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公开(公告)号:US09505800B2
公开(公告)日:2016-11-29
申请号:US12513454
申请日:2007-11-02
CPC分类号: C07J63/008 , A61K31/57 , A61K31/58 , A61K45/06 , C07J53/00
摘要: The present invention concerns novel pharmaceutically active triterpene derivatives, pharmaceutical compositions containing the same, their use as medicaments, and the use of the compounds for the manufacture of specific medicaments. The present invention also concerns a method of treatment involving administration of the compounds. Specifically, the compounds are derivatives of betulinic acid having substitutions at one or more of the C-3, C2-8 and C-19 positions as further described herein. The novel compounds are useful as antiretroviral agents. In particular, the novel compounds are useful for the treatment of Human Immunodeficiency Virus (HIV).
摘要翻译: 本发明涉及新颖的药学活性三萜衍生物,含有它们的药物组合物,它们作为药物的用途,以及该化合物在制备特定药物中的用途。 本发明还涉及涉及给药化合物的治疗方法。 具体地,化合物是在本文进一步描述的C-3,C 2-8和C-19位置的一个或多个处具有取代的桦木酸的衍生物。 新型化合物可用作抗逆转录病毒药物。 特别地,新化合物可用于治疗人类免疫缺陷病毒(HIV)。
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公开(公告)号:US20120046291A1
公开(公告)日:2012-02-23
申请号:US12513454
申请日:2007-11-02
IPC分类号: A61K31/215 , C07C69/34 , C07D295/096 , A61P31/12 , A61K31/495 , A61K31/40 , C07C245/20 , A61P31/18 , C07C69/732 , A61K31/5375
CPC分类号: C07J63/008 , A61K31/57 , A61K31/58 , A61K45/06 , C07J53/00
摘要: The present invention concerns novel pharmaceutically active triterpene derivatives, pharmaceutical compositions containing the same, their use as medicaments, and the use of the compounds for the manufacture of specific medicaments. The present invention also concerns a method of treatment involving administration of the compounds. Specifically, the compounds are derivatives of betulinic acid having substitutions at one or more of the C-3, C2-8 and C-19 positions as further described herein. The novel compounds are useful as antiretroviral agents. In particular, the novel compounds are useful for the treatment of Human Immunodeficiency Virus (HIV).
摘要翻译: 本发明涉及新颖的药学活性三萜衍生物,含有它们的药物组合物,它们作为药物的用途,以及该化合物在制备特定药物中的用途。 本发明还涉及涉及给药化合物的治疗方法。 具体地,化合物是在本文进一步描述的C-3,C 2-8和C-19位置的一个或多个处具有取代的桦木酸的衍生物。 新型化合物可用作抗逆转录病毒药物。 特别地,新化合物可用于治疗人类免疫缺陷病毒(HIV)。
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公开(公告)号:US20050181149A1
公开(公告)日:2005-08-18
申请号:US11055296
申请日:2005-02-10
申请人: Edward Glenn
发明人: Edward Glenn
CPC分类号: A01G5/04
摘要: A single-use wreath foundation for use in constructing a single use wreath is constructed of a primary frame member having a lower section, a secondary frame member attached to the lower section, a foam covering over at least a part of the primary frame member, and a plant material holder supported by the secondary frame member. The secondary frame member may be in the shape of a wire basket, or the secondary frame member may be in the shape of a loop that is substantially perpendicular to the primary frame member, with the primary frame member including a downwardly extending lower section, with the holder being supported by the horizontal loop and lower section. The holder may be a container or a block of foam. The secondary frame member may also be at least partially covered with a foam covering.
摘要翻译: 用于构造单用花环的一次性花圈基座由具有下部的主框架构件,附接到下部的副框架构件,覆盖在主框架构件的至少一部分上的泡沫构成, 以及由所述辅助框架构件支撑的植物材料保持器。 辅助框架构件可以是线篮的形状,或者辅助框架构件可以是基本上垂直于主框架构件的环的形状,其中主框架构件包括向下延伸的下部,其具有 保持器由水平环和下部支撑。 支架可以是容器或泡沫块。 辅助框架构件也可以至少部分地被泡沫覆盖物覆盖。
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