公开(公告)号：US20140378680A1

公开(公告)日：2014-12-25

申请号：US14485054

申请日：2014-09-12

Applicant: The Regents of the University of Michigan

Inventor： Shaomeng Wang ,  Shanghai Yu ,  Wei Sun ,  SanJeev Kumar ,  Duxin Sun ,  Peng Zou ,  Donna McEachern ,  Yujun Zhao

IPC: C07D487/10 ,  C07D471/20 ,  C07F9/6561

CPC classification number: C07D487/10 ,  A61K31/407 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/675 ,  A61K45/06 ,  C07D471/20 ,  C07D491/107 ,  C07D495/10 ,  C07F9/6561 ,  A61K2300/00

Abstract: Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.