专利检索 ap:("The United States of America, as represented by the Secretary, Department of Health AND Human Serv" OR "The Chancellor, Masters AND Scholars of the University of Oxford") AND inv:"Leonard SEYMOUR" 第 1 页

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发明申请
EXPRESSION VECTOR DELIVERY SYSTEM AND USE THEREOF FOR INDUCING AN IMMUNE RESPONSE 审中-公开

公开(公告)号：US20180280497A1

公开(公告)日：2018-10-04

申请号：US15758505

申请日：2016-09-09

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv , The Chancellor, Masters and Scholars of the University of Oxford

发明人： Robert SEDER , Geoffrey LYNN , Leonard SEYMOUR

IPC分类号： A61K39/39 , A61K47/64 , A61K48/00 , A61K47/59 , A61K47/65

CPC分类号： A61K39/39 , A61K47/59 , A61K47/6455 , A61K47/65 , A61K48/0041 , A61K2039/53 , A61K2039/55511 , A61K2039/55555 , A61K2039/6093

摘要： Embodiments of a novel system for delivering an expression vector encoding an antigen to a subject that allows for spatiotemporal control over stimulation of the subject's immune response to the antigen are provided. In some embodiments, the expression vector delivery system includes a polymer linked to an adjuvant in prodrug form that can form polymer nanoparticles and enter a cell (such as an immune cell) under physiological conditions. In some embodiments, the adjuvant is linked to the polymer by an enzyme degradable labile bond, the cleavage of which activates the adjuvant to stimulate an immune response.