-
公开(公告)号：US09505800B2
公开(公告)日：2016-11-29
申请号：US12513454
申请日：2007-11-02
CPC分类号： C07J63/008 , A61K31/57 , A61K31/58 , A61K45/06 , C07J53/00
摘要： The present invention concerns novel pharmaceutically active triterpene derivatives, pharmaceutical compositions containing the same, their use as medicaments, and the use of the compounds for the manufacture of specific medicaments. The present invention also concerns a method of treatment involving administration of the compounds. Specifically, the compounds are derivatives of betulinic acid having substitutions at one or more of the C-3, C2-8 and C-19 positions as further described herein. The novel compounds are useful as antiretroviral agents. In particular, the novel compounds are useful for the treatment of Human Immunodeficiency Virus (HIV).
摘要翻译： 本发明涉及新颖的药学活性三萜衍生物，含有它们的药物组合物，它们作为药物的用途，以及该化合物在制备特定药物中的用途。 本发明还涉及涉及给药化合物的治疗方法。 具体地，化合物是在本文进一步描述的C-3，C 2-8和C-19位置的一个或多个处具有取代的桦木酸的衍生物。 新型化合物可用作抗逆转录病毒药物。 特别地，新化合物可用于治疗人类免疫缺陷病毒（HIV）。
-
公开(公告)号：US20120046291A1
公开(公告)日：2012-02-23
申请号：US12513454
申请日：2007-11-02
IPC分类号： A61K31/215 , C07C69/34 , C07D295/096 , A61P31/12 , A61K31/495 , A61K31/40 , C07C245/20 , A61P31/18 , C07C69/732 , A61K31/5375
CPC分类号： C07J63/008 , A61K31/57 , A61K31/58 , A61K45/06 , C07J53/00
摘要： The present invention concerns novel pharmaceutically active triterpene derivatives, pharmaceutical compositions containing the same, their use as medicaments, and the use of the compounds for the manufacture of specific medicaments. The present invention also concerns a method of treatment involving administration of the compounds. Specifically, the compounds are derivatives of betulinic acid having substitutions at one or more of the C-3, C2-8 and C-19 positions as further described herein. The novel compounds are useful as antiretroviral agents. In particular, the novel compounds are useful for the treatment of Human Immunodeficiency Virus (HIV).
摘要翻译： 本发明涉及新颖的药学活性三萜衍生物，含有它们的药物组合物，它们作为药物的用途，以及该化合物在制备特定药物中的用途。 本发明还涉及涉及给药化合物的治疗方法。 具体地，化合物是在本文进一步描述的C-3，C 2-8和C-19位置的一个或多个处具有取代的桦木酸的衍生物。 新型化合物可用作抗逆转录病毒药物。 特别地，新化合物可用于治疗人类免疫缺陷病毒（HIV）。
-
![Alpha-substituted Arylmethyl Piperazine Pyrazolo [1,5-alpha]Pyrimidine Amide Derivatives](/abs-image/US/2009/08/27/US20090215778A1/abs.jpg.150x150.jpg)
3.发明申请Alpha-substituted Arylmethyl Piperazine Pyrazolo [1,5-alpha]Pyrimidine Amide Derivatives 审中-公开α-取代的芳基甲基哌嗪吡唑并[1,5-a]嘧啶酰胺衍生物公开(公告)号：US20090215778A1
公开(公告)日：2009-08-27
申请号：US12149178
申请日：2008-04-28
申请人： Theodore J. Nitz , Karl Salzwedel , Catherine Finnegan , Shirley Brunton , Stuart Flanagan , Christian Montalbetti , Thomas Stephen Coulter
发明人： Theodore J. Nitz , Karl Salzwedel , Catherine Finnegan , Shirley Brunton , Stuart Flanagan , Christian Montalbetti , Thomas Stephen Coulter
IPC分类号： C07D487/04 , A61K31/496 , A61K31/519 , A61K31/5377 , A61P31/18
CPC分类号： C07D487/04
摘要： Derivatives of pyrazolopyrimidine compounds represented by Formula I are disclosed: These pyrazolopyrimidine derivatives and pharmaceutical compositions comprising these derivatives are useful in the treatment of HIV mediated diseases and conditions.
摘要翻译： 公开了由式I表示的吡唑并嘧啶化合物的衍生物：这些吡唑并嘧啶衍生物和包含这些衍生物的药物组合物可用于治疗HIV介导的疾病和病症。
-
公开(公告)号：US20060205697A1
公开(公告)日：2006-09-14
申请号：US11272019
申请日：2005-11-14
申请人： Gary Robinson , Carl Wild , Mark Ashton , Russell Thomas , Christian Montalbetti , Thomas Coulter , Filippo Magaraci , Robert Townsend , Theodore Nitz
发明人： Gary Robinson , Carl Wild , Mark Ashton , Russell Thomas , Christian Montalbetti , Thomas Coulter , Filippo Magaraci , Robert Townsend , Theodore Nitz
摘要： The present invention relates to novel synthetic derivatives of betulin and the use of such derivatives as pharmaceuticals. The present invention is directed to novel compounds of Formula I: or a pharmaceutically acceptable salt or prodrug thereof.
摘要翻译： 本发明涉及新颖的桦木素合成衍生物和药物衍生物的用途。 本发明涉及新的式I化合物：或其药学上可接受的盐或前药。
-
5.发明申请Diphenyl Ox-Indol-2-One Compounds and Their Use in the Treatment of Cancer 审中-公开二苯基吲哚-2-酮化合物及其在治疗癌症中的应用公开(公告)号：US20070299102A1
公开(公告)日：2007-12-27
申请号：US10599121
申请日：2005-04-08
申请人： Jakob Felding , Hans Pedersen , Christian Krog-Jensen , Morten Praestegaard , Steven Butcher , Viggo Linde , Thomas Coulter , Christian Montalbetti , Mohammed Uddin , Serge Reignier
发明人： Jakob Felding , Hans Pedersen , Christian Krog-Jensen , Morten Praestegaard , Steven Butcher , Viggo Linde , Thomas Coulter , Christian Montalbetti , Mohammed Uddin , Serge Reignier
IPC分类号： A61K31/40 , A61K31/44 , A61P43/00 , C07D209/36 , C07D221/02
CPC分类号： A61K31/404 , A61K31/407 , A61K31/4188 , A61K31/429 , A61K31/437 , A61K31/4439 , A61K31/4745 , A61K31/496 , A61K31/5025 , A61K31/5377
摘要： The present invention relates to substituted 3,3-diphenyl-1,3-dihydro-indol-2-one compounds, and the use of such compounds for the preparation of a medicament for the treatment of cancer in a mammal. It is postulated that treatment of cancers is achieved in which inhibition of protein synthesis and/or inhibition of activation of the mTOR pathway is an effective method for reducing cell growth. Examples of such cancers are breast cancer, renal cancer, multiple myeloma, leukemia, glia blastoma, rhabdomyosarcoma, prostate, soft tissue sarcoma, colorectal sarcoma, gastric carcinoma, head and neck squamous cell carcinoma, uterine, cervical, melanoma, lymphoma, and pancreatic cancer. A particular subclass of compounds are represented by the formula (II) wherein at least one of X1 and X2 is a heteroatom substituent, e.g. 6-chloro-3,3-bis-(4-hydroxy-phenyl)-7-methyl-1,3-dihydro-indol-2-one.
摘要翻译： 本发明涉及取代的3,3-二苯基-1,3-二氢 - 吲哚-2-酮化合物，以及这些化合物在哺乳动物中制备用于治疗癌症的药物的用途。 假定癌症的治疗实现了其中抑制蛋白质合成和/或抑制mTOR途径的活化是减少细胞生长的有效方法。 这样的癌症的例子是乳腺癌，肾癌，多发性骨髓瘤，白血病，胶质母细胞瘤，横纹肌肉瘤，前列腺，软组织肉瘤，结肠直肠肉瘤，胃癌，头颈鳞状细胞癌，子宫颈，宫颈癌，黑素瘤，淋巴瘤和胰腺癌 癌症。 化合物的特定亚类由式（II）表示，其中X 1和X 2中的至少一个是杂原子取代基，例如杂原子取代基。 6-氯-3,3-双 - （4-羟基 - 苯基）-7-甲基-1,3-二氢 - 吲哚-2-酮。
-
-
-
-
搜索结果
5 条记录 (耗时 0.031 秒)
