公开(公告)号：US20220183994A1

公开(公告)日：2022-06-16

申请号：US17600837

申请日：2020-04-03

Applicant: The Texas A&M University System

Inventor： Carolyn L. Cannon ,  Kush Shah ,  Bhagath Chirra ,  Qingquan Chen ,  Mansoor Khan ,  Hung-Jen Wu

IPC: A61K9/70 ,  A61K33/38 ,  A61K31/197 ,  A61K31/375 ,  A61K31/4045 ,  A61K31/192

Abstract: In an embodiment, a drug delivery system and method of use thereof to treat inflammation and bacterial pathogens including multi-drug resistant pathogens, such as MDR-Pseudomonas aeruginosa, or reactive oxygen species in a subject is provided. In some embodiments, the drug delivery system includes a polymeric material, an excepient, an antioxidant agent, and an anti-inflammatory and antimicrobial agent. In some embodiments, the anti-inflammatory and antimicrobial agent is a salt of an anti-inflammatory agent and an antimicrobial agent formulated to provide a combination of antimicrobial and anti-inflammatory action from a single molecule. In some embodiments, the combined anti-inflammatory and antimicrobial agent is a silver salt of ibuprofen. In other embodiments, the combined anti-inflammatory and antimicrobial agent is unmodified, native ibuprofen.