公开(公告)号：US20220341922A1

公开(公告)日：2022-10-27

申请号：US17612378

申请日：2020-05-19

Applicant: The University of Tokyo

Inventor： Yosuke KITAGAWA ,  Shota TANAKA ,  Nobuhito SAITO ,  Yugo KURIKI ,  Mako KAMIYA ,  Yasuteru URANO

IPC: G01N33/533 ,  C07K5/06 ,  C09B11/24 ,  G01N33/574

Abstract: Provided is a novel fluorescent probe which can be used in a spray manner, has an outstandingly high sensitivity-specificity with instantaneousness, and enables detection of a brain tumor.
A fluorescent probe for detecting a brain tumor, including a compound of the following formula (I) or a salt thereof: wherein P1 represents an arginine residue, a histidine residue or a tyrosine residue, P2 represents a proline residue or a glycine residue, where P1 is linked to an adjacent N atom by forming an amide bond, and P2 is linked to P1 by forming an amide bond; R1 represents a hydrogen atom, or 1 to 4 identical or different substituents each independently selected from the group consisting of an optionally substituted alkyl group, a carboxyl group, an ester group, an alkoxy group, an amide group and an azide group; R2, R3, R4, R5, R6 and R7 each independently represent a hydrogen atom, a hydroxyl group, an optionally substituted alkyl group or a halogen atom; R8 and R9 each independently represent a hydrogen atom or an alkyl group;
X represents O, Si(Ra)(Rb), Ge(Ra)(Rb), Sn(Ra)(Rb), C(Ra) (Rb) or P(═O)(Ra); Ra and Rb each independently represent a hydrogen atom, an alkyl group or an aryl group; and Y represents a C1-C3 alkylene group.