公开(公告)号：US20180230199A1

公开(公告)日：2018-08-16

申请号：US15895636

申请日：2018-02-13

申请人： United States of America, as Represented by the Secretary of Agriculture ,  Arkion Life Sciences, LLC

发明人： Hyun S. Lillehoh ,  Earnest W. Porta ,  Samuel V. Walker ,  Leslie A. Confer ,  Ujvala Deepthi Gadde ,  Cyril Gay

IPC分类号： C07K16/02 ,  C07K16/12 ,  C07K16/20 ,  A61K9/00 ,  A61K47/46 ,  A23K50/75 ,  A23K10/20 ,  A23K10/18 ,  A61P31/04 ,  A61P29/00

摘要： In one aspect, the present invention is directed to a method for preventing or treating necrotic enteritis by administering a hyperimmunized egg product obtained from an egg-producing animal to an avian. The hyperimmunized egg product may contain an antibody specific to an antigen selected from the group consisting of Clostridium perfringens α-toxin, Clostridium perfringens elongation factor Tu (EF-Tu), Clostridium perfringens necrotic enteritis B-like (NetB) toxin, Clostridium perfringens Pyruvate: Ferredoxin oxidoreductase (PFO), and Eimeria tenella elongation factor 1-alpha.

公开(公告)号：US11230590B2

公开(公告)日：2022-01-25

申请号：US16574954

申请日：2019-09-18

申请人： The United States of America, as Represented by the Secretary of Agriculture ,  Arkion Life Sciences, LLC

发明人： Hyun S. Lillehoj ,  Earnest W. Porta ,  Samuel V. Walker ,  Leslie A. Confer ,  Ujvala Deepthi Gadde ,  Cyril Gay

IPC分类号： A61K39/40 ,  C07K16/02 ,  C07K16/12 ,  C07K16/20 ,  A61K9/00 ,  A61K47/46 ,  A23K10/20 ,  A23K10/18 ,  A61P31/04 ,  A61P29/00 ,  A23K50/75 ,  A61K39/00

摘要： In one aspect, the present invention is directed to a method for preventing or treating necrotic enteritis by administering a hyperimmunized egg product obtained from an egg-producing animal to an avian. The hyperimmunized egg product may contain an antibody specific to an antigen selected from the group consisting of Clostridium perfringens α-toxin, Clostridium perfringens elongation factor Tu (EF-Tu), Clostridium perfringens necrotic enteritis B-like (NetB) toxin, Clostridium perfringens Pyruvate: Ferredoxin oxidoreductase (PFO), and Eimeria tenella elongation factor 1-alpha.

公开(公告)号：US20200002404A1

公开(公告)日：2020-01-02

申请号：US16574954

申请日：2019-09-18

申请人： The United States of America, as Represented by the Secretary of Agriculture ,  Arkion Life Sciences, LLC

发明人： Hyun S. Lillehoj ,  Earnest W. Porta ,  Samuel V. Walker ,  Leslie A. Confer ,  Ujvala Deepthi Gadde ,  Cyril Gay

IPC分类号： C07K16/02 ,  C07K16/12 ,  C07K16/20 ,  A61K9/00 ,  A61K47/46 ,  A23K10/20 ,  A23K10/18 ,  A61P31/04 ,  A61P29/00 ,  A23K50/75

摘要： In one aspect, the present invention is directed to a method for preventing or treating necrotic enteritis by administering a hyperimmunized egg product obtained from an egg-producing animal to an avian. The hyperimmunized egg product may contain an antibody specific to an antigen selected from the group consisting of Clostridium perfringens α-toxin, Clostridium perfringens elongation factor Tu (EF-Tu), Clostridium perfringens necrotic enteritis B-like (NetB) toxin, Clostridium perfringens Pyruvate: Ferredoxin oxidoreductase (PFO), and Eimeria tenella elongation factor 1-alpha.

公开(公告)号：US10450364B2

公开(公告)日：2019-10-22

申请号：US15895636

申请日：2018-02-13

申请人： United States of America, as Represented by the Secretary of Agriculture ,  Arkion Life Sciences, LLC

发明人： Hyun S. Lillehoj ,  Earnest W. Porta ,  Samuel V. Walker ,  Leslie A. Confer ,  Ujvala Deepthi Gadde ,  Cyril Gay

IPC分类号： A61K39/40 ,  C07K16/02 ,  C07K16/12 ,  C07K16/20 ,  A61K9/00 ,  A61K47/46 ,  A23K10/20 ,  A23K10/18 ,  A61P31/04 ,  A61P29/00 ,  A23K50/75 ,  A61K39/00

摘要： In one aspect, the present invention is directed to a method for preventing or treating necrotic enteritis by administering a hyperimmunized egg product obtained from an egg-producing animal to an avian. The hyperimmunized egg product may contain an antibody specific to an antigen selected from the group consisting of Clostridium perfringens α-toxin, Clostridium perfringens elongation factor Tu (EF-Tu), Clostridium perfringens necrotic enteritis B-like (NetB) toxin, Clostridium perfringens Pyruvate: Ferredoxin oxidoreductase (PFO), and Eimeria tenella elongation factor 1-alpha.

公开(公告)号：US20220354147A1

公开(公告)日：2022-11-10

申请号：US17738583

申请日：2022-05-06

申请人： Arkion Life Sciences, LLC

发明人： Shawn Jones ,  Emily Hudson ,  Earnest W. Porta ,  Samuel V. Walker

IPC分类号： A23K10/20 ,  A23K40/10 ,  A23K20/163

摘要： The present disclosure is directed to methods of producing egg granules comprising spray drying an egg comprising one or more antibodies to produce a low moisture egg powder; and dry granulating the low moisture egg powder to produce egg granules comprising the one or more antibodies. The present disclosure also relates to egg granule having a diameter in a range of about 0.70 mm to about 5.00 mm, wherein the egg granule comprises one or more antibodies.