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公开(公告)号：US11230590B2
公开(公告)日：2022-01-25
申请号：US16574954
申请日：2019-09-18
申请人： The United States of America, as Represented by the Secretary of Agriculture , Arkion Life Sciences, LLC
发明人： Hyun S. Lillehoj , Earnest W. Porta , Samuel V. Walker , Leslie A. Confer , Ujvala Deepthi Gadde , Cyril Gay
IPC分类号： A61K39/40 , C07K16/02 , C07K16/12 , C07K16/20 , A61K9/00 , A61K47/46 , A23K10/20 , A23K10/18 , A61P31/04 , A61P29/00 , A23K50/75 , A61K39/00
摘要： In one aspect, the present invention is directed to a method for preventing or treating necrotic enteritis by administering a hyperimmunized egg product obtained from an egg-producing animal to an avian. The hyperimmunized egg product may contain an antibody specific to an antigen selected from the group consisting of Clostridium perfringens α-toxin, Clostridium perfringens elongation factor Tu (EF-Tu), Clostridium perfringens necrotic enteritis B-like (NetB) toxin, Clostridium perfringens Pyruvate: Ferredoxin oxidoreductase (PFO), and Eimeria tenella elongation factor 1-alpha.
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公开(公告)号：US20200002404A1
公开(公告)日：2020-01-02
申请号：US16574954
申请日：2019-09-18
申请人： The United States of America, as Represented by the Secretary of Agriculture , Arkion Life Sciences, LLC
发明人： Hyun S. Lillehoj , Earnest W. Porta , Samuel V. Walker , Leslie A. Confer , Ujvala Deepthi Gadde , Cyril Gay
IPC分类号： C07K16/02 , C07K16/12 , C07K16/20 , A61K9/00 , A61K47/46 , A23K10/20 , A23K10/18 , A61P31/04 , A61P29/00 , A23K50/75
摘要： In one aspect, the present invention is directed to a method for preventing or treating necrotic enteritis by administering a hyperimmunized egg product obtained from an egg-producing animal to an avian. The hyperimmunized egg product may contain an antibody specific to an antigen selected from the group consisting of Clostridium perfringens α-toxin, Clostridium perfringens elongation factor Tu (EF-Tu), Clostridium perfringens necrotic enteritis B-like (NetB) toxin, Clostridium perfringens Pyruvate: Ferredoxin oxidoreductase (PFO), and Eimeria tenella elongation factor 1-alpha.
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3.发明公开公开(公告)号：US20240102027A1
公开(公告)日：2024-03-28
申请号：US18376543
申请日：2023-10-04
发明人： Jolieke G. Van Oosterwijk , Luciana Meirelles Richer , Douglas Steven Zetechka, JR. , Hyun Soon Lillehoj , Woohyun Kim , Cyril Gay , Christopher Anthony Przybyszewski
IPC分类号： C12N15/75 , A61K9/00 , A61K35/742 , C07K14/465
CPC分类号： C12N15/75 , A61K9/0053 , A61K35/742 , C07K14/465
摘要： The inventive subject matter includes an antimicrobial peptide vectored composition made of a bacterial protein expression vehicle expressing one or more recombinant antimicrobial peptide effector molecules. More specifically these novel recombinant antimicrobial peptide effector molecules exhibit preferential antimicrobial activity. In some embodiments, the antimicrobial activity is facilitated via interaction with the lipid bilayer of the parasitic cell form, leading to membrane pore formation and resulting in cell lysis. The utility of the current inventive subject matter has demonstrated a reduced viability of Eimeira acervulina sporozoites was shown in vitro using a sporozoite killing assay. More specifically, the antimicrobial peptide vectored composition is a bacterial protein expression vehicle expressing one or more recombinant antimicrobial peptide effector molecules, wherein the one or more recombinant antimicrobial peptide effector molecules are engineered from a NK-lysin gene and the one or more recombinant antimicrobial peptide effector molecules are engineered to express functionally active NK-2. More specifically, the one or more recombinant antimicrobial peptide effector molecules induce cytotoxicity against infectious agents of the phylum of Apicomplexa.
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公开(公告)号：US20180230199A1
公开(公告)日：2018-08-16
申请号：US15895636
申请日：2018-02-13
申请人： United States of America, as Represented by the Secretary of Agriculture , Arkion Life Sciences, LLC
发明人： Hyun S. Lillehoh , Earnest W. Porta , Samuel V. Walker , Leslie A. Confer , Ujvala Deepthi Gadde , Cyril Gay
IPC分类号： C07K16/02 , C07K16/12 , C07K16/20 , A61K9/00 , A61K47/46 , A23K50/75 , A23K10/20 , A23K10/18 , A61P31/04 , A61P29/00
摘要： In one aspect, the present invention is directed to a method for preventing or treating necrotic enteritis by administering a hyperimmunized egg product obtained from an egg-producing animal to an avian. The hyperimmunized egg product may contain an antibody specific to an antigen selected from the group consisting of Clostridium perfringens α-toxin, Clostridium perfringens elongation factor Tu (EF-Tu), Clostridium perfringens necrotic enteritis B-like (NetB) toxin, Clostridium perfringens Pyruvate: Ferredoxin oxidoreductase (PFO), and Eimeria tenella elongation factor 1-alpha.
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公开(公告)号：US10450364B2
公开(公告)日：2019-10-22
申请号：US15895636
申请日：2018-02-13
申请人： United States of America, as Represented by the Secretary of Agriculture , Arkion Life Sciences, LLC
发明人： Hyun S. Lillehoj , Earnest W. Porta , Samuel V. Walker , Leslie A. Confer , Ujvala Deepthi Gadde , Cyril Gay
IPC分类号： A61K39/40 , C07K16/02 , C07K16/12 , C07K16/20 , A61K9/00 , A61K47/46 , A23K10/20 , A23K10/18 , A61P31/04 , A61P29/00 , A23K50/75 , A61K39/00
摘要： In one aspect, the present invention is directed to a method for preventing or treating necrotic enteritis by administering a hyperimmunized egg product obtained from an egg-producing animal to an avian. The hyperimmunized egg product may contain an antibody specific to an antigen selected from the group consisting of Clostridium perfringens α-toxin, Clostridium perfringens elongation factor Tu (EF-Tu), Clostridium perfringens necrotic enteritis B-like (NetB) toxin, Clostridium perfringens Pyruvate: Ferredoxin oxidoreductase (PFO), and Eimeria tenella elongation factor 1-alpha.
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