公开(公告)号：US20220243244A1

公开(公告)日：2022-08-04

申请号：US17716848

申请日：2022-04-08

Applicant: The Scripps Research Institute

Inventor： Floyd E. ROMESBERG ,  Emil C. FISCHER ,  Koji HASHIMOTO ,  Aaron W. FELDMAN ,  Vivian T. DIEN ,  Yorke ZHANG

IPC: C12P21/02

Abstract: Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.

公开(公告)号：US20240043823A1

公开(公告)日：2024-02-08

申请号：US18481086

申请日：2023-10-04

Applicant: Synthorx, Inc. ,  The Scripps Research Institute

Inventor： Jerod PTACIN ,  Carolina CAFFARO ,  Hans AERNI ,  Yorke ZHANG ,  Emil C. FISCHER ,  Aaron W. FELDMAN ,  Vivian T. DIEN ,  Floyd E. ROMESBERG

IPC: C12N9/00 ,  C12P21/02 ,  C12N15/113 ,  C12N15/90

CPC classification number: C12N9/93 ,  C12P21/02 ,  C12Y601/01026 ,  C12N15/113 ,  C12N15/90

Abstract: Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

公开(公告)号：US20210222147A1

公开(公告)日：2021-07-22

申请号：US17196151

申请日：2021-03-09

Applicant: SYNTHORX, INC. ,  THE SCRIPPS RESEARCH INSTITUTE

Inventor： Jerod PTACIN ,  Carolina CAFFARO ,  Hans AERNI ,  Yorke ZHANG ,  Emil C. FISCHER ,  Aaron W. FELDMAN ,  Vivian T. DIEN ,  Floyd E. ROMESBERG

IPC: C12N9/00 ,  C12P21/02 ,  C12N15/113 ,  C12N15/90

Abstract: Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.