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公开(公告)号：US12153045B2
公开(公告)日：2024-11-26
申请号：US17324851
申请日：2021-05-19
Applicant: The Texas A&M University System
Inventor： Pao Tai Lin
IPC: G01N33/543 , G01N33/569 , G02B6/10
Abstract: A photonic biosensor including a biological probe disposed on a mid-infrared-transparent waveguide can be used to detect biological analytes in biological samples, using specific binding of the analyte to the probe in conjunction with absorption spectroscopy. In various embodiments, the biosensor is used for molecular diagnostics, e.g., to detect oligonucleotides or proteins associated with a coronavirus.
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公开(公告)号：US10725239B2
公开(公告)日：2020-07-28
申请号：US16179470
申请日：2018-11-02
Applicant: The Texas A&M University System
Inventor： Pao Tai Lin
Abstract: A waveguide structure including a mid-infrared-transparent waveguide on a mid-infrared-transparent undercladding may serve as a photonic chemical sensor for measuring characteristic absorptions of analytes brought in physical contact with the waveguide. In some embodiments, a sensor including an amorphous-silicon waveguide on a barium-titanate undercladding can operate at wavelengths ranging from 2.5 μm to about 7 μm; this sensor may be manufactured by epitaxial growth of the undercladding on a substrate, followed by CMOS-compatible creation of the waveguide. Additional embodiments are disclosed.
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公开(公告)号：US20210364442A1
公开(公告)日：2021-11-25
申请号：US17325109
申请日：2021-05-19
Applicant: The Texas A&M University System
Inventor： Pao Tai Lin
Abstract: Raman spectroscopy of chemical and biological samples can be accomplished with photonic sensors amenable to chip-scale integration. In various embodiments, such a photonic sensor includes first and second optical waveguides coupled via an optical ring resonator, the ring resonator configured to resonantly enhance, and selectively couple into the second optical waveguide, a Raman scattering signal generated, when the first waveguide and/or resonator are exposed to a sample, by interaction of an analyte in the sample with excitation light coupled into the first optical waveguide.
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公开(公告)号：US10591410B2
公开(公告)日：2020-03-17
申请号：US16179502
申请日：2018-11-02
Applicant: The Texas A&M University System
Inventor： Pao Tai Lin
IPC: G01N21/35 , G01N21/25 , G02B6/10 , G01N21/3577 , G01N21/3504 , G01N21/77
Abstract: A flexible waveguide structure including a waveguide on a flexible substrate, both having transparent windows in the mid-infrared range, may serve as a photonic chemical sensor for measuring characteristic absorptions of analytes brought in physical contact with the waveguide. Such a sensor may, in accordance with some embodiments, be formed by an aluminum-nitride waveguide on a borosilicate substrate.
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Patent Agency Ranking
公开(公告)号：US20250044226A1
公开(公告)日：2025-02-06
申请号：US18927314
申请日：2024-10-25
Applicant: The Texas A&M University System
Inventor： Pao Tai Lin
Abstract: Chalcogenide waveguides with high width-to-height aspect ratios and a smooth exposed surfaces can serve as mid-infrared evanescent-absorption-based sensors for detecting and identifying volatile organic compounds and/or determining their concentration, optionally in real-time. The waveguide sensors may be manufactured using a modified sputtering process in which the sputtering target and waveguide substrate are titled and/or laterally offset relative to each other and the substrate is continuously rotated.
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公开(公告)号：US12152986B2
公开(公告)日：2024-11-26
申请号：US18089872
申请日：2022-12-28
Applicant: The Texas A&M University System
Inventor： Pao Tai Lin
Abstract: Chalcogenide waveguides with high width-to-height aspect ratios and a smooth exposed surfaces can serve as mid-infrared evanescent-absorption-based sensors for detecting and identifying volatile organic compounds and/or determining their concentration, optionally in real-time. The waveguide sensors may be manufactured using a modified sputtering process in which the sputtering target and waveguide substrate are titled and/or laterally offset relative to each other and the substrate is continuously rotated.
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公开(公告)号：US20230140255A1
公开(公告)日：2023-05-04
申请号：US18089872
申请日：2022-12-28
Applicant: The Texas A&M University System
Inventor： Pao Tai Lin
Abstract: Chalcogenide waveguides with high width-to-height aspect ratios and a smooth exposed surfaces can serve as mid-infrared evanescent-absorption-based sensors for detecting and identifying volatile organic compounds and/or determining their concentration, optionally in real-time. The waveguide sensors may be manufactured using a modified sputtering process in which the sputtering target and waveguide substrate are titled and/or laterally offset relative to each other and the substrate is continuously rotated.
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公开(公告)号：US11561172B2
公开(公告)日：2023-01-24
申请号：US16589818
申请日：2019-10-01
Applicant: The Texas A&M University System
Inventor： Pao Tai Lin
Abstract: Chalcogenide waveguides with high width-to-height aspect ratios and a smooth exposed surfaces can serve as mid-infrared evanescent-absorption-based sensors for detecting and identifying volatile organic compounds and/or determining their concentration, optionally in real-time. The waveguide sensors may be manufactured using a modified sputtering process in which the sputtering target and waveguide substrate are titled and/or laterally offset relative to each other and the substrate is continuously rotated.
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公开(公告)号：US20210364510A1
公开(公告)日：2021-11-25
申请号：US17324851
申请日：2021-05-19
Applicant: The Texas A&M University System
Inventor： Pao Tai Lin
IPC: G01N33/543 , G02B6/10 , G01N33/569
Abstract: A photonic biosensor including a biological probe disposed on a mid-infrared-transparent waveguide can be used to detect biological analytes in biological samples, using specific binding of the analyte to the probe in conjunction with absorption spectroscopy. In various embodiments, the biosensor is used for molecular diagnostics, e.g., to detect oligonucleotides or proteins associated with a coronavirus.
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