公开(公告)号：US20240327768A1

公开(公告)日：2024-10-03

申请号：US18574081

申请日：2022-07-07

Applicant: The Texas A&M University System

Inventor： Abhishek Jain ,  James J. Tronolone ,  Biswajit Saha

IPC: C12M3/06 ,  C12M1/12 ,  C12M3/00

CPC classification number: C12M23/16 ,  C12M21/08 ,  C12M25/14

Abstract: In an embodiment, the present disclosure pertains to a medical device. In some embodiments, the medical device includes a first compartmentalized microfluidic channel flanked by two microchannels and a second compartmentalized microfluidic channel. In some embodiments, the first and second compartmentalized microfluidic channels are situated vertically one to another. In some embodiments, the medical device further includes a porous membrane situated between the first and second compartmentalized microfluidic channels. In another embodiment, the present disclosure pertains to an organ-on-chip. In some embodiments, the organ-on-chip includes a top portion having three parallel microchannels. In some embodiments, the three parallel microchannels are separated by micropillars. In some embodiments, the organ-on-chip further includes a bottom portion having a fourth microchannel and a membrane between the top portion and the bottom portion.