公开(公告)号：US20220378941A1

公开(公告)日：2022-12-01

申请号：US17426389

申请日：2020-02-05

Applicant: The Trustees of Princeton University

Inventor： Esteban Engel ,  Carola Maturana ,  Lynn Enquist

IPC: A61K48/00 ,  C12N15/86 ,  C07K14/005

Abstract: Provided are recombinant nucleic acids (e.g., vectors), and related methods, for expression of a target gene in a host cell. The recombinant nucleic acids comprise a promoter comprising a nucleic acid sequence having at least 70% sequence identity to a sequence selected from SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8 and SEQ ID NO: 9; a cloning site for insertion of a nucleic acid encoding the target gene; and at least one non-promoter regulatory element required for the expression of the target gene in the host cell.