公开(公告)号：US20230381293A1

公开(公告)日：2023-11-30

申请号：US18031602

申请日：2021-10-14

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv ,  The University of North Carolina at Chapel Hill ,  Board of Regents, the University of Texas System

发明人： Peter Kwong ,  Raffaello Verardi ,  Yaroslav Tsybovsky ,  Jason Gorman ,  Gwo-Yu Chuang ,  Li Ou ,  Lisa Lindesmith ,  Ralph Baric ,  George Georgiou ,  Inga Rimkute ,  Mario Roederer

IPC分类号： A61K39/145 ,  A61P37/04 ,  G01N33/68

CPC分类号： A61K39/145 ,  A61P37/04 ,  G01N33/6854 ,  A61K2039/5258

摘要： Recombinant Norovirus Virus-Like Particles (VLPs) formed from recombinant Norovirus VP1 proteins, and methods of their use and production are disclosed. In several embodiments, the Recombinant Norovirus VLPs can be used to generate an immune response to Norovirus VP1 protein in a subject. In additional embodiments, an effective amount of the recombinant Norovirus VLPs can be administered to a subject in a method of inhibiting a Norovirus infection.

公开(公告)号：US20170369558A1

公开(公告)日：2017-12-28

申请号：US15661867

申请日：2017-07-27

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv ,  University of Washington

发明人： John Mascola ,  Richard Wyatt ,  Xueling Wu ,  Yuxing Li ,  Carl-Magnus Hogerkorp ,  Mario Roederer ,  Zhi-yong Yang ,  Gary Nabel ,  Peter Kwong ,  Tongqing Zhou ,  Mark Connors ,  William Schief

IPC分类号： C07K16/10 ,  A61K39/42 ,  A61K45/06

CPC分类号： C07K16/1063 ,  A61K39/42 ,  A61K45/06 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2740/10011 ,  C12N2740/16011 ,  C12N2740/16111

摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.

公开(公告)号：US20160009789A1

公开(公告)日：2016-01-14

申请号：US14864705

申请日：2015-09-24

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv ,  University of Washington

发明人： John Mascola ,  Richard Wyatt ,  Xueling Wu ,  Yuxing Li ,  Carl-Magnus Hogerkorp ,  Mario Roederer ,  Zhi-yong Yang ,  Gary Nabel ,  Peter Kwong ,  Tongqing Zhou ,  Mark Connors ,  William Schief

IPC分类号： C07K16/10 ,  A61K45/06 ,  A61K39/42

CPC分类号： C07K16/1063 ,  A61K39/42 ,  A61K45/06 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2740/10011 ,  C12N2740/16011 ,  C12N2740/16111

摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.

摘要翻译： 公开了特异性结合HIV-1 gp120的CD4结合位点的单克隆中和抗体。 还公开了特异性结合HIV-1 gp41的单克隆中和抗体。 还公开了这些抗体的鉴定，以及这些抗体的用途。 还提供了用于增强使用表位支架探针的任何抗体的结合和中和活性的方法。