公开(公告)号：US10744193B2

公开(公告)日：2020-08-18

申请号：US15562862

申请日：2016-02-18

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Surender Khurana ,  Hana Golding

IPC分类号： A61K39/12 ,  C07K14/135 ,  A61P31/14 ,  C12N7/00 ,  G01N33/569 ,  A61K39/00

摘要： This invention provides immunogenic compositions comprising an immune stimulant and an respiratory syncytial virus (RSV) oligopeptide or an unglycosylated RSV polypeptide. The RSV oligopeptides are shown in SEQ ID NO: 3-33. The unglycosylated RSV polypeptide may consist essentially of the ectodomain of an RSV G protein, such as that shown in SEQ ID NO: 2 or the ectodomain of an RSV F protein such as the ectodomain of the F protein shown in SEQ ID NO: 39.

公开(公告)号：US11905313B2

公开(公告)日：2024-02-20

申请号：US16763497

申请日：2018-11-27

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Surender Khurana

IPC分类号： C07K14/005 ,  A61P31/14 ,  A61K39/155 ,  C07K7/06 ,  G01N33/569 ,  A61K39/00

CPC分类号： C07K14/005 ,  A61K39/155 ,  A61P31/14 ,  C07K7/06 ,  G01N33/56983 ,  A61K2039/5258 ,  A61K2039/53 ,  C07K2319/03 ,  C12N2760/18522 ,  C12N2760/18523 ,  G01N2333/135

摘要： Embodiments of a recombinant Respiratory Syncytial Virus (RSV) G ectodomain are provided. Also disclosed are nucleic acids encoding the RSV G ectodomain and methods of producing the RSV G ectodomain. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for inhibiting a RSV infection in a subject by administering an effective amount of the recombinant RSV G ectodomain to the subject to produce a protective immune response.

公开(公告)号：US11478542B2

公开(公告)日：2022-10-25

申请号：US16931291

申请日：2020-07-16

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Surender Khurana ,  Hana Golding

IPC分类号： A61K39/12 ,  C07K14/135 ,  A61P31/14 ,  C12N7/00 ,  G01N33/569 ,  A61K39/00

摘要： This invention provides immunogenic compositions comprising an immune stimulant and an respiratory syncytial virus (RSV) oligopeptide or an unglycosylated RSV polypeptide. The RSV oligopeptides are shown in SEQ ID NO: 3-33. The unglycosylated RSV polypeptide may consist essentially of the ectodomain of an RSV G protein, such as that shown in SEQ ID NO: 2 or the ectodomain of an RSV F protein such as the ectodomain of the F protein shown in SEQ ID NO: 39.

公开(公告)号：US11833199B2

公开(公告)日：2023-12-05

申请号：US17527968

申请日：2021-11-16

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Surender Khurana

IPC分类号： A61K39/12 ,  C07K14/005 ,  G01N33/569 ,  A61K39/00

CPC分类号： A61K39/12 ,  C07K14/005 ,  G01N33/56983 ,  A61K2039/6081 ,  C12N2760/14122 ,  C12N2760/14134 ,  G01N2469/20 ,  G01N2800/26

摘要： Isolated peptides comprising one or more antigenic sites of filovirus glycoprotein and methods of their use and production are disclosed. Nucleic acid molecules encoding the peptides are also provided. In several embodiments, the peptides can be used to induce an immune response to filovirus glycoprotein, such as Zaire ebolavirus glycoprotein, in a subject, for example, to treat or prevent infection of the subject with the virus.

公开(公告)号：US11202824B2

公开(公告)日：2021-12-21

申请号：US16346009

申请日：2017-10-31

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Surender Khurana

IPC分类号： A61K39/12 ,  C07K14/005 ,  G01N33/569 ,  A61K39/00

摘要： Isolated peptides comprising one or more antigenic sites of filovirus glycoprotein and methods of their use and production are disclosed. Nucleic acid molecules encoding the peptides are also provided. In several embodiments, the peptides can be used to induce an immune response to filovirus glycoprotein, such as Zaire ebolavirus glycoprotein, in a subject, for example, to treat or prevent infection of the subject with the virus.