公开(公告)号：US20240270911A1

公开(公告)日：2024-08-15

申请号：US18565142

申请日：2023-01-25

申请人： The University of Tokyo ,  GELLYCLE CO., LTD.

发明人： Takamasa SAKAI ,  Shohei ISHIKAWA ,  Hiroyuki KAMATA ,  Kosuke MASUI

IPC分类号： C08J3/075 ,  C08J3/24

CPC分类号： C08J3/075 ,  C08J3/246 ,  C08J2371/02

摘要： An object of the present invention is to provide a method for producing a hydrogel material having a μm-scale porous structure in a simple manner.
Provided is a method for producing a hydrogel having a porous structure, the production method including the following steps of a) to d): a) preparing a first solution in which a compound A is dissolved in an aqueous solvent containing an alkali metal salt at a concentration of 0 to 1000 mM; b) preparing a second solution in which a compound B chemically crosslinkable with the compound A is dissolved in an aqueous solvent containing an alkali metal salt at a concentration of 0 to 1000 mM; c) mixing the first solution and the second solution to obtain a gelling solution containing one or more alkali metal salts at a concentration of 300 mM to 1000 mM; and d) forming a chemical crosslinking by the compound A and the compound B in the gelling solution regardless of the presence or absence of an external stimulus to obtain a hydrogel having a porous structure, in which one of the compounds A and B is a linear, tri-branched, tetra-branched, or octa-branched polyethylene glycol (PEG) having a total of two or more nucleophilic functional groups or electrophilic functional groups in a side chain or at a terminal.