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公开(公告)号：US11981724B2
公开(公告)日：2024-05-14
申请号：US17560727
申请日：2021-12-23
发明人： David Weiner , Trevor R F Smith , Kar Muthumani
摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to a Middle East Respiratory Syncytial Coronavirus (MERS-CoV) viral antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an MERS-CoV virus infection in a subject using said composition and method of generation.
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公开(公告)号：US20230338515A1
公开(公告)日：2023-10-26
申请号：US18311056
申请日：2023-05-02
发明人： Jian Yan , Kate Broderick , David Weiner , Kar Muthumani , Ami Patel
IPC分类号： A61K39/215 , C12N15/86
CPC分类号： A61K39/215 , C12N15/86 , A61K2039/545
摘要： Disclosed herein are nucleic acid molecules encoding a SARS-CoV-2 spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection in a subject.
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公开(公告)号：US11230592B2
公开(公告)日：2022-01-25
申请号：US16651435
申请日：2018-09-27
发明人： David Weiner , Trevor R F Smith , Kar Muthumani
摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to a Middle East Respiratory Syncytial Coronavirus (MERS-CoV) viral antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an MERS-CoV virus infection in a subject using said composition and method of generation.
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公开(公告)号：US20230203133A1
公开(公告)日：2023-06-29
申请号：US17997963
申请日：2021-05-06
发明人： Kar Muthumani , David Weiner
CPC分类号： C07K16/082 , A61P31/20 , C12N15/63 , A61K45/06
摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to a Hepatitis B viral antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating a Hepatitis B virus infection in a subject using said composition and method of generation.
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公开(公告)号：US20220370598A1
公开(公告)日：2022-11-24
申请号：US17662141
申请日：2022-05-05
发明人： Jian Yan , Kate Broderick , David Weiner , Kar Muthumani , Ami Patel
IPC分类号： A61K39/215 , A61P31/14 , A61K9/00
摘要： Provided herein are methods of inducing an immune response against Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) in a subject in need thereof by administering an immunogenic composition to the subject, wherein the subject exhibits: an increase in antigen-specific cellular immune response as measured by Interferon-gamma (IFN-γ) Enzyme-linked Immunospot (ELISpot) assay relative to baseline; and/or an increase in neutralizing antibody response as measured by a pseudovirus neutralizing assay relative to baseline.
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公开(公告)号：US20220098324A1
公开(公告)日：2022-03-31
申请号：US17427434
申请日：2020-01-30
摘要： Disclosed herein are compositions comprising a recombinant nucleic acid sequence encoding a bispecific immune cell engaging antibody (DICE), a recombinant nucleic acid sequence encoding a bispecific T cell engaging (DBiTE) antibody, a fragment thereof, a variant thereof, or a combination thereof.
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公开(公告)号：US20220054620A1
公开(公告)日：2022-02-24
申请号：US17416199
申请日：2019-12-20
发明人： Kar Muthumani , David Weiner , Hyeree Choi , Sagar B. Kudchodkar
摘要： An aspect of the present invention is related to nucleic acid constructs capable of expressing at least one Powassan virus (POWV) antigen that elicits an immune response in a mammal against POWV virus, and methods of use thereof.
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公开(公告)号：US20240189405A1
公开(公告)日：2024-06-13
申请号：US18413721
申请日：2024-01-16
申请人： The Trustees of the University of Pennsylvania , The Wistar Institute of Anatomy and Biology , Inovio Pharmaceuticals, Inc.
IPC分类号： A61K39/00 , A61K31/7088 , A61K39/395 , A61P35/00 , C07K16/28 , C12N15/85
CPC分类号： A61K39/001129 , A61K31/7088 , A61K39/395 , A61P35/00 , C07K16/2803 , C07K16/2818 , C07K16/2878 , C12N15/85 , A61K2039/505 , A61K2039/53
摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody or fragment thereof that targets an immune checkpoint molecule. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
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9.发明公开公开(公告)号：US20240101626A1
公开(公告)日：2024-03-28
申请号：US18546306
申请日：2022-02-11
发明人： Kar Muthumani , David Weiner
CPC分类号： C07K14/4748 , A61K39/001193 , A61P37/04 , C12N9/16 , C12Y301/03002 , A61K39/00 , A61K2039/53
摘要： The present invention provides consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PAP, PARM, PCTA, PSCA, PSP94, and STEAP antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PAP, PARM, PCTA, PSCA, PSP94, and STEAP antigens, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.
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公开(公告)号：US11660335B2
公开(公告)日：2023-05-30
申请号：US17185458
申请日：2021-02-25
发明人： Jian Yan , Kate Broderick , David Weiner , Kar Muthumani , Ami Patel
IPC分类号： A61K39/215 , C12N15/86 , A61K39/00
CPC分类号： A61K39/215 , C12N15/86 , A61K2039/545 , C12N2770/20034 , C12N2770/20044
摘要： Disclosed herein are nucleic acid molecules encoding a SARS-CoV-2 spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection in a subject.
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