公开(公告)号：US20200268679A1

公开(公告)日：2020-08-27

申请号：US16761140

申请日：2018-11-02

Applicant: The Trustees of Princeton University

Inventor： Robert K. PRUD'HOMME ,  Kurt D. RISTROPH ,  Nathalie M. PINKERTON ,  Hoang D. LU ,  Paradorn RUMMANEETHORN

IPC: A61K9/51 ,  A61K31/7036 ,  A61K38/12 ,  A61K38/10 ,  A61K31/5377 ,  A61K38/38 ,  A61K38/47

Abstract: Methods for encapsulating water-soluble biologic and small molecule active pharmaceutical ingredients (APIs) into nanoparticles by applying nanoprecipitation techniques and ion-pairing the nanoparticles with hydrophobic counterions to produce new API salts that exhibit altered solubilities are presented.