-
1.发明申请公开(公告)号：US20210354135A1
公开(公告)日：2021-11-18
申请号：US17319918
申请日：2021-05-13
Applicant: The Texas A&M University System
Inventor： Abhishek Jain , David Jordan Luna
Abstract: A system for evaluating an ability of a blood sample to coagulate, clot, and/or occlude includes a microfluidic device including a body and a tortuous microchannel formed in the body, wherein the tortuous microchannel includes a plurality of alternating curves and has a tortuosity index (TI) of at least 2.0, and a pump fluidically configured to fluidically connect to the tortuous microchannel of the microfluidic device and to induce a blood flow through the tortuous microchannel at at least one of a constant pressure and a constant flowrate.
-
公开(公告)号：US12039885B2
公开(公告)日：2024-07-16
申请号：US16778947
申请日：2020-01-31
Applicant: The Texas A&M University System
Inventor： Abhishek Jain , Navaneeth Krishna Rajeeva Pandian
CPC classification number: G09B23/306 , C12N5/069 , G09B23/303 , G09B23/32
Abstract: A venous valve model includes a first layer having a central axis and a fluid channel extending between a fluid inlet and a fluid outlet formed in the first layer, wherein the fluid channel is defined by a pair of channel walls, a first venous valve formed in the first layer and positioned along the fluid channel, and a pair of first actuation chambers positioned adjacent the channel walls of the fluid channel, wherein the pair of first actuation chambers are configured to decrease a width of the fluid channel in response to pressurization of the pair of first actuation chambers.
-
Patent Agency Ranking
公开(公告)号：US20240331572A1
公开(公告)日：2024-10-03
申请号：US18739567
申请日：2024-06-11
Applicant: The Texas A&M University System
Inventor： Abhishek Jain , Navaneeth Krishna Rajeeva Pandian
CPC classification number: G09B23/306 , C12N5/069 , G09B23/303 , G09B23/32
Abstract: A microfluidic chip for modelling flow through a vein includes a body including a microchannel extending between a fluid inlet and a fluid outlet, wherein at least a portion of the microchannel is coated with endothelial cells that form vascular lumen, and a venous valve formed in the body and positioned along the microchannel, wherein the venous valve includes a pair of leaflets defining a pair of cusps of the venous valve, and a flow channel positioned between the leaflets.
-
公开(公告)号：US20230264191A1
公开(公告)日：2023-08-24
申请号：US18112279
申请日：2023-02-21
Applicant: The Texas A&M University System
Inventor： Abhishek Jain , Amirali Selahi
CPC classification number: B01L3/502707 , B01L3/502761 , C12N5/0602 , B01L3/502715 , B01L2300/0816 , B01L2400/0487 , B01L2300/0864 , B01L2200/025 , B01L2200/10
Abstract: A method for fabricating an in vitro vessel includes forming a substrate that defines a microfluidic passage therein extending along a longitudinal axis and defined by an inner surface, positioning the substrate in a vertical orientation whereby an acute angle is formed between the longitudinal axis of the microfluidic passage and the direction of gravity, and culturing a plurality of first cells in the microfluidic passage while the substrate is disposed in the vertical orientation whereby an annular layer of the plurality of first cells is formed in the microfluidic channel, wherein the layer of the plurality of first cells defines a lumen extending longitudinally through the microfluidic channel.
-
公开(公告)号：US20210394177A1
公开(公告)日：2021-12-23
申请号：US17352135
申请日：2021-06-18
Applicant: The Texas A&M University System
Inventor： Abhishek Jain , Tanmay Mathur , Jonathan Michael Flanagan
Abstract: A system for mimicking a blood vessel of a patient includes a microfluidic device including a body and a microfluidic channel formed in the body, wherein the microfluidic channel includes a fluid inlet and a fluid outlet, and a coating formed on the microfluidic channel including a plurality of blood outgrowth endothelial cells (BOECs) isolated from the patient and which define an inner surface of the microfluidic channel.
-
公开(公告)号：US20200251018A1
公开(公告)日：2020-08-06
申请号：US16778947
申请日：2020-01-31
Applicant: The Texas A&M University System
Inventor： Abhishek Jain , Navaneeth Krishna Rajeeva Pandian
Abstract: A venous valve model includes a first layer having a central axis and a fluid channel extending between a fluid inlet and a fluid outlet formed in the first layer, wherein the fluid channel is defined by a pair of channel walls, a first venous valve formed in the first layer and positioned along the fluid channel, and a pair of first actuation chambers positioned adjacent the channel walls of the fluid channel, wherein the pair of first actuation chambers are configured to decrease a width of the fluid channel in response to pressurization of the pair of first actuation chambers.
-
公开(公告)号：US20240327768A1
公开(公告)日：2024-10-03
申请号：US18574081
申请日：2022-07-07
Applicant: The Texas A&M University System
Inventor： Abhishek Jain , James J. Tronolone , Biswajit Saha
Abstract: In an embodiment, the present disclosure pertains to a medical device. In some embodiments, the medical device includes a first compartmentalized microfluidic channel flanked by two microchannels and a second compartmentalized microfluidic channel. In some embodiments, the first and second compartmentalized microfluidic channels are situated vertically one to another. In some embodiments, the medical device further includes a porous membrane situated between the first and second compartmentalized microfluidic channels. In another embodiment, the present disclosure pertains to an organ-on-chip. In some embodiments, the organ-on-chip includes a top portion having three parallel microchannels. In some embodiments, the three parallel microchannels are separated by micropillars. In some embodiments, the organ-on-chip further includes a bottom portion having a fourth microchannel and a membrane between the top portion and the bottom portion.
-
-
-
-
-
-
Search Results
7
records
(took 0.016 seconds)
