公开(公告)号：US20250144172A1

公开(公告)日：2025-05-08

申请号：US19009000

申请日：2025-01-03

Applicant: The Texas A&M University System

Inventor： Richard H. Gomer ,  Darrell Pilling ,  Nehemiah Cox ,  Tejas R. Karhadkar

IPC: A61K38/17 ,  A61K9/00 ,  A61K31/196 ,  A61K31/215 ,  A61K31/351 ,  A61K31/4192 ,  A61K31/495 ,  A61P11/00 ,  A61P19/04 ,  C07K16/40

Abstract: The present disclosure relates to anti-fibrotic sialidase-inhibitor compounds and methods of preventing or inhibiting fibrosis using such compounds. The present disclosure also relates to methods of controlling the formation of fibrocytes or their activity using such compounds. The compounds may include both antibodies as well as small molecules. The methods may involve administering the compounds to a patient with or at risk of developing fibrosis in a manner that inhibits at least one sialidase in the patient.

公开(公告)号：US20190201485A1

公开(公告)日：2019-07-04

申请号：US16293379

申请日：2019-03-05

Applicant: The Texas A&M University System

Inventor： Richard H. Gomer ,  Darrell Pilling ,  Nehemiah Cox ,  Tejas R. Karhadkar

IPC: A61K38/17 ,  A61K9/00 ,  A61K31/351 ,  A61P19/04 ,  A61K31/4192 ,  A61K31/495

CPC classification number: A61K38/177 ,  A61K9/0019 ,  A61K31/196 ,  A61K31/215 ,  A61K31/351 ,  A61K31/4192 ,  A61K31/495 ,  A61P11/00 ,  A61P19/04 ,  C07K16/40 ,  Y02A50/401

Abstract: The present disclosure relates to anti-fibrotic sialidase-inhibitor compounds and methods of preventing or inhibiting fibrosis using such compounds. The present disclosure also relates to methods of controlling the formation of fibrocytes or their activity using such compounds. The compounds may include both antibodies as well as small molecules. The methods may involve administering the compounds to a patient with or at risk of developing fibrosis in a manner that inhibits at least one sialidase in the patient.