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1.发明公开公开(公告)号：US20240101626A1
公开(公告)日：2024-03-28
申请号：US18546306
申请日：2022-02-11
发明人： Kar Muthumani , David Weiner
CPC分类号： C07K14/4748 , A61K39/001193 , A61P37/04 , C12N9/16 , C12Y301/03002 , A61K39/00 , A61K2039/53
摘要： The present invention provides consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PAP, PARM, PCTA, PSCA, PSP94, and STEAP antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PAP, PARM, PCTA, PSCA, PSP94, and STEAP antigens, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.
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公开(公告)号：US20230212267A1
公开(公告)日：2023-07-06
申请号：US18000886
申请日：2021-06-09
发明人： David Weiner , Elizabeth Parzych , Kar Muthumani
CPC分类号： C07K16/10 , C12N15/63 , A61P31/14 , C07K2317/565
摘要： Disclosed herein are antibodies to SARS-CoV-2 antigens and recombinant nucleic acid sequences that encode the SARS-CoV-2 antibodies. The disclosure also provides a method of preventing and/or treating a SARS-CoV-2 infection or disease or disorder associated with SARS-CoV-2 infection (e.g., COVID-19) in a subject using said compositions and methods.
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公开(公告)号：US20240270805A1
公开(公告)日：2024-08-15
申请号：US18588643
申请日：2024-02-27
发明人： David Weiner , Elizabeth Duperret
CPC分类号： C07K14/4748 , A61K39/001186 , A61K39/39 , A61K45/06 , A61P35/00 , A61K2039/53 , A61K2039/55527 , A61K2039/55533 , A61K2039/572 , A61K2039/86 , A61K2039/876
摘要： Disclosed herein are compositions and methods for treating and/or preventing cancer in mammals, and in particular, vaccines that treat and provide protection against tumor growth.
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公开(公告)号：US11981724B2
公开(公告)日：2024-05-14
申请号：US17560727
申请日：2021-12-23
发明人： David Weiner , Trevor R F Smith , Kar Muthumani
摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to a Middle East Respiratory Syncytial Coronavirus (MERS-CoV) viral antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an MERS-CoV virus infection in a subject using said composition and method of generation.
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5.发明公开公开(公告)号：US20240009300A1
公开(公告)日：2024-01-11
申请号：US18251620
申请日：2021-11-03
发明人： Daniel Kulp , Ziyang Xu , David Weiner
IPC分类号： A61K39/215 , A61P31/14 , C07K14/165
CPC分类号： A61K39/215 , A61P31/14 , C07K14/165
摘要： Disclosed herein are nanoparticles comprising one or more SARS coronavirus 2 (SARS-CoV-2) Spike receptor binding domain (RBD) antigen and nucleic acid molecules encoding the same. Also disclosed herein is a method of treating a SARS-COV-2 infection or treating or preventing a disease or disorder associated therewith in a subject in need thereof, by administering the nanoparticles, or encoding nucleic acid molecules, to the subject.
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公开(公告)号：US20230338515A1
公开(公告)日：2023-10-26
申请号：US18311056
申请日：2023-05-02
发明人： Jian Yan , Kate Broderick , David Weiner , Kar Muthumani , Ami Patel
IPC分类号： A61K39/215 , C12N15/86
CPC分类号： A61K39/215 , C12N15/86 , A61K2039/545
摘要： Disclosed herein are nucleic acid molecules encoding a SARS-CoV-2 spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection in a subject.
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公开(公告)号：US11230592B2
公开(公告)日：2022-01-25
申请号：US16651435
申请日：2018-09-27
发明人： David Weiner , Trevor R F Smith , Kar Muthumani
摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to a Middle East Respiratory Syncytial Coronavirus (MERS-CoV) viral antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an MERS-CoV virus infection in a subject using said composition and method of generation.
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公开(公告)号：US20210308243A1
公开(公告)日：2021-10-07
申请号：US17264545
申请日：2019-08-01
发明人： David Weiner
摘要： Provided herein is an immunogenic composition comprising a synthetic consensus antigen to chondroitin sulfate proteoglycan 4 (CSPG4) protein which is abundant in many cancers. Also disclosed herein is a method of treating a tumor associated pathology in a subject in need thereof, by administering the immunogenic composition to the subject.
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9.发明申请公开(公告)号：US20210038711A1
公开(公告)日：2021-02-11
申请号：US16970084
申请日：2019-02-15
IPC分类号： A61K39/245 , A61P31/22 , C12N15/79 , C07K14/05
摘要： Nucleic acid molecules and compositions comprising one or more nucleotide sequences that encode a consensus Epstein-Barr virus (EBV) antigen. Immunomodulatory methods and methods of inducing an immune response against EBV are disclosed. Method of treating infection by EBV and methods of treating or preventing a disease or disorder associated with EBV are disclosed. Modified consensus EBV antigens are disclosed.
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10.发明公开公开(公告)号：US20240261388A1
公开(公告)日：2024-08-08
申请号：US18407958
申请日：2024-01-09
发明人： David Weiner , Megan Wise
IPC分类号： A61K39/21 , A61K39/00 , A61K39/02 , C07K14/005
CPC分类号： A61K39/21 , A61K39/02 , C07K14/005 , A61K2039/53 , A61K2039/54 , A61K2039/545 , C12N2740/16134 , C12N2740/16171
摘要： The present invention relates to compositions comprising two or more DNA plasmids encoding consensus and transmitted founder HIV envelope glycoproteins which expressed and induce a potent immune response.
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