公开(公告)号：US20240408050A1

公开(公告)日：2024-12-12

申请号：US18812747

申请日：2024-08-22

Applicant: The Trustees of Princeton University ,  Cheers Health, Inc.

Inventor： Robert K. PRUD'HOMME ,  Brooks POWELL ,  Vikram PANSARE ,  Nicholas CAGGIANO ,  Jie FENG

IPC: A61K31/352 ,  A61K9/16 ,  A61K9/19 ,  A61K45/06

Abstract: Compositions including dihydromyricetin (DHM) and methods for forming them through spray drying.

公开(公告)号：US20200268679A1

公开(公告)日：2020-08-27

申请号：US16761140

申请日：2018-11-02

Applicant: The Trustees of Princeton University

Inventor： Robert K. PRUD'HOMME ,  Kurt D. RISTROPH ,  Nathalie M. PINKERTON ,  Hoang D. LU ,  Paradorn RUMMANEETHORN

IPC: A61K9/51 ,  A61K31/7036 ,  A61K38/12 ,  A61K38/10 ,  A61K31/5377 ,  A61K38/38 ,  A61K38/47

Abstract: Methods for encapsulating water-soluble biologic and small molecule active pharmaceutical ingredients (APIs) into nanoparticles by applying nanoprecipitation techniques and ion-pairing the nanoparticles with hydrophobic counterions to produce new API salts that exhibit altered solubilities are presented.

公开(公告)号：US20180199436A1

公开(公告)日：2018-07-12

申请号：US15911623

申请日：2018-03-05

Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY ,  VORBECK MATERIALS CORPORATION

Inventor： John M. CRAIN ,  John S. LETTOW ,  Ilhan A. AKSAY ,  Sibel KORKUT ,  Katherine S. CHIANG ,  Chuan-Hua CHEN ,  Robert K. PRUD'HOMME

IPC: H05K1/09 ,  C09D11/037 ,  C09D7/65 ,  C09C1/46

CPC classification number: H05K1/095 ,  B82Y30/00 ,  B82Y40/00 ,  C01P2004/02 ,  C01P2006/12 ,  C01P2006/40 ,  C08K3/04 ,  C09C1/46 ,  C09D7/65 ,  C09D7/70 ,  C09D11/037 ,  C09D11/102 ,  C09D11/52 ,  C09D171/02 ,  C09D177/00 ,  H01L2924/0002 ,  H05K1/092 ,  H05K3/0091 ,  H05K3/12 ,  H05K2201/0323 ,  Y10S977/734 ,  Y10S977/847 ,  Y10S977/932 ,  H01L2924/00

Abstract: Printed electronic device comprising a substrate onto at least one surface of which has been applied a layer of an electrically conductive ink comprising functionalized graphene sheets and at least one binder. A method of preparing printed electronic devices is further disclosed.

公开(公告)号：US20230210812A1

公开(公告)日：2023-07-06

申请号：US17899157

申请日：2022-08-30

Applicant: The Trustees of Princeton University ,  Cheers Health, Inc.

Inventor： Robert K. PRUD'HOMME ,  Brooks POWELL ,  Chang TIAN

IPC: A61K9/51 ,  A61K31/352 ,  A61K33/26 ,  A61K33/34 ,  A61K33/06

CPC classification number: A61K9/5161 ,  A61K31/352 ,  A61K9/5146 ,  A61K33/26 ,  A61K33/34 ,  A61K33/06 ,  B82Y5/00

Abstract: Compositions that increase the bioavailability of dihydromyricetin are presented. The bioavailability is increased by methods including formulating dihydromyricetin in nanoparticle form, delivering dihydromyricetin with permeabilizers, and encapsulating dihydromyricetin with an enteric coating.

公开(公告)号：US20230126007A1

公开(公告)日：2023-04-27

申请号：US18083458

申请日：2022-12-16

Applicant: The Trustees of Princeton University

Inventor： Robert F. PAGELS ,  Robert K. PRUD'HOMME

IPC: A61K9/51 ,  A61K31/00 ,  A61K31/405 ,  A61K31/7036 ,  A61K38/06 ,  A61K38/14 ,  A61K38/47 ,  C09B67/02

Abstract: An “inverse” precipitation route to precipitate aqueous soluble species with copolymers as nanoparticles having a hydrophilic, polar core and a less polar shell is described.

公开(公告)号：US20180221509A1

公开(公告)日：2018-08-09

申请号：US15885591

申请日：2018-01-31

Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY ,  CELATOR PHARMACEUTICALS, INC.

Inventor： Lawrence D. MAYER ,  Robert K. PRUD'HOMME ,  Christine J. ALLEN ,  Walid S. SAAD

IPC: A61K47/69 ,  B82Y5/00 ,  A61Q17/04 ,  A61K8/85 ,  A61K47/22 ,  A61K45/06 ,  A61K9/51 ,  A61K47/54 ,  A61K47/59 ,  A61K47/55

CPC classification number: A61K47/6931 ,  A61K8/85 ,  A61K9/5153 ,  A61K45/06 ,  A61K47/22 ,  A61K47/54 ,  A61K47/543 ,  A61K47/545 ,  A61K47/55 ,  A61K47/551 ,  A61K47/552 ,  A61K47/58 ,  A61K47/59 ,  A61K47/593 ,  A61K47/60 ,  A61K47/6935 ,  A61K2800/57 ,  A61Q17/04 ,  B82Y5/00

Abstract: Particulate constructs stabilized by amphiphilic copolymers and comprising at least one active coupled to a hydrophobic moiety provide sustained release of the active in both in vitro and in vivo environments.

公开(公告)号：US20170318672A1

公开(公告)日：2017-11-02

申请号：US15459973

申请日：2017-03-15

Applicant: The Trustees of Princeton University

Inventor： Robert K. PRUD'HOMME ,  Ilhan A. Aksay

IPC: H05K1/09 ,  H05K3/10 ,  B82Y40/00 ,  H05K3/00 ,  H01G4/20 ,  B82Y30/00

CPC classification number: H05K1/095 ,  B82Y30/00 ,  B82Y40/00 ,  C01B31/0423 ,  C01B31/043 ,  C01B31/0476 ,  C01B32/192 ,  C01B32/225 ,  C01B32/23 ,  C01B2204/32 ,  H01G4/206 ,  H05K3/0091 ,  H05K3/10 ,  H05K2201/0323 ,  Y02E60/324 ,  Y02E60/325 ,  Y02E60/328 ,  Y10T428/13 ,  Y10T428/1341 ,  Y10T428/1379 ,  Y10T428/2982

Abstract: A thermal overload device containing a polymer composite, which contains at least one polymer and a modified graphite oxide material, containing thermally exfoliated graphite oxide having a surface area of from about 300 m2/g to 2600 m2/g, and a method of making the same.

公开(公告)号：US20170073504A1

公开(公告)日：2017-03-16

申请号：US15362914

申请日：2016-11-29

Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY

Inventor： Ilhan A. AKSAY ,  David L. MILIUS ,  Sibel KORKUT ,  Robert K. PRUD'HOMME

IPC: C08K9/00 ,  C09D7/12 ,  H01B1/04 ,  C08L71/12 ,  C08L27/18 ,  H01B1/24 ,  C08K3/04 ,  C08L77/06

CPC classification number: C08K9/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/192 ,  C01B32/194 ,  C01B2204/22 ,  C01B2204/30 ,  C01B2204/32 ,  C01P2002/70 ,  C01P2006/10 ,  C01P2006/12 ,  C01P2006/40 ,  C01P2006/80 ,  C08K3/04 ,  C08K3/042 ,  C08K2201/001 ,  C08K2201/006 ,  C08L27/18 ,  C08L71/123 ,  C08L77/06 ,  C09D7/62 ,  H01B1/04 ,  H01B1/24

Abstract: Functionalized graphene sheets having a carbon to oxygen molar ratio of at least about 23:1 and method of preparing the same.

Abstract translation: 具有至少约23:1的碳与氧摩尔比的官能化石墨烯片及其制备方法。

公开(公告)号：US20170034912A1

公开(公告)日：2017-02-02

申请号：US15295492

申请日：2016-10-17

Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY ,  VORBECK MATERIALS CORPORATION

Inventor： John M. CRAIN ,  John S. LETTOW ,  llhan A. AKSAY ,  Sibel KORKUT ,  Katherine S. CHIANG ,  Chuan-Hua CHEN ,  Robert K. PRUD'HOMME

IPC: H05K1/09 ,  C09D11/52 ,  C09D177/00 ,  C09D11/037 ,  C09C1/46 ,  C09D171/02 ,  H05K3/12 ,  C09D11/102

CPC classification number: H05K1/095 ,  B82Y30/00 ,  B82Y40/00 ,  C01P2004/02 ,  C01P2006/12 ,  C01P2006/40 ,  C08K3/04 ,  C09C1/46 ,  C09D7/65 ,  C09D7/70 ,  C09D11/037 ,  C09D11/102 ,  C09D11/52 ,  C09D171/02 ,  C09D177/00 ,  H01L2924/0002 ,  H05K1/092 ,  H05K3/0091 ,  H05K3/12 ,  H05K2201/0323 ,  Y10S977/734 ,  Y10S977/847 ,  Y10S977/932 ,  H01L2924/00

Abstract: Printed electronic device comprising a substrate onto at least one surface of which has been applied a layer of an electrically conductive ink comprising functionalized graphene sheets and at least one binder. A method of preparing printed electronic devices is further disclosed.

Abstract translation: 印刷电子器件包括至少一个表面上的衬底，该衬底已经涂覆了包含官能化石墨烯片和至少一种粘合剂的导电油墨层。 进一步公开了制备印刷电子器件的方法。

公开(公告)号：US20230285352A1

公开(公告)日：2023-09-14

申请号：US17943691

申请日：2022-09-13

Applicant: The Trustees of Princeton University ,  Cheers Health, Inc.

Inventor： Robert K. PRUD'HOMME ,  Brooks POWELL ,  Vikram PANSARE ,  Nicholas CAGGIANO

IPC: A61K31/352 ,  A61K9/16 ,  A61K9/10 ,  A61K9/28 ,  A61K9/06 ,  A61K45/06

CPC classification number: A61K31/352 ,  A61K9/06 ,  A61K9/10 ,  A61K9/1617 ,  A61K9/1647 ,  A61K9/2846 ,  A61K45/06

Abstract: Compositions including dihydromyricetin (DHM) and methods for forming them through hot melt extrusion.