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公开(公告)号：US20210259984A1
公开(公告)日：2021-08-26
申请号：US17260640
申请日：2019-07-19
IPC分类号： A61K9/51 , C08G63/08 , C08G63/664 , C08G73/10 , C08G81/00
摘要： Hydrophilic molecules such as biologics, which can include peptides, proteins, and other biologically-derived materials, can be used as therapeutic agents in medical applications. They can face administration challenges because of poor membrane permeability and rapid clearance from the blood stream. Methods for the formation of a core-shell-brush nanoparticle from an A-B-C triblock copolymer are set forth. A hydrophilic core can contain the biologic and the C Block of the copolymer. The shell can be comprised of the precipitated B Block, and the A Block can form a stabilizing brush layer. The particles can be assembled by sequential precipitations under defined mixing conditions. Presented herein are methods to tune release based on process parameters during particle assembly and triblock characteristics.
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公开(公告)号：US20190008788A1
公开(公告)日：2019-01-10
申请号：US16064935
申请日：2016-12-21
IPC分类号： A61K9/50
摘要： An “inverse” precipitation route to precipitate aqueous soluble species with copolymers as nanoparticles having a hydrophilic, polar core and a less polar shell is described. The aggregation of these nanoparticles to form larger microparticles and monoliths provides a highly loaded construct (e.g., a depot) for the sustained and controlled release of actives.
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