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公开(公告)号：US11173207B2
公开(公告)日：2021-11-16
申请号：US16302074
申请日：2017-05-19
IPC分类号： A61K39/39 , A61P37/04 , A61K39/385 , A61K39/295 , A61K39/00 , A61K9/107
摘要： The present invention provides methods and compositions for the stimulation of immune responses. In particular, the invention provides methods and compositions for enhancing an immune response to one or more antigens. Compositions and methods of the invention are useful for the treatment and/or prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites, as well as the treatment and/or prevention of cancer and malignant diseases. Compositions and methods of the invention include one or more antigens/immunogens together with an adjuvant formulation comprising an emulsion delivery system in combination with one or more immunostimulatory compounds (e.g., a compound that stimulates the innate immune system (e.g., a toll-like receptor antagonist (e.g., synthetic oligodeoxynucleotides (ODN)))) that enhance immune responses to the one or more antigens/immunogens when administered to a subject. Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.
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公开(公告)号：US20190282693A1
公开(公告)日：2019-09-19
申请号：US16302074
申请日：2017-05-19
摘要： The present invention provides methods and compositions for the stimulation of immune responses. In particular, the invention provides methods and compositions for enhancing an immune response to one or more antigens. Compositions and methods of the invention are useful for the treatment and/or prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites, as well as the treatment and/or prevention of cancer and malignant diseases. Compositions and methods of the invention include one or more antigens/immunogens together with an adjuvant formulation comprising an emulsion delivery system in combination with one or more immunostimulatory compounds (e.g., a compound that stimulates the innate immune system (e.g., a toll-like receptor antagonist (e.g., synthetic oligodeoxynucleotides (ODN)))) that enhance immune responses to the one or more antigens/immunogens when administered to a subject. Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.
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公开(公告)号：US20220282657A1
公开(公告)日：2022-09-08
申请号：US17526509
申请日：2021-11-15
IPC分类号： F01N3/28
摘要： The present invention provides methods and compositions for the stimulation of immune responses. In particular, the invention provides methods and compositions for enhancing an immune response to one or more antigens. Compositions and methods of the invention are useful for the treatment and/or prevention of microbial infections, such as infections caused by bacteria, viruses, fungi, and parasites, as well as the treatment and/or prevention of cancer and malignant diseases. Compositions and methods of the invention include one or more antigens/immunogens together with an adjuvant formulation comprising an emulsion delivery system in combination with one or more immunostimulatory compounds (e.g., a compound that stimulates the innate immune system (e.g., a toll-like receptor antagonist (e.g., synthetic oligodeoxynucleotides (ODN)))) that enhance immune responses to the one or more antigens/immunogens when administered to a subject. Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.
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公开(公告)号：US12076397B2
公开(公告)日：2024-09-03
申请号：US16300423
申请日：2017-05-10
IPC分类号： A61K39/395 , A61K9/00 , A61K9/107 , A61K38/38 , A61K39/12 , A61K39/145 , A61K39/39 , A61K47/10 , A61K47/18 , A61K47/26 , A61K47/34 , A61K39/00
CPC分类号： A61K39/39 , A61K9/0019 , A61K9/0043 , A61K9/107 , A61K38/38 , A61K39/12 , A61K39/145 , A61K47/10 , A61K47/186 , A61K47/26 , A61K47/34 , A61K2039/54 , A61K2039/55566
摘要： The present invention provides compositions comprising emulsion adjuvant and one or more active agents or substances formulated for infusion or injection into a subject (e.g., using a syringe and needle), as well as methods of formulating and using the same (e.g., as an injectable medicinal composition (e.g., a vaccine)). The emulsion adjuvant of an immunogenic composition of the invention in its preferred form comprises a cationic lipid containing a polar head group and a hydrophobic component (e.g., a dual chain hydrophobic group (e.g., the cationic surfactant dioctadecyl dimethyl ammonium chloride (DODAC) and dioctadecyl dimethyl ammonium bromine (DODAB))). Compositions of the invention comprising emulsion adjuvant and one or more active agents or substances formulated for administration via injection to a subject find use in treatment and/or prevention of infectious disease, cancer and/or allergy.
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公开(公告)号：US20170007694A1
公开(公告)日：2017-01-12
申请号：US15203387
申请日：2016-07-06
申请人： NanoBio Corporation
发明人： Susan Ciotti
CPC分类号： A61K9/08 , A61K9/0019 , A61K39/00 , A61K47/18 , A61K47/183 , A61K47/26
摘要： The present disclosure relates to buffer-stabilized protein compositions and methods of making the same. The disclosed compositions and methods provide a means of stabilizing and preserving proteins or peptides in such a way that the proteins or peptides maintain their native conformation and structure, maintain biological activity, and prevent aggregation.
摘要翻译： 本公开涉及缓冲液稳定的蛋白质组合物及其制备方法。 所公开的组合物和方法提供了使蛋白质或肽保持其天然构象和结构，保持生物活性并防止聚集的方式稳定和保存蛋白质或肽的方法。
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公开(公告)号：US20170007689A1
公开(公告)日：2017-01-12
申请号：US15203358
申请日：2016-07-06
申请人： NanoBio Corporation
发明人： Susan Ciotti
CPC分类号： A61K39/07 , A61K9/0043 , A61K9/1075 , A61K2039/543 , A61K2039/55566
摘要： The present disclosure relates to nanoemulsion vaccine compositions and methods of making and using the same. The disclosed compositions and methods provide a means of treating, preventing, or protecting an individual from anthrax exposure or poisoning.
摘要翻译： 本公开涉及纳米乳剂疫苗组合物及其制备和使用方法。 所公开的组合物和方法提供了治疗，预防或保护个体免受炭疽暴露或中毒的手段。
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7.发明申请METHODS AND COMPOSITIONS FOR THE STABILIZATION OF ANTHRAX RECOMBINANT PROTECTIVE ANTIGEN 审中-公开ANTHRAX重组保护性抗原稳定化的方法和组合物公开(公告)号：US20170007690A1
公开(公告)日：2017-01-12
申请号：US15260145
申请日：2016-09-08
申请人： NanoBio Corporation
发明人： Susan Ciotti
CPC分类号： A61K39/07 , A61K9/0019 , A61K9/0043 , A61K9/08 , A61K47/02 , A61K47/18 , A61K47/183 , A61K47/26
摘要： The present disclosure relates to buffer-stabilized anthrax recombinant protective antigen (rPA) compositions and methods of making the same. The disclosed compositions and methods provide a means of stabilizing and preserving rPA in such a way that the protein maintains its native conformation and structure, maintains its immunological activity, and prevents aggregation.
摘要翻译： 本公开涉及缓冲液稳定的炭疽重组保护性抗原（rPA）组合物及其制备方法。 所公开的组合物和方法提供了稳定和保存rPA的方式，使得蛋白质保持其天然构象和结构，保持其免疫活性并防止聚集。
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