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公开(公告)号：US20230338515A1
公开(公告)日：2023-10-26
申请号：US18311056
申请日：2023-05-02
发明人： Jian Yan , Kate Broderick , David Weiner , Kar Muthumani , Ami Patel
IPC分类号： A61K39/215 , C12N15/86
CPC分类号： A61K39/215 , C12N15/86 , A61K2039/545
摘要： Disclosed herein are nucleic acid molecules encoding a SARS-CoV-2 spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection in a subject.
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公开(公告)号：US20210388033A1
公开(公告)日：2021-12-16
申请号：US17404143
申请日：2021-08-17
申请人： The Trustees of the University of Pennsylvania , THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY , Inovio Pharmaceuticals, Inc.
发明人： David B. Weiner , Ami Patel , Jian Yan
摘要： Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Ebolavirus glycoproteinimmunogens are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response against Ebolavirus are disclosed. Method of preventing Ebolavirus and methods of treating individuals infected with Ebolavirus are disclosed. Consensus Ebolavirus proteins are disclosed.
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3.发明公开公开(公告)号：US20240115680A1
公开(公告)日：2024-04-11
申请号：US18541798
申请日：2023-12-15
申请人： The Trustees of the University of Pennsylvania , Inovio Pharmaceuticals, Inc. , The Wistar Institute of Anatomy and Biology
CPC分类号： A61K39/001102 , A61K38/1796 , A61K39/0011 , A61P35/00 , C07K14/723 , A61K2039/5256 , A61K2039/53 , A61K2039/572 , A61K2039/892
摘要： Provided herein is an immunogenic composition comprising a synthetic consensus antigen to Follicle Stimulating Hormone Receptor (FSHR) protein which is abundant in many ovarian cancer sub-types. Also disclosed herein is a method of treating a tumor associated pathology in a subject in need thereof, by administering the immunogenic composition to the subject.
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公开(公告)号：US11865166B2
公开(公告)日：2024-01-09
申请号：US16328404
申请日：2017-08-29
申请人： The Trustees of the University of Pennsylvania , Inovio Pharmaceuticals, Inc. , THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
CPC分类号： A61K39/001102 , A61K38/1796 , A61K39/0011 , A61P35/00 , C07K14/723 , A61K2039/5256 , A61K2039/53 , A61K2039/572 , A61K2039/892
摘要： Provided herein is an immunogenic composition comprising a synthetic consensus antigen to Follicle Stimulating Hormone Receptor (FSHR) protein which is abundant in many ovarian cancer sub-types. Also disclosed herein is a method of treating a tumor associated pathology in a subject in need thereof, by administering the immunogenic composition to the subject.
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公开(公告)号：US20220370598A1
公开(公告)日：2022-11-24
申请号：US17662141
申请日：2022-05-05
发明人： Jian Yan , Kate Broderick , David Weiner , Kar Muthumani , Ami Patel
IPC分类号： A61K39/215 , A61P31/14 , A61K9/00
摘要： Provided herein are methods of inducing an immune response against Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) in a subject in need thereof by administering an immunogenic composition to the subject, wherein the subject exhibits: an increase in antigen-specific cellular immune response as measured by Interferon-gamma (IFN-γ) Enzyme-linked Immunospot (ELISpot) assay relative to baseline; and/or an increase in neutralizing antibody response as measured by a pseudovirus neutralizing assay relative to baseline.
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6.发明公开公开(公告)号：US20240226291A9
公开(公告)日：2024-07-11
申请号：US18477785
申请日：2023-09-29
申请人： The Trustees of the University of Pennsylvania , Inovio Pharmaceuticals, Inc. , The Wistar Institute of Anatomy and Biology
发明人： David Weiner , Karuppiah Muthumani , Jian Yan
CPC分类号： A61K39/42 , A61K39/12 , A61P31/14 , C07K14/18 , C07K16/10 , C07K16/1081 , A61K2039/53
摘要： Disclosed herein is a composition comprising a recombinant nucleic acid sequence that encodes an antibody to a Zika viral antigen, and functional fragments thereof. The invention also relates to a composition comprising the combination of a first composition that elicits an immune response in a mammal against zika virus and a second composition comprising a recombinant nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof. In some instances, the nucleic acid molecule comprises a nucleotide sequence encoding an anti-ZIKV-Envelope (anti-ZIKV E) Protein antibody.
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公开(公告)号：US20210268102A1
公开(公告)日：2021-09-02
申请号：US17185458
申请日：2021-02-25
发明人： Jian Yan , Kate Broderick , David Weiner , Kar Muthumani , Ami Patel
IPC分类号： A61K39/215 , C12N15/86
摘要： Disclosed herein are nucleic acid molecules encoding a SARS-CoV-2 spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection in a subject.
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公开(公告)号：US11091518B2
公开(公告)日：2021-08-17
申请号：US16098912
申请日：2017-05-05
申请人： The Trustees of the University of Pennsylvania , THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY , Inovio Pharmaceuticals, Inc.
发明人： David B. Weiner , Ami Patel , Jian Yan
IPC分类号： C07K14/005 , A61K31/12 , A61K39/12 , A61K38/00 , A61P31/12 , A61K9/00 , A61K39/39 , C07K14/54 , A61K39/00
摘要： Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Ebolavirus glycoproteinimmunogens are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response against Ebolavirus are disclosed. Method of preventing Ebolavirus and methods of treating individuals infected with Ebolavirus are disclosed. Consensus Ebolavirus proteins are disclosed.
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公开(公告)号：US20190153076A1
公开(公告)日：2019-05-23
申请号：US16098908
申请日：2017-05-05
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY , INOVIO PHARMACEUTICALS, INC.
发明人： David Weiner , Ami Patel , Jian Yan
IPC分类号： C07K16/12 , A61K39/40 , A61K31/407 , C07K16/46 , A61P31/04
摘要： Disclosed herein are mono and bispecific DNA antibodies (DMAbs) targeting Pseudomonas aeruginosa. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the DMAbs to the subject. The disclosure also provides a method of preventing and/or treating Pseudomonas aeruginosa infection in a subject using said composition and method of generation.
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10.发明公开公开(公告)号：US20240131154A1
公开(公告)日：2024-04-25
申请号：US18477785
申请日：2023-09-28
申请人： The Trustees of the University of Pennsylvania , Inovio Pharmaceuticals, Inc. , The Wistar Institute of Anatomy and Biology
发明人： David Weiner , Karuppiah Muthumani , Jian Yan
CPC分类号： A61K39/42 , A61K39/12 , A61P31/14 , C07K14/18 , C07K16/10 , C07K16/1081 , A61K2039/53
摘要： Disclosed herein is a composition comprising a recombinant nucleic acid sequence that encodes an antibody to a Zika viral antigen, and functional fragments thereof. The invention also relates to a composition comprising the combination of a first composition that elicits an immune response in a mammal against zika virus and a second composition comprising a recombinant nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof. In some instances, the nucleic acid molecule comprises a nucleotide sequence encoding an anti-ZIKV-Envelope (anti-ZIKV E) Protein antibody.
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