公开(公告)号：US20140302520A1

公开(公告)日：2014-10-09

申请号：US14352560

申请日：2012-10-17

申请人： The Washington University

发明人： Randall J. Bateman ,  Timothy M. Miller ,  Ling Munsell

IPC分类号： G01N33/577

CPC分类号： G01N33/577 ,  C12Q1/26 ,  G01N33/5058 ,  G01N33/5088 ,  G01N33/6896 ,  G01N2333/90283 ,  G01N2560/00 ,  G01N2800/28

摘要： The disclosure relates to methods for the diagnosis and treatment of neurological and neurodegenerative diseases, disorders, and associated processes. Specifically, the disclosure relates to a method for measuring the metabolism of central nervous system derived biomolecules in a subject in vivo. Further disclosed are methods for measuring the in vivo metabolism (e.g. the rate of synthesis, the rate of clearance) of neurally derived biomolecules, such as superoxide dismutase 1 (SOD1).

摘要翻译： 本公开涉及用于诊断和治疗神经和神经退行性疾病，病症和相关过程的方法。 具体地，本公开涉及一种用于测量受试者体内衍生的中枢神经系统生物分子的代谢的方法。 还公开了用于测量神经衍生的生物分子例如超氧化物歧化酶1（SOD1）的体内代谢（例如合成速率，清除速率）的方法。