Inventor： Scott D. Larsen , Brandt C. Huddle , Kun Yang , Ronald Buckanovich , Thomas Hurley
IPC: A61K31/519 , A61P31/00 , A61P35/00 , A61K45/06 , C07D487/04
Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a thiopyrimidinone structure which function as inhibitors of ALDH protein, and their use as therapeutics for the treatment of cancer and other diseases.
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