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公开(公告)号：US20230293778A1
公开(公告)日：2023-09-21
申请号：US17794295
申请日：2021-01-25
发明人： Takamasa SAKAI , Hironori HOJO , Shoichiro TANI , Kosuke MASUI , Shinichi NARITA
CPC分类号： A61L27/56 , A61L27/26 , A61L27/52 , A61L2430/02
摘要： An object of the present invention is to provide a novel use in which a polymer gel material having a µm-scale porous structure can be suitably used.
A gel material for regenerative medicine comprising a polymer gel in which hydrophilic polymer units are crosslinked with each other, wherein the polymer gel contains water as a solvent and has a three-dimensional network structure having two regions: a first region in which the polymer units are densely present and a second region in which the polymer units are sparsely present, and a mesh size composed of the first region is the range of 1 to 500 µm.-
2.发明公开公开(公告)号：US20240279403A1
公开(公告)日：2024-08-22
申请号：US18565147
申请日：2023-04-28
IPC分类号： C08G81/00 , C08G65/337
CPC分类号： C08G81/00 , C08G65/337
摘要： An object is to provide a novel artificial slime-like polymer material having stability against an external solvent without changing the chemical composition of a main chain skeleton, a solvent, and the like constituting the polymer material and without impairing the viscosity and elasticity of the slime-like material.
It has been found that by controlling the number of branches, terminal connectivity, and concentration of polymer units constituting the polymer material, it is possible to provide a slime-like polymer material that induces liquid-liquid phase separation and thereby control solubility in external solvents.-
公开(公告)号：US20240270911A1
公开(公告)日：2024-08-15
申请号：US18565142
申请日：2023-01-25
发明人： Takamasa SAKAI , Shohei ISHIKAWA , Hiroyuki KAMATA , Kosuke MASUI
CPC分类号： C08J3/075 , C08J3/246 , C08J2371/02
摘要： An object of the present invention is to provide a method for producing a hydrogel material having a μm-scale porous structure in a simple manner.
Provided is a method for producing a hydrogel having a porous structure, the production method including the following steps of a) to d): a) preparing a first solution in which a compound A is dissolved in an aqueous solvent containing an alkali metal salt at a concentration of 0 to 1000 mM; b) preparing a second solution in which a compound B chemically crosslinkable with the compound A is dissolved in an aqueous solvent containing an alkali metal salt at a concentration of 0 to 1000 mM; c) mixing the first solution and the second solution to obtain a gelling solution containing one or more alkali metal salts at a concentration of 300 mM to 1000 mM; and d) forming a chemical crosslinking by the compound A and the compound B in the gelling solution regardless of the presence or absence of an external stimulus to obtain a hydrogel having a porous structure, in which one of the compounds A and B is a linear, tri-branched, tetra-branched, or octa-branched polyethylene glycol (PEG) having a total of two or more nucleophilic functional groups or electrophilic functional groups in a side chain or at a terminal.-
公开(公告)号：US20230330304A1
公开(公告)日：2023-10-19
申请号：US18005919
申请日：2021-07-13
发明人： Takamasa SAKAI , Taku SAITO , Yasuhide IWANAGA , Sakae TANAKA , Kosuke MASUI , Shinichi NARITA
CPC分类号： A61L27/52 , A61L27/26 , A61L2430/10
摘要： To provide a method for suppressing the entry of scar tissue in the treatment of a tendon or ligament, promoting healing by intratendinous cells, and efficiently restoring the original function of the tendon.
A gel material including a polymer gel for suppressing expression of type III collagen in the treatment of an injured or ruptured tendon or ligament, in which
the polymer gel is a hydrogel having a three-dimensional network structure formed by crosslinking of hydrophilic polymers, and has a polymer content of from 1 to 5% by weight and an elastic modulus of from 100 to 10000 Pa.-
公开(公告)号：US20240294746A1
公开(公告)日：2024-09-05
申请号：US18565153
申请日：2023-04-28
IPC分类号： C08L51/08 , C08F8/42 , C08F283/06
CPC分类号： C08L51/08 , C08F8/42 , C08F283/06 , C08L2201/54 , C08L2205/025 , C08L2205/04
摘要： [Object]
An object of the present invention is to provide a novel artificial slime-like polymer material capable of controlling flow characteristics without changing a chemical composition such as a main chain skeleton or a solvent constituting the polymer material.
[Solution]
It is found that a slime-like polymer material in which liquid-liquid phase separation is induced can be provided and fluidity of the polymer material can be controlled by adding a polymer that does not react with a polymer unit serving as a basic skeleton constituting the polymer material in addition to the polymer unit.-
公开(公告)号：US20230218797A1
公开(公告)日：2023-07-13
申请号：US17922830
申请日：2021-05-06
发明人： Takamasa SAKAI , Kosuke MASUI , Shinichi NARITA , Hiroyuki KAMATA
CPC分类号： A61L24/0031 , A61L24/043
摘要： An object of the present invention is to provide a hemostatic method, a vascular occlusion method, a tissue covering method, and a body fluid coagulation method that are safe and efficient using a polymer material that is a non-biologically derived synthetic product.
A solution (pre-gel solution) is prepared that contains, under a specific concentration condition, a hydrophilic polymer capable of forming a hydrogel by intermolecular crosslinking and has a specific pH condition and specific ionic strength, and the solution is gelled in situ in an environment, such as a bleeding site or the interior of a blood vessel, where blood is present.
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