公开(公告)号：US20220152226A1

公开(公告)日：2022-05-19

申请号：US17437417

申请日：2020-03-27

Applicant: The Texas A&M University System

Inventor： Lin Zhu ,  Yin Liu ,  Ying Tu

IPC: A61K49/00 ,  A61K47/69 ,  C08G65/337 ,  C08G18/28 ,  C08G18/71

Abstract: In an embodiment, the present disclosure relates to a targeting platform that includes a targeted delivery system including an agent. In some embodiments, the targeted delivery system is modified by fluorination. In some embodiments, the targeted delivery system is electrically charge neutral. In a further embodiment, the present disclosure relates to a method that includes fluorinating a targeting compound with a fluorinating reagent and loading an agent with the fluorinated targeting compound to thereby form a micelle. In an additional embodiment, the present disclosure relates to a targeting platform that includes a fluorinated polymeric system including an agent. In another embodiment, the present disclosure relates to a method that includes fluorinating a targeting compound with a fluorinating reagent and loading an agent with the fluorinated targeting compound to thereby form a micelle. Additionally, the method can include administering the fluorinated targeting compound to a subject.