公开(公告)号：US20180071380A1

公开(公告)日：2018-03-15

申请号：US15560057

申请日：2016-03-18

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  NANOBIO CORPORATION

发明人： Paul Makidon ,  Vira Bitko ,  Douglas Smith ,  Ali Fattom

IPC分类号： A61K39/02 ,  A61K39/39 ,  A61K47/10

CPC分类号： A61K39/099 ,  A61K9/0043 ,  A61K9/1075 ,  A61K39/39 ,  A61K47/10 ,  A61K47/186 ,  A61K47/26 ,  A61K47/44 ,  A61K2039/543 ,  A61K2039/55566 ,  A61K2039/57

摘要： The present application relates to immunogenic compositions comprising a mixture of Bordetella (e.g., B. pertussis) antigens and an oil in water nanoemulsion. In particular, the invention provides immunogenic compositions comprising nanoemulsion and a combination of Bordetella (e.g., B. pertussis) antigens that have different functions, for example, combinations including B. pertussis adherence factors (adhesins), B. pertussis toxins or B. pertussis virulence factors. Vaccines, methods of treatment, uses of and processes to make a pertussis or whooping cough vaccine are also described. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.

公开(公告)号：US12076397B2

公开(公告)日：2024-09-03

申请号：US16300423

申请日：2017-05-10

申请人： The Regents of the University of Michigan ,  NanoBio Corporation

发明人： James R. Baker, Jr. ,  Douglas M. Smith ,  Susan Ciotti

IPC分类号： A61K39/395 ,  A61K9/00 ,  A61K9/107 ,  A61K38/38 ,  A61K39/12 ,  A61K39/145 ,  A61K39/39 ,  A61K47/10 ,  A61K47/18 ,  A61K47/26 ,  A61K47/34 ,  A61K39/00

CPC分类号： A61K39/39 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/107 ,  A61K38/38 ,  A61K39/12 ,  A61K39/145 ,  A61K47/10 ,  A61K47/186 ,  A61K47/26 ,  A61K47/34 ,  A61K2039/54 ,  A61K2039/55566

摘要： The present invention provides compositions comprising emulsion adjuvant and one or more active agents or substances formulated for infusion or injection into a subject (e.g., using a syringe and needle), as well as methods of formulating and using the same (e.g., as an injectable medicinal composition (e.g., a vaccine)). The emulsion adjuvant of an immunogenic composition of the invention in its preferred form comprises a cationic lipid containing a polar head group and a hydrophobic component (e.g., a dual chain hydrophobic group (e.g., the cationic surfactant dioctadecyl dimethyl ammonium chloride (DODAC) and dioctadecyl dimethyl ammonium bromine (DODAB))). Compositions of the invention comprising emulsion adjuvant and one or more active agents or substances formulated for administration via injection to a subject find use in treatment and/or prevention of infectious disease, cancer and/or allergy.

公开(公告)号：US10596251B2

公开(公告)日：2020-03-24

申请号：US15418626

申请日：2017-01-27

申请人： NanoBio Corporation

发明人： Ali I. Fattom ,  Tarek Hamouda ,  Vira Bitko ,  James R. Baker, Jr.

IPC分类号： A61K39/155 ,  A61K39/12 ,  A61K47/10 ,  A61K47/18 ,  A61K47/26 ,  A61K9/107 ,  A61K47/44 ,  A61K39/00

摘要： The present application relates to the field of immunology, in particular, a vaccine composition of respiratory syncytial virus (RSV) surface proteins, Fusion (F) and Glycoprotein (G) proteins subunit vaccine preferentially mixed with the immune cell targeting and enhancer, nanoemulsion to induce a protective immune response and avoid vaccine-induce disease enhancement.

公开(公告)号：US20170007690A1

公开(公告)日：2017-01-12

申请号：US15260145

申请日：2016-09-08

申请人： NanoBio Corporation

发明人： Susan Ciotti

IPC分类号： A61K39/07 ,  A61K9/08 ,  A61K47/26 ,  A61K47/18 ,  A61K47/02

CPC分类号： A61K39/07 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/08 ,  A61K47/02 ,  A61K47/18 ,  A61K47/183 ,  A61K47/26

摘要： The present disclosure relates to buffer-stabilized anthrax recombinant protective antigen (rPA) compositions and methods of making the same. The disclosed compositions and methods provide a means of stabilizing and preserving rPA in such a way that the protein maintains its native conformation and structure, maintains its immunological activity, and prevents aggregation.

摘要翻译： 本公开涉及缓冲液稳定的炭疽重组保护性抗原（rPA）组合物及其制备方法。 所公开的组合物和方法提供了稳定和保存rPA的方式，使得蛋白质保持其天然构象和结构，保持其免疫活性并防止聚集。

公开(公告)号：US09131680B2

公开(公告)日：2015-09-15

申请号：US14242728

申请日：2014-04-01

申请人： NanoBio Corporation

发明人： Theodore C. Annis ,  James R. Baker ,  Tarek Hamouda

IPC分类号： A01N25/02 ,  A01N25/04 ,  A61K9/107 ,  A61K9/51 ,  A61K9/00 ,  A61K31/7048 ,  C12N7/00 ,  A61K39/00

CPC分类号： A01N25/04 ,  A01N25/02 ,  A61K9/0014 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/0073 ,  A61K9/1075 ,  A61K31/7048 ,  A61K39/00 ,  A61K2039/5252 ,  C12N7/00 ,  C12N2760/16163

摘要： Nanoemulsion compositions with low toxicity that demonstrate broad spectrum inactivation of microorganisms or prevention of diseases are described. The nanoemulsions contain an aqueous phase, an oil phase comprising an oil and an organic solvent, and one or more surfactants. Methods of making nanoemulsions and inactivating pathogenic microorganisms are also provided.

摘要翻译： 描述了显示出微生物的广谱灭活或预防疾病的低毒性的纳米乳剂组合物。 纳米乳剂含有水相，包含油和有机溶剂的油相和一种或多种表面活性剂。 还提供了制备纳米乳剂和灭活病原微生物的方法。

公开(公告)号：US11173207B2

公开(公告)日：2021-11-16

申请号：US16302074

申请日：2017-05-19

申请人： The Regents of the University of Michigan ,  NanoBio Corporation

发明人： James R. Baker, Jr. ,  Douglas M. Smith ,  Susan Ciotti

IPC分类号： A61K39/39 ,  A61P37/04 ,  A61K39/385 ,  A61K39/295 ,  A61K39/00 ,  A61K9/107

摘要： The present invention provides methods and compositions for the stimulation of immune responses. In particular, the invention provides methods and compositions for enhancing an immune response to one or more antigens. Compositions and methods of the invention are useful for the treatment and/or prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites, as well as the treatment and/or prevention of cancer and malignant diseases. Compositions and methods of the invention include one or more antigens/immunogens together with an adjuvant formulation comprising an emulsion delivery system in combination with one or more immunostimulatory compounds (e.g., a compound that stimulates the innate immune system (e.g., a toll-like receptor antagonist (e.g., synthetic oligodeoxynucleotides (ODN)))) that enhance immune responses to the one or more antigens/immunogens when administered to a subject. Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.

公开(公告)号：US20200246449A1

公开(公告)日：2020-08-06

申请号：US16610472

申请日：2018-05-03

申请人： NanoBio Corporation

发明人： Ali I. Fattom ,  Vira Bitko ,  Shyamala GANESAN

IPC分类号： A61K39/12 ,  C07K16/06 ,  C07K16/10 ,  A61P31/14

摘要： The present disclosure relates to intravenous immunoglobulin (WIG) compositions specific for respiratory syncytial virus (RSV) and methods of making and using the same.

公开(公告)号：US20190282693A1

公开(公告)日：2019-09-19

申请号：US16302074

申请日：2017-05-19

申请人： The Regents of the University of Michigan ,  NanoBio Corporation

发明人： James R. Baker, Jr. ,  Douglas M. Smith ,  Susan Ciotti

IPC分类号： A61K39/39 ,  A61K9/107 ,  A61P37/04

摘要： The present invention provides methods and compositions for the stimulation of immune responses. In particular, the invention provides methods and compositions for enhancing an immune response to one or more antigens. Compositions and methods of the invention are useful for the treatment and/or prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites, as well as the treatment and/or prevention of cancer and malignant diseases. Compositions and methods of the invention include one or more antigens/immunogens together with an adjuvant formulation comprising an emulsion delivery system in combination with one or more immunostimulatory compounds (e.g., a compound that stimulates the innate immune system (e.g., a toll-like receptor antagonist (e.g., synthetic oligodeoxynucleotides (ODN)))) that enhance immune responses to the one or more antigens/immunogens when administered to a subject. Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.

公开(公告)号：US20190000761A1

公开(公告)日：2019-01-03

申请号：US15748625

申请日：2016-07-29

申请人： NanoBio Corporation

发明人： Joyce SUTCLIFFE ,  Susan CIOTTI ,  James R. BAKER

IPC分类号： A61K9/107 ,  A61K31/203 ,  A61K31/327 ,  A61K31/60 ,  A61K47/18 ,  A61K47/26 ,  A61K47/44 ,  A61K9/00 ,  A61P17/10

摘要： The present invention relates to methods for treating and preventing acne or P. acnes infection in a subject comprising topically administering to the subject in need thereof an anti-acne nanoemulsion composition, comprising CPC or BKC as a cationic agent.

公开(公告)号：US20170360919A1

公开(公告)日：2017-12-21

申请号：US15418626

申请日：2017-01-27

申请人： NanoBio Corporation

发明人： Ali I. Fattom ,  Tarek Hamouda ,  Vira Bitko ,  James R. Baker, JR.

IPC分类号： A61K39/155 ,  A61K39/12 ,  A61K47/18 ,  A61K47/26 ,  A61K9/107 ,  A61K47/44 ,  A61K47/10 ,  A61K39/00

摘要： The present application relates to the field of immunology, in particular, a vaccine composition of respiratory syncytial virus (RSV) surface proteins, Fusion (F) and Glycoprotein (G) proteins subunit vaccine preferentially mixed with the immune cell targeting and enhancer, nanoemulsion to induce a protective immune response and avoid vaccine-induce disease enhancement.